Trestolone acetate

Synthetic anabolic-androgenic steroid

Trestolone acetate, also known as 7_-methyl-19-nortestosterone 17_-acetate (MENT), is a synthetic anabolic-androgenic steroid (AAS) and a derivative of nandrolone. It is primarily used in scientific research and has been investigated for potential applications in male contraception and hormone replacement therapy.

Chemical structure and properties

Trestolone acetate is a nandrolone derivative, characterized by the presence of a methyl group at the 7_ position. This modification enhances its androgenic and anabolic activity compared to nandrolone. The acetate ester attached to the 17_-hydroxyl group prolongs its duration of action by slowing its release into the bloodstream.

Pharmacology

Trestolone acetate acts as a potent agonist of the androgen receptor (AR), which mediates its anabolic and androgenic effects. It has been shown to have a high binding affinity for the AR, leading to significant increases in muscle mass and strength. Unlike testosterone, trestolone acetate does not undergo conversion to dihydrotestosterone (DHT), which may reduce the risk of certain androgenic side effects.

Potential applications

Male contraception

Trestolone acetate has been studied as a potential male contraceptive due to its ability to suppress spermatogenesis while maintaining libido and other androgen-dependent functions. Clinical trials have explored its efficacy in combination with other hormones, such as progestins, to achieve effective contraception.

Hormone replacement therapy

In hormone replacement therapy for men with hypogonadism, trestolone acetate may offer advantages over traditional testosterone therapy. Its potent anabolic effects and lack of conversion to DHT make it a promising candidate for maintaining muscle mass and bone density.

Side effects

As with other AAS, trestolone acetate can cause a range of side effects, including acne, gynecomastia, and cardiovascular issues. Long-term use may also lead to liver damage and alterations in lipid profiles.

Legal status

The legal status of trestolone acetate varies by country. In some regions, it is classified as a controlled substance, while in others, it is available for research purposes only.

Related pages

• Anabolic steroid
• Nandrolone
• Testosterone
• Male contraception

References

Chemical structure of trestolone acetate