5F-EMB-PINACA

Synthetic cannabinoid

5F-EMB-PINACA
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5F-EMB-PINACA is a synthetic cannabinoid that has been used in scientific research and is a potent agonist of the cannabinoid receptors. It is structurally related to other synthetic cannabinoids such as AB-PINACA and 5F-AB-PINACA.

Chemical structure

5F-EMB-PINACA is classified as an indazole-based synthetic cannabinoid. Its chemical structure includes a 5-fluoropentyl chain attached to the indazole core, which is a common feature in many synthetic cannabinoids. The compound also contains an amide linkage to a valine methyl ester moiety, which contributes to its binding affinity and potency at the cannabinoid receptors.

Pharmacology

5F-EMB-PINACA acts as a full agonist at the CB₁ and CB₂ receptors, which are part of the endocannabinoid system. This system is involved in regulating various physiological processes including mood, memory, and pain sensation. The activation of these receptors by 5F-EMB-PINACA can lead to psychoactive effects similar to those produced by tetrahydrocannabinol (THC), the active component of cannabis.

Legal status

Due to its potential for abuse and lack of medical use, 5F-EMB-PINACA has been classified as a controlled substance in several countries. It is often included in the category of "new psychoactive substances" (NPS), which are synthetic drugs designed to mimic the effects of traditional illicit drugs.

Health effects

The use of 5F-EMB-PINACA has been associated with adverse health effects, including tachycardia, hypertension, nausea, and hallucinations. In severe cases, it can lead to acute kidney injury and seizures. The variability in potency and purity of synthetic cannabinoids like 5F-EMB-PINACA increases the risk of overdose and other harmful effects.

Synthesis

The synthesis of 5F-EMB-PINACA involves the reaction of an indazole core with a fluorinated alkyl chain and an amino acid derivative. The process requires careful control of reaction conditions to ensure the correct stereochemistry and purity of the final product.

Related pages

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• New psychoactive substances

Gallery

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  Chemical structure of 5F-EMB-PINACA