Amyloid purpura: Difference between revisions
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{{SI}}<br> | |||
{{Infobox medical condition | |||
| name = Amyloid purpura | |||
| image = [[File:Purpura.jpg|thumb|Purpura rash on the skin]] | |||
| caption = Purpura rash on the skin | |||
| field = [[Dermatology]], [[Hematology]] | |||
| symptoms = [[Purpura]], [[bruising]], [[bleeding]] | |||
| complications = [[Kidney failure]], [[heart failure]] | |||
| onset = Varies | |||
| duration = Chronic | |||
| causes = [[Amyloidosis]] | |||
| risks = [[Multiple myeloma]], [[chronic inflammatory conditions]] | |||
| diagnosis = [[Biopsy]], [[blood tests]] | |||
| differential = [[Thrombocytopenia]], [[vasculitis]] | |||
| treatment = [[Chemotherapy]], [[stem cell transplant]] | |||
| medication = [[Dexamethasone]], [[bortezomib]] | |||
| prognosis = Variable, depends on underlying cause | |||
| frequency = Rare | |||
}} | |||
== Amyloid Purpura == | == Amyloid Purpura == | ||
'''Amyloid purpura''' is a clinical manifestation associated with [[amyloidosis]], a condition characterized by the abnormal deposition of amyloid proteins in various tissues and organs. This deposition can lead to a variety of symptoms, depending on the organs affected. Amyloid purpura specifically refers to the presence of purpura, or purple-colored spots and patches, on the skin due to bleeding underneath the skin. | '''Amyloid purpura''' is a clinical manifestation associated with [[amyloidosis]], a condition characterized by the abnormal deposition of amyloid proteins in various tissues and organs. This deposition can lead to a variety of symptoms, depending on the organs affected. Amyloid purpura specifically refers to the presence of purpura, or purple-colored spots and patches, on the skin due to bleeding underneath the skin. | ||
== Pathophysiology == | == Pathophysiology == | ||
Amyloid purpura occurs when amyloid deposits affect the [[blood vessels]] and [[capillaries]], leading to increased fragility and a tendency to bleed. The amyloid proteins can disrupt normal vascular function, causing small blood vessels to rupture easily. This results in the characteristic purpuric lesions seen in patients with amyloid purpura. | Amyloid purpura occurs when amyloid deposits affect the [[blood vessels]] and [[capillaries]], leading to increased fragility and a tendency to bleed. The amyloid proteins can disrupt normal vascular function, causing small blood vessels to rupture easily. This results in the characteristic purpuric lesions seen in patients with amyloid purpura. | ||
== Clinical Presentation == | == Clinical Presentation == | ||
Patients with amyloid purpura typically present with non-blanching purpuric spots on the skin. These spots are often found on areas of the body that are subject to pressure or trauma, such as the arms, legs, and trunk. The purpura can vary in size from small petechiae to larger ecchymoses. | Patients with amyloid purpura typically present with non-blanching purpuric spots on the skin. These spots are often found on areas of the body that are subject to pressure or trauma, such as the arms, legs, and trunk. The purpura can vary in size from small petechiae to larger ecchymoses. | ||
== Diagnosis == | == Diagnosis == | ||
The diagnosis of amyloid purpura involves a combination of clinical evaluation and laboratory tests. A skin biopsy may be performed to confirm the presence of amyloid deposits in the affected tissues. Additional tests, such as serum and urine protein electrophoresis, can help identify the type of amyloidosis and guide further management. | The diagnosis of amyloid purpura involves a combination of clinical evaluation and laboratory tests. A skin biopsy may be performed to confirm the presence of amyloid deposits in the affected tissues. Additional tests, such as serum and urine protein electrophoresis, can help identify the type of amyloidosis and guide further management. | ||
== Treatment == | == Treatment == | ||
Treatment of amyloid purpura focuses on managing the underlying amyloidosis. This may involve the use of medications to reduce amyloid production or promote its clearance from the body. In some cases, supportive care, such as the use of compression garments or topical treatments, may be recommended to manage symptoms. | Treatment of amyloid purpura focuses on managing the underlying amyloidosis. This may involve the use of medications to reduce amyloid production or promote its clearance from the body. In some cases, supportive care, such as the use of compression garments or topical treatments, may be recommended to manage symptoms. | ||
== Related Pages == | == Related Pages == | ||
* [[Amyloidosis]] | * [[Amyloidosis]] | ||
* [[Purpura]] | * [[Purpura]] | ||
* [[Blood vessel]] | * [[Blood vessel]] | ||
* [[Capillary]] | * [[Capillary]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
Latest revision as of 13:47, 4 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Amyloid purpura | |
|---|---|
 | |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Purpura, bruising, bleeding |
| Complications | Kidney failure, heart failure |
| Onset | Varies |
| Duration | Chronic |
| Types | N/A |
| Causes | Amyloidosis |
| Risks | Multiple myeloma, chronic inflammatory conditions |
| Diagnosis | Biopsy, blood tests |
| Differential diagnosis | Thrombocytopenia, vasculitis |
| Prevention | N/A |
| Treatment | Chemotherapy, stem cell transplant |
| Medication | Dexamethasone, bortezomib |
| Prognosis | Variable, depends on underlying cause |
| Frequency | Rare |
| Deaths | N/A |
Amyloid Purpura[edit]
Amyloid purpura is a clinical manifestation associated with amyloidosis, a condition characterized by the abnormal deposition of amyloid proteins in various tissues and organs. This deposition can lead to a variety of symptoms, depending on the organs affected. Amyloid purpura specifically refers to the presence of purpura, or purple-colored spots and patches, on the skin due to bleeding underneath the skin.
Pathophysiology[edit]
Amyloid purpura occurs when amyloid deposits affect the blood vessels and capillaries, leading to increased fragility and a tendency to bleed. The amyloid proteins can disrupt normal vascular function, causing small blood vessels to rupture easily. This results in the characteristic purpuric lesions seen in patients with amyloid purpura.
Clinical Presentation[edit]
Patients with amyloid purpura typically present with non-blanching purpuric spots on the skin. These spots are often found on areas of the body that are subject to pressure or trauma, such as the arms, legs, and trunk. The purpura can vary in size from small petechiae to larger ecchymoses.
Diagnosis[edit]
The diagnosis of amyloid purpura involves a combination of clinical evaluation and laboratory tests. A skin biopsy may be performed to confirm the presence of amyloid deposits in the affected tissues. Additional tests, such as serum and urine protein electrophoresis, can help identify the type of amyloidosis and guide further management.
Treatment[edit]
Treatment of amyloid purpura focuses on managing the underlying amyloidosis. This may involve the use of medications to reduce amyloid production or promote its clearance from the body. In some cases, supportive care, such as the use of compression garments or topical treatments, may be recommended to manage symptoms.
