Hürthle cell: Difference between revisions
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
{{SI}} | |||
{{Infobox medical condition | |||
| name = Hürthle cell | |||
| image = [[File:Cytopathology_suspicious_for_Hürthle_cell_neoplasm,_annotated.png|250px]] | |||
| caption = Cytopathology suspicious for Hürthle cell neoplasm | |||
| field = [[Endocrinology]] | |||
| synonyms = [[Askanazy cell]], [[oncocytic cell]] | |||
| symptoms = [[Thyroid nodule]], [[hoarseness]], [[dysphagia]] | |||
| complications = [[Thyroid cancer]] | |||
| onset = Typically in [[adulthood]] | |||
| duration = Variable | |||
| causes = [[Genetic mutations]], [[radiation exposure]] | |||
| risks = [[Family history]], [[iodine deficiency]] | |||
| diagnosis = [[Fine needle aspiration]], [[ultrasound]] | |||
| differential = [[Follicular thyroid carcinoma]], [[papillary thyroid carcinoma]] | |||
| prevention = [[Regular screening]] in high-risk individuals | |||
| treatment = [[Surgery]], [[radioactive iodine therapy]] | |||
| prognosis = Generally good with treatment | |||
| frequency = Rare | |||
}} | |||
'''Hürthle cell''' (also known as '''oxyphil cell''' or '''Askanazy cell''') is a type of cell found in the [[thyroid gland]]. Named after the German pathologist [[Karl Hürthle]], these cells are characterized by their large size, abundant granular [[cytoplasm]], and distinct, large [[nucleus]]. | '''Hürthle cell''' (also known as '''oxyphil cell''' or '''Askanazy cell''') is a type of cell found in the [[thyroid gland]]. Named after the German pathologist [[Karl Hürthle]], these cells are characterized by their large size, abundant granular [[cytoplasm]], and distinct, large [[nucleus]]. | ||
== Characteristics == | == Characteristics == | ||
Hürthle cells are larger than typical [[follicular cells]] of the thyroid. They contain abundant, granular, eosinophilic cytoplasm due to the presence of numerous [[mitochondria]]. The nucleus of a Hürthle cell is large, round, and centrally located. | Hürthle cells are larger than typical [[follicular cells]] of the thyroid. They contain abundant, granular, eosinophilic cytoplasm due to the presence of numerous [[mitochondria]]. The nucleus of a Hürthle cell is large, round, and centrally located. | ||
== Function == | == Function == | ||
Hürthle cells are involved in the production of [[thyroid hormones]], which are essential for regulating the body's metabolism. They are also responsible for the uptake and concentration of [[iodine]], which is a crucial step in thyroid hormone synthesis. | Hürthle cells are involved in the production of [[thyroid hormones]], which are essential for regulating the body's metabolism. They are also responsible for the uptake and concentration of [[iodine]], which is a crucial step in thyroid hormone synthesis. | ||
== Clinical significance == | == Clinical significance == | ||
Hürthle cells are often associated with certain types of [[thyroid disease]], including [[Hashimoto's thyroiditis]], [[Graves' disease]], and [[thyroid cancer]]. In particular, a proliferation of Hürthle cells can lead to the formation of a Hürthle cell adenoma or carcinoma. | Hürthle cells are often associated with certain types of [[thyroid disease]], including [[Hashimoto's thyroiditis]], [[Graves' disease]], and [[thyroid cancer]]. In particular, a proliferation of Hürthle cells can lead to the formation of a Hürthle cell adenoma or carcinoma. | ||
=== Hürthle cell adenoma === | === Hürthle cell adenoma === | ||
A [[Hürthle cell adenoma]] is a benign tumor of the thyroid that is composed entirely of Hürthle cells. It is typically non-functioning, meaning it does not produce excess thyroid hormone. | A [[Hürthle cell adenoma]] is a benign tumor of the thyroid that is composed entirely of Hürthle cells. It is typically non-functioning, meaning it does not produce excess thyroid hormone. | ||
=== Hürthle cell carcinoma === | === Hürthle cell carcinoma === | ||
[[Hürthle cell carcinoma]] is a rare form of thyroid cancer that is derived from Hürthle cells. It is often aggressive and has a poorer prognosis compared to other types of thyroid cancer. | [[Hürthle cell carcinoma]] is a rare form of thyroid cancer that is derived from Hürthle cells. It is often aggressive and has a poorer prognosis compared to other types of thyroid cancer. | ||
== See also == | == See also == | ||
* [[Thyroid]] | * [[Thyroid]] | ||
* [[Thyroid disease]] | * [[Thyroid disease]] | ||
* [[Thyroid hormones]] | * [[Thyroid hormones]] | ||
* [[Thyroid cancer]] | * [[Thyroid cancer]] | ||
[[Category:Cell biology]] | [[Category:Cell biology]] | ||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
[[Category:Thyroid]] | [[Category:Thyroid]] | ||
{{Medicine-stub}} | {{Medicine-stub}} | ||
Latest revision as of 03:07, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Hürthle cell | |
|---|---|
| |
| Synonyms | Askanazy cell, oncocytic cell |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Thyroid nodule, hoarseness, dysphagia |
| Complications | Thyroid cancer |
| Onset | Typically in adulthood |
| Duration | Variable |
| Types | N/A |
| Causes | Genetic mutations, radiation exposure |
| Risks | Family history, iodine deficiency |
| Diagnosis | Fine needle aspiration, ultrasound |
| Differential diagnosis | Follicular thyroid carcinoma, papillary thyroid carcinoma |
| Prevention | Regular screening in high-risk individuals |
| Treatment | Surgery, radioactive iodine therapy |
| Medication | N/A |
| Prognosis | Generally good with treatment |
| Frequency | Rare |
| Deaths | N/A |
Hürthle cell (also known as oxyphil cell or Askanazy cell) is a type of cell found in the thyroid gland. Named after the German pathologist Karl Hürthle, these cells are characterized by their large size, abundant granular cytoplasm, and distinct, large nucleus.
Characteristics[edit]
Hürthle cells are larger than typical follicular cells of the thyroid. They contain abundant, granular, eosinophilic cytoplasm due to the presence of numerous mitochondria. The nucleus of a Hürthle cell is large, round, and centrally located.
Function[edit]
Hürthle cells are involved in the production of thyroid hormones, which are essential for regulating the body's metabolism. They are also responsible for the uptake and concentration of iodine, which is a crucial step in thyroid hormone synthesis.
Clinical significance[edit]
Hürthle cells are often associated with certain types of thyroid disease, including Hashimoto's thyroiditis, Graves' disease, and thyroid cancer. In particular, a proliferation of Hürthle cells can lead to the formation of a Hürthle cell adenoma or carcinoma.
Hürthle cell adenoma[edit]
A Hürthle cell adenoma is a benign tumor of the thyroid that is composed entirely of Hürthle cells. It is typically non-functioning, meaning it does not produce excess thyroid hormone.
Hürthle cell carcinoma[edit]
Hürthle cell carcinoma is a rare form of thyroid cancer that is derived from Hürthle cells. It is often aggressive and has a poorer prognosis compared to other types of thyroid cancer.
See also[edit]
