Diffuse proliferative nephritis: Difference between revisions
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{{Infobox medical condition | |||
| name = Diffuse proliferative nephritis | |||
| image = [[File:Diffuse_proliferative_lupus_nephritis.jpg|250px]] | |||
| caption = Micrograph of diffuse proliferative lupus nephritis, a type of diffuse proliferative nephritis | |||
| field = [[Nephrology]] | |||
| synonyms = Diffuse proliferative glomerulonephritis | |||
| symptoms = [[Hematuria]], [[proteinuria]], [[hypertension]], [[edema]] | |||
| complications = [[Chronic kidney disease]], [[end-stage renal disease]] | |||
| onset = Variable | |||
| duration = Chronic | |||
| causes = Often associated with [[systemic lupus erythematosus]] | |||
| risks = [[Autoimmune disorders]], [[genetic predisposition]] | |||
| diagnosis = [[Urinalysis]], [[renal biopsy]], [[serology]] | |||
| differential = [[Focal segmental glomerulosclerosis]], [[membranous nephropathy]] | |||
| treatment = [[Immunosuppressive therapy]], [[corticosteroids]], [[antihypertensive drugs]] | |||
| prognosis = Variable, depends on response to treatment | |||
| frequency = Rare | |||
}} | |||
'''Diffuse proliferative nephritis''' is a type of [[glomerulonephritis]] that is characterized by significant inflammation and proliferation of the cells within the [[glomerulus]] of the kidney. This condition can lead to significant kidney damage and, in severe cases, [[kidney failure]]. | '''Diffuse proliferative nephritis''' is a type of [[glomerulonephritis]] that is characterized by significant inflammation and proliferation of the cells within the [[glomerulus]] of the kidney. This condition can lead to significant kidney damage and, in severe cases, [[kidney failure]]. | ||
== Causes == | == Causes == | ||
Diffuse proliferative nephritis is often caused by an overactive [[immune system]] that mistakenly attacks the kidneys. This can occur as a result of certain diseases, such as [[systemic lupus erythematosus]] (SLE), [[Goodpasture's syndrome]], and [[vasculitis]]. In some cases, the exact cause of diffuse proliferative nephritis is unknown. | Diffuse proliferative nephritis is often caused by an overactive [[immune system]] that mistakenly attacks the kidneys. This can occur as a result of certain diseases, such as [[systemic lupus erythematosus]] (SLE), [[Goodpasture's syndrome]], and [[vasculitis]]. In some cases, the exact cause of diffuse proliferative nephritis is unknown. | ||
== Symptoms == | == Symptoms == | ||
The symptoms of diffuse proliferative nephritis can vary greatly depending on the severity of the condition. Common symptoms include [[blood in the urine]] (hematuria), [[protein in the urine]] (proteinuria), and [[high blood pressure]] (hypertension). Other symptoms may include [[swelling]] (edema), particularly in the legs and feet, and [[fatigue]]. | The symptoms of diffuse proliferative nephritis can vary greatly depending on the severity of the condition. Common symptoms include [[blood in the urine]] (hematuria), [[protein in the urine]] (proteinuria), and [[high blood pressure]] (hypertension). Other symptoms may include [[swelling]] (edema), particularly in the legs and feet, and [[fatigue]]. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of diffuse proliferative nephritis typically involves a combination of [[medical history]], physical examination, and laboratory tests. These tests may include [[urinalysis]], [[blood tests]], and a [[kidney biopsy]]. | Diagnosis of diffuse proliferative nephritis typically involves a combination of [[medical history]], physical examination, and laboratory tests. These tests may include [[urinalysis]], [[blood tests]], and a [[kidney biopsy]]. | ||
== Treatment == | == Treatment == | ||
Treatment for diffuse proliferative nephritis typically involves managing the symptoms and slowing the progression of the disease. This may include medications to control high blood pressure, reduce proteinuria, and suppress the immune system. In severe cases, [[dialysis]] or a [[kidney transplant]] may be necessary. | Treatment for diffuse proliferative nephritis typically involves managing the symptoms and slowing the progression of the disease. This may include medications to control high blood pressure, reduce proteinuria, and suppress the immune system. In severe cases, [[dialysis]] or a [[kidney transplant]] may be necessary. | ||
== Diffuse_proliferative_nephritis gallery == | |||
<gallery> | |||
File:Diffuse_proliferative_lupus_nephritis_-_high_mag.jpg|Diffuse proliferative lupus nephritis - high magnification | |||
File:Renal_corpuscle-en.svg|Renal corpuscle diagram | |||
</gallery> | |||
== See also == | == See also == | ||
* [[Glomerulonephritis]] | * [[Glomerulonephritis]] | ||
* [[Systemic lupus erythematosus]] | * [[Systemic lupus erythematosus]] | ||
| Line 26: | Line 40: | ||
* [[Dialysis]] | * [[Dialysis]] | ||
* [[Kidney transplant]] | * [[Kidney transplant]] | ||
[[Category:Kidney diseases]] | [[Category:Kidney diseases]] | ||
[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
[[Category:Nephrology]] | [[Category:Nephrology]] | ||
{{stub}} | {{stub}} | ||
{{dictionary-stub1}} | {{dictionary-stub1}} | ||
Latest revision as of 00:59, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Diffuse proliferative nephritis | |
|---|---|
| |
| Synonyms | Diffuse proliferative glomerulonephritis |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Hematuria, proteinuria, hypertension, edema |
| Complications | Chronic kidney disease, end-stage renal disease |
| Onset | Variable |
| Duration | Chronic |
| Types | N/A |
| Causes | Often associated with systemic lupus erythematosus |
| Risks | Autoimmune disorders, genetic predisposition |
| Diagnosis | Urinalysis, renal biopsy, serology |
| Differential diagnosis | Focal segmental glomerulosclerosis, membranous nephropathy |
| Prevention | N/A |
| Treatment | Immunosuppressive therapy, corticosteroids, antihypertensive drugs |
| Medication | N/A |
| Prognosis | Variable, depends on response to treatment |
| Frequency | Rare |
| Deaths | N/A |
Diffuse proliferative nephritis is a type of glomerulonephritis that is characterized by significant inflammation and proliferation of the cells within the glomerulus of the kidney. This condition can lead to significant kidney damage and, in severe cases, kidney failure.
Causes[edit]
Diffuse proliferative nephritis is often caused by an overactive immune system that mistakenly attacks the kidneys. This can occur as a result of certain diseases, such as systemic lupus erythematosus (SLE), Goodpasture's syndrome, and vasculitis. In some cases, the exact cause of diffuse proliferative nephritis is unknown.
Symptoms[edit]
The symptoms of diffuse proliferative nephritis can vary greatly depending on the severity of the condition. Common symptoms include blood in the urine (hematuria), protein in the urine (proteinuria), and high blood pressure (hypertension). Other symptoms may include swelling (edema), particularly in the legs and feet, and fatigue.
Diagnosis[edit]
Diagnosis of diffuse proliferative nephritis typically involves a combination of medical history, physical examination, and laboratory tests. These tests may include urinalysis, blood tests, and a kidney biopsy.
Treatment[edit]
Treatment for diffuse proliferative nephritis typically involves managing the symptoms and slowing the progression of the disease. This may include medications to control high blood pressure, reduce proteinuria, and suppress the immune system. In severe cases, dialysis or a kidney transplant may be necessary.
Diffuse_proliferative_nephritis gallery[edit]
-
Diffuse proliferative lupus nephritis - high magnification -
Renal corpuscle diagram
