HOXC10

HOXC10 is a gene that belongs to the homeobox family of genes. The protein encoded by this gene is part of the Hox gene family, which plays a crucial role in morphogenesis and the development of the body plan.

Function

The HOXC10 gene is involved in the regulation of cell differentiation and body segmentation during embryonic development. It is expressed in a variety of tissues, including the central nervous system, skeletal muscle, and reproductive system. The protein encoded by the HOXC10 gene acts as a transcription factor, binding to specific DNA sequences and regulating the expression of other genes.

Clinical Significance

Mutations in the HOXC10 gene have been associated with several medical conditions. For instance, aberrant expression of HOXC10 has been linked to the progression of cancer, particularly in breast cancer and ovarian cancer. It has also been implicated in the development of endometriosis, a painful condition in which tissue similar to the lining of the uterus grows outside the uterus.

Research

Research into the HOXC10 gene is ongoing, with scientists seeking to better understand its role in development and disease. This research could potentially lead to new treatments for conditions associated with HOXC10 mutations.

File:HOXC10 gene location on human chromosome 12.png

Location of the HOXC10 gene on human chromosome 12.

See Also

• Homeobox
• Hox gene
• Transcription factor
• Breast cancer
• Ovarian cancer
• Endometriosis

References

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