Pustular psoriasis: Difference between revisions
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{{SI}} | |||
{{Infobox medical condition | |||
| name = Pustular psoriasis | |||
| image = [[File:Psoriasis_manum.jpg|left|thumb|Pustular psoriasis on the hand]] | |||
| caption = Pustular psoriasis on the hand | |||
| field = [[Dermatology]] | |||
| synonyms = | |||
| symptoms = [[Redness]], [[scaling]], [[pustules]] | |||
| complications = [[Secondary infection]], [[erythroderma]] | |||
| onset = Any age, often in [[adulthood]] | |||
| duration = Chronic | |||
| causes = [[Genetic factors]], [[immune system]] dysfunction | |||
| risks = [[Smoking]], [[stress]], [[infection]], [[pregnancy]] | |||
| diagnosis = [[Clinical examination]], [[skin biopsy]] | |||
| differential = [[Impetigo]], [[dermatitis]], [[fungal infection]] | |||
| treatment = [[Topical corticosteroids]], [[systemic therapy]], [[biologics]] | |||
| medication = [[Methotrexate]], [[cyclosporine]], [[acitretin]] | |||
| frequency = Rare | |||
| deaths = Rarely life-threatening | |||
}} | |||
{{Short description|A type of psoriasis characterized by pustules}} | {{Short description|A type of psoriasis characterized by pustules}} | ||
{{Psoriasis}} | {{Psoriasis}} | ||
'''Pustular psoriasis''' is a rare form of [[psoriasis]] characterized by the presence of pustules, or small blisters filled with non-infectious pus, on the skin. This condition can be localized or generalized and is often accompanied by systemic symptoms such as fever and malaise. | '''Pustular psoriasis''' is a rare form of [[psoriasis]] characterized by the presence of pustules, or small blisters filled with non-infectious pus, on the skin. This condition can be localized or generalized and is often accompanied by systemic symptoms such as fever and malaise. | ||
== Types == | == Types == | ||
Pustular psoriasis can be classified into several types based on the distribution and severity of the pustules: | Pustular psoriasis can be classified into several types based on the distribution and severity of the pustules: | ||
=== Generalized pustular psoriasis === | === Generalized pustular psoriasis === | ||
Generalized pustular psoriasis (GPP), also known as von Zumbusch psoriasis, is a severe form that can cover large areas of the body. It is often associated with systemic symptoms such as fever, chills, and fatigue. GPP can be life-threatening and requires immediate medical attention. | Generalized pustular psoriasis (GPP), also known as von Zumbusch psoriasis, is a severe form that can cover large areas of the body. It is often associated with systemic symptoms such as fever, chills, and fatigue. GPP can be life-threatening and requires immediate medical attention. | ||
=== Localized pustular psoriasis === | === Localized pustular psoriasis === | ||
Localized pustular psoriasis includes: | Localized pustular psoriasis includes: | ||
* '''Palmoplantar pustulosis''': This type affects the palms of the hands and the soles of the feet. It is characterized by the presence of pustules and scaling in these areas. | * '''Palmoplantar pustulosis''': This type affects the palms of the hands and the soles of the feet. It is characterized by the presence of pustules and scaling in these areas. | ||
* '''Acrodermatitis continua of Hallopeau''': This rare form affects the tips of the fingers and toes, often leading to nail changes and loss. | * '''Acrodermatitis continua of Hallopeau''': This rare form affects the tips of the fingers and toes, often leading to nail changes and loss. | ||
== Pathophysiology == | == Pathophysiology == | ||
The exact cause of pustular psoriasis is not fully understood, but it is believed to involve a combination of genetic, immune, and environmental factors. The condition is thought to result from an abnormal immune response that leads to the rapid turnover of skin cells and the formation of pustules. | The exact cause of pustular psoriasis is not fully understood, but it is believed to involve a combination of genetic, immune, and environmental factors. The condition is thought to result from an abnormal immune response that leads to the rapid turnover of skin cells and the formation of pustules. | ||
== Symptoms == | == Symptoms == | ||
The primary symptom of pustular psoriasis is the appearance of pustules on the skin. These pustules are typically surrounded by red, inflamed skin and may be accompanied by: | The primary symptom of pustular psoriasis is the appearance of pustules on the skin. These pustules are typically surrounded by red, inflamed skin and may be accompanied by: | ||
* Fever | * Fever | ||
* Chills | * Chills | ||
* Fatigue | * Fatigue | ||
* Muscle weakness | * Muscle weakness | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of pustular psoriasis is based on clinical examination and the characteristic appearance of the pustules. A skin biopsy may be performed to confirm the diagnosis and rule out other conditions. | Diagnosis of pustular psoriasis is based on clinical examination and the characteristic appearance of the pustules. A skin biopsy may be performed to confirm the diagnosis and rule out other conditions. | ||
