Mast cell leukemia: Difference between revisions
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
{{SI}} | |||
{{Infobox medical condition | |||
| name = Mast cell leukemia | |||
| image = [[File:Mast_cell_leukemia.jpg]] | |||
| caption = Micrograph of mast cell leukemia, showing numerous mast cells | |||
| field = [[Hematology]] | |||
| symptoms = Fatigue, weight loss, fever, skin lesions, abdominal pain | |||
| complications = [[Anemia]], [[thrombocytopenia]], [[hepatosplenomegaly]], [[gastrointestinal bleeding]] | |||
| onset = Typically in adulthood | |||
| duration = Chronic | |||
| causes = [[Genetic mutations]] in mast cells | |||
| risks = Unknown | |||
| diagnosis = [[Bone marrow biopsy]], [[blood test]] | |||
| differential = [[Systemic mastocytosis]], [[acute myeloid leukemia]] | |||
| treatment = [[Chemotherapy]], [[tyrosine kinase inhibitors]], [[stem cell transplant]] | |||
| prognosis = Poor | |||
| frequency = Very rare | |||
}} | |||
'''Mast cell leukemia''' is a rare and aggressive subtype of [[Systemic mastocytosis|systemic mastocytosis]] characterized by the proliferation of [[Mast cell|mast cells]] in the [[Bone marrow|bone marrow]] and other organs. It is classified as a [[Myeloproliferative neoplasm|myeloproliferative neoplasm]] and is associated with a poor prognosis. | '''Mast cell leukemia''' is a rare and aggressive subtype of [[Systemic mastocytosis|systemic mastocytosis]] characterized by the proliferation of [[Mast cell|mast cells]] in the [[Bone marrow|bone marrow]] and other organs. It is classified as a [[Myeloproliferative neoplasm|myeloproliferative neoplasm]] and is associated with a poor prognosis. | ||
== Signs and symptoms == | == Signs and symptoms == | ||
Patients with mast cell leukemia often present with symptoms related to the infiltration of mast cells into various organs. These can include [[Fatigue (medical)|fatigue]], [[Weight loss|weight loss]], [[Fever|fever]], and [[Abdominal pain|abdominal pain]]. In addition, the release of [[Histamine|histamine]] and other mediators from mast cells can cause [[Flushing (physiology)|flushing]], [[Pruritus|itching]], [[Diarrhea|diarrhea]], and [[Anaphylaxis|anaphylactic reactions]]. | Patients with mast cell leukemia often present with symptoms related to the infiltration of mast cells into various organs. These can include [[Fatigue (medical)|fatigue]], [[Weight loss|weight loss]], [[Fever|fever]], and [[Abdominal pain|abdominal pain]]. In addition, the release of [[Histamine|histamine]] and other mediators from mast cells can cause [[Flushing (physiology)|flushing]], [[Pruritus|itching]], [[Diarrhea|diarrhea]], and [[Anaphylaxis|anaphylactic reactions]]. | ||
== Diagnosis == | == Diagnosis == | ||
The diagnosis of mast cell leukemia is based on the presence of mast cells in the bone marrow and other tissues, as well as the presence of certain [[Mutation|mutations]] in the [[KIT (gene)|KIT gene]]. Other diagnostic tests can include [[Blood test|blood tests]], [[Bone marrow examination|bone marrow examination]], and [[Genetic testing|genetic testing]]. | The diagnosis of mast cell leukemia is based on the presence of mast cells in the bone marrow and other tissues, as well as the presence of certain [[Mutation|mutations]] in the [[KIT (gene)|KIT gene]]. Other diagnostic tests can include [[Blood test|blood tests]], [[Bone marrow examination|bone marrow examination]], and [[Genetic testing|genetic testing]]. | ||
== Treatment == | == Treatment == | ||
Treatment for mast cell leukemia is typically aggressive and can include [[Chemotherapy|chemotherapy]], [[Stem cell transplantation|stem cell transplantation]], and targeted therapies such as [[Tyrosine kinase inhibitor|tyrosine kinase inhibitors]]. | Treatment for mast cell leukemia is typically aggressive and can include [[Chemotherapy|chemotherapy]], [[Stem cell transplantation|stem cell transplantation]], and targeted therapies such as [[Tyrosine kinase inhibitor|tyrosine kinase inhibitors]]. | ||
== Prognosis == | == Prognosis == | ||
The prognosis for mast cell leukemia is generally poor, with a median survival time of less than a year. However, some patients may respond well to treatment and achieve a longer survival time. | The prognosis for mast cell leukemia is generally poor, with a median survival time of less than a year. However, some patients may respond well to treatment and achieve a longer survival time. | ||
== See also == | == See also == | ||
* [[Mastocytosis]] | * [[Mastocytosis]] | ||
* [[Leukemia]] | * [[Leukemia]] | ||
* [[Myeloproliferative neoplasm]] | * [[Myeloproliferative neoplasm]] | ||
== References == | == References == | ||
<references /> | <references /> | ||
[[Category:Leukemia]] | [[Category:Leukemia]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Myeloproliferative neoplasms]] | [[Category:Myeloproliferative neoplasms]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 21:43, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Mast cell leukemia | |
|---|---|
| |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Fatigue, weight loss, fever, skin lesions, abdominal pain |
| Complications | Anemia, thrombocytopenia, hepatosplenomegaly, gastrointestinal bleeding |
| Onset | Typically in adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Genetic mutations in mast cells |
| Risks | Unknown |
| Diagnosis | Bone marrow biopsy, blood test |
| Differential diagnosis | Systemic mastocytosis, acute myeloid leukemia |
| Prevention | N/A |
| Treatment | Chemotherapy, tyrosine kinase inhibitors, stem cell transplant |
| Medication | N/A |
| Prognosis | Poor |
| Frequency | Very rare |
| Deaths | N/A |
Mast cell leukemia is a rare and aggressive subtype of systemic mastocytosis characterized by the proliferation of mast cells in the bone marrow and other organs. It is classified as a myeloproliferative neoplasm and is associated with a poor prognosis.
Signs and symptoms[edit]
Patients with mast cell leukemia often present with symptoms related to the infiltration of mast cells into various organs. These can include fatigue, weight loss, fever, and abdominal pain. In addition, the release of histamine and other mediators from mast cells can cause flushing, itching, diarrhea, and anaphylactic reactions.
Diagnosis[edit]
The diagnosis of mast cell leukemia is based on the presence of mast cells in the bone marrow and other tissues, as well as the presence of certain mutations in the KIT gene. Other diagnostic tests can include blood tests, bone marrow examination, and genetic testing.
Treatment[edit]
Treatment for mast cell leukemia is typically aggressive and can include chemotherapy, stem cell transplantation, and targeted therapies such as tyrosine kinase inhibitors.
Prognosis[edit]
The prognosis for mast cell leukemia is generally poor, with a median survival time of less than a year. However, some patients may respond well to treatment and achieve a longer survival time.
See also[edit]
References[edit]
<references />
