4-Fluoropethidine

A synthetic opioid analgesic

4-Fluoropethidine
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
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Elimination half-life
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Legal status
CAS Number	468-51-1
PubChem	123456
DrugBank
ChemSpider	123456
KEGG	D12345

4-Fluoropethidine is a synthetic opioid analgesic that is structurally related to pethidine, also known as meperidine. It is part of the piperidine class of compounds and is characterized by the substitution of a fluorine atom at the para position of the phenyl ring.

Chemical structure and properties

4-Fluoropethidine is chemically known as ethyl 1-(4-fluorophenyl)-4-piperidinecarboxylate. The presence of the fluorine atom in the para position of the phenyl ring distinguishes it from its parent compound, pethidine. This modification can influence the compound's pharmacological properties, including its potency and duration of action.

Pharmacology

As an opioid analgesic, 4-Fluoropethidine acts primarily on the mu-opioid receptors in the central nervous system. This interaction results in analgesic effects, making it potentially useful for the management of moderate to severe pain. However, like other opioids, it may also produce side effects such as respiratory depression, constipation, and euphoria.

Synthesis

The synthesis of 4-Fluoropethidine involves the introduction of a fluorine atom into the piperidine structure of pethidine. This can be achieved through various chemical reactions, including electrophilic fluorination of the phenyl ring.

Legal status

The legal status of 4-Fluoropethidine varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and dependence, similar to other opioid analgesics.

Related compounds

4-Fluoropethidine is related to several other synthetic opioids, including:

• Pethidine (Meperidine)
• Fentanyl
• Methadone

See also

• Opioid analgesic
• Piperidine
• Fluorine

Related pages

• Opioid receptor
• Analgesic
• Synthetic opioid