Lipoatrophy: Difference between revisions
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{{Infobox medical condition | |||
| name = Lipoatrophy | |||
| synonyms = Lipodystrophy | |||
| field = [[Endocrinology]] | |||
| symptoms = Loss of [[adipose tissue]], [[skin]] thinning | |||
| complications = [[Insulin resistance]], [[dyslipidemia]] | |||
| onset = Variable | |||
| duration = Chronic | |||
| causes = [[Genetic disorder]], [[HIV]] treatment, [[autoimmune disease]] | |||
| risks = [[HIV]], [[antiretroviral therapy]], [[autoimmune conditions]] | |||
| diagnosis = [[Physical examination]], [[biopsy]] | |||
| differential = [[Lipohypertrophy]], [[Cushing's syndrome]] | |||
| treatment = [[Cosmetic surgery]], [[hormone replacement therapy]] | |||
| prognosis = Variable, depends on underlying cause | |||
| frequency = Rare | |||
}} | |||
'''Lipoatrophy''' is a medical condition characterized by the loss of subcutaneous fat in certain parts of the body. This condition can be localized, affecting specific areas, or generalized, affecting the entire body. Lipoatrophy can be caused by a variety of factors, including genetic disorders, autoimmune diseases, and certain medications. | '''Lipoatrophy''' is a medical condition characterized by the loss of subcutaneous fat in certain parts of the body. This condition can be localized, affecting specific areas, or generalized, affecting the entire body. Lipoatrophy can be caused by a variety of factors, including genetic disorders, autoimmune diseases, and certain medications. | ||
==Causes== | ==Causes== | ||
Lipoatrophy can be caused by a variety of factors. Some of the most common causes include: | Lipoatrophy can be caused by a variety of factors. Some of the most common causes include: | ||
* '''[[Genetic disorders]]''': Certain genetic disorders can cause lipoatrophy. For example, [[Berardinelli-Seip congenital lipodystrophy]] is a rare genetic disorder characterized by the near total absence of body fat. | * '''[[Genetic disorders]]''': Certain genetic disorders can cause lipoatrophy. For example, [[Berardinelli-Seip congenital lipodystrophy]] is a rare genetic disorder characterized by the near total absence of body fat. | ||
* '''[[Autoimmune diseases]]''': Some autoimmune diseases, such as [[systemic lupus erythematosus]] and [[dermatomyositis]], can cause lipoatrophy. | * '''[[Autoimmune diseases]]''': Some autoimmune diseases, such as [[systemic lupus erythematosus]] and [[dermatomyositis]], can cause lipoatrophy. | ||
* '''[[Medications]]''': Certain medications, particularly those used to treat [[HIV/AIDS]], can cause lipoatrophy. This is often referred to as "HIV-associated lipoatrophy." | * '''[[Medications]]''': Certain medications, particularly those used to treat [[HIV/AIDS]], can cause lipoatrophy. This is often referred to as "HIV-associated lipoatrophy." | ||
==Symptoms== | ==Symptoms== | ||
The primary symptom of lipoatrophy is the loss of subcutaneous fat in certain parts of the body. This can result in a variety of physical changes, including: | The primary symptom of lipoatrophy is the loss of subcutaneous fat in certain parts of the body. This can result in a variety of physical changes, including: | ||
* '''[[Muscle wasting]]''': The loss of subcutaneous fat can lead to muscle wasting, resulting in a thin, frail appearance. | * '''[[Muscle wasting]]''': The loss of subcutaneous fat can lead to muscle wasting, resulting in a thin, frail appearance. | ||
* '''[[Facial lipoatrophy]]''': This is characterized by the loss of fat in the face, leading to a gaunt, hollow-cheeked appearance. | * '''[[Facial lipoatrophy]]''': This is characterized by the loss of fat in the face, leading to a gaunt, hollow-cheeked appearance. | ||
* '''[[Insulin resistance]]''': In some cases, lipoatrophy can lead to insulin resistance, a condition that can increase the risk of developing [[type 2 diabetes]] and [[heart disease]]. | * '''[[Insulin resistance]]''': In some cases, lipoatrophy can lead to insulin resistance, a condition that can increase the risk of developing [[type 2 diabetes]] and [[heart disease]]. | ||
==Treatment== | ==Treatment== | ||
Treatment for lipoatrophy depends on the underlying cause. In cases where the condition is caused by medication, switching to a different medication may help. In other cases, treatment may involve managing the symptoms. For example, facial fillers can be used to improve the appearance of facial lipoatrophy. | Treatment for lipoatrophy depends on the underlying cause. In cases where the condition is caused by medication, switching to a different medication may help. In other cases, treatment may involve managing the symptoms. For example, facial fillers