7-Chlorokynurenic acid

A chemical compound used in scientific research

7-Chlorokynurenic acid is a chemical compound that acts as an antagonist at the glycine site of the NMDA receptor. It is primarily used in scientific research to study the role of the NMDA receptor in various physiological and pathological processes.

Chemical structure and properties

7-Chlorokynurenic acid is a derivative of kynurenic acid, which is a metabolite of the amino acid tryptophan. The addition of a chlorine atom at the 7-position of the kynurenic acid molecule enhances its ability to block the glycine site of the NMDA receptor.

Mechanism of action

The NMDA receptor is a type of glutamate receptor that plays a key role in synaptic plasticity and memory. It requires the binding of both glutamate and glycine to become activated. 7-Chlorokynurenic acid competes with glycine for binding to the NMDA receptor, thereby inhibiting its activation. This makes it a useful tool for studying the involvement of NMDA receptors in various neurological processes.

Applications in research

7-Chlorokynurenic acid is used in research to investigate the role of NMDA receptors in conditions such as neurodegenerative diseases, schizophrenia, and chronic pain. By blocking the glycine site, researchers can study how changes in NMDA receptor activity affect neuronal function and behavior.

Safety and handling

As with many research chemicals, proper safety precautions should be taken when handling 7-Chlorokynurenic acid. It should be used in a controlled laboratory environment, and appropriate personal protective equipment should be worn.

Related pages

• NMDA receptor
• Kynurenic acid
• Glutamate receptor
• Synaptic plasticity

Gallery

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  Chemical structure of 7-Chlorokynurenic acid