Mazzotti reaction

Mazzotti reaction is a symptom complex seen in patients after undergoing treatment of Onchocerciasis, a parasitic disease also known as river blindness. The reaction is most often caused by the death of the microfilariae of the parasites, which in turn leads to severe itching, swollen skin, and other secondary skin conditions.

Causes

The Mazzotti reaction is primarily caused by the death of the microfilariae of Onchocerca volvulus, a parasitic worm that causes Onchocerciasis. The reaction is most commonly observed following the administration of the drug Ivermectin, which is used to treat the disease.

Symptoms

The symptoms of the Mazzotti reaction can vary in severity, but often include severe itching, swollen skin, and other secondary skin conditions. Other symptoms can include fever, headache, muscle pain, low blood pressure, and rapid heart rate. In severe cases, the reaction can lead to serious complications such as shock, and in rare cases, death.

Treatment

Treatment of the Mazzotti reaction typically involves the administration of antihistamines or corticosteroids to help manage the symptoms. In severe cases, hospitalization may be required.

See also

• Onchocerciasis
• Ivermectin
• Parasitic diseases

References

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