== Treatment == | == Treatment == | ||
Treatment of pustular psoriasis depends on the severity and extent of the disease. Options include: | Treatment of pustular psoriasis depends on the severity and extent of the disease. Options include: | ||
* Topical treatments such as corticosteroids and vitamin D analogs | * Topical treatments such as corticosteroids and vitamin D analogs | ||
* Systemic treatments including retinoids, methotrexate, and cyclosporine | * Systemic treatments including retinoids, methotrexate, and cyclosporine | ||
* Biologic therapies targeting specific immune pathways | * Biologic therapies targeting specific immune pathways | ||
* Phototherapy | * Phototherapy | ||
== Prognosis == | == Prognosis == | ||
The prognosis for pustular psoriasis varies depending on the type and severity of the condition. While localized forms may be managed effectively with treatment, generalized pustular psoriasis can be life-threatening and requires aggressive management. | The prognosis for pustular psoriasis varies depending on the type and severity of the condition. While localized forms may be managed effectively with treatment, generalized pustular psoriasis can be life-threatening and requires aggressive management. | ||
== See also == | |||
== | |||
* [[Psoriasis]] | * [[Psoriasis]] | ||
* [[Dermatology]] | * [[Dermatology]] | ||
* [[Autoimmune disease]] | * [[Autoimmune disease]] | ||
[[Category:Psoriasis]] | [[Category:Psoriasis]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
Revision as of 15:57, 8 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD's medical weight loss NYC, sleep center NYC
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| Pustular psoriasis | |
|---|---|
| Synonyms | |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Redness, scaling, pustules |
| Complications | Secondary infection, erythroderma |
| Onset | Any age, often in adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Genetic factors, immune system dysfunction |
| Risks | Smoking, stress, infection, pregnancy |
| Diagnosis | Clinical examination, skin biopsy |
| Differential diagnosis | Impetigo, dermatitis, fungal infection |
| Prevention | N/A |
| Treatment | Topical corticosteroids, systemic therapy, biologics |
| Medication | Methotrexate, cyclosporine, acitretin |
| Prognosis | N/A |
| Frequency | Rare |
| Deaths | Rarely life-threatening |
A type of psoriasis characterized by pustules
Template:Psoriasis
Pustular psoriasis is a rare form of psoriasis characterized by the presence of pustules, or small blisters filled with non-infectious pus, on the skin. This condition can be localized or generalized and is often accompanied by systemic symptoms such as fever and malaise.
Types
Pustular psoriasis can be classified into several types based on the distribution and severity of the pustules:
Generalized pustular psoriasis
Generalized pustular psoriasis (GPP), also known as von Zumbusch psoriasis, is a severe form that can cover large areas of the body. It is often associated with systemic symptoms such as fever, chills, and fatigue. GPP can be life-threatening and requires immediate medical attention.
Localized pustular psoriasis
Localized pustular psoriasis includes:
- Palmoplantar pustulosis: This type affects the palms of the hands and the soles of the feet. It is characterized by the presence of pustules and scaling in these areas.
- Acrodermatitis continua of Hallopeau: This rare form affects the tips of the fingers and toes, often leading to nail changes and loss.
Pathophysiology
The exact cause of pustular psoriasis is not fully understood, but it is believed to involve a combination of genetic, immune, and environmental factors. The condition is thought to result from an abnormal immune response that leads to the rapid turnover of skin cells and the formation of pustules.
Symptoms
The primary symptom of pustular psoriasis is the appearance of pustules on the skin. These pustules are typically surrounded by red, inflamed skin and may be accompanied by:
- Fever
- Chills
- Fatigue
- Muscle weakness
Diagnosis
Diagnosis of pustular psoriasis is based on clinical examination and the characteristic appearance of the pustules. A skin biopsy may be performed to confirm the diagnosis and rule out other conditions.
Treatment
Treatment of pustular psoriasis depends on the severity and extent of the disease. Options include:
- Topical treatments such as corticosteroids and vitamin D analogs
- Systemic treatments including retinoids, methotrexate, and cyclosporine
- Biologic therapies targeting specific immune pathways
- Phototherapy
Prognosis
The prognosis for pustular psoriasis varies depending on the type and severity of the condition. While localized forms may be managed effectively with treatment, generalized pustular psoriasis can be life-threatening and requires aggressive management.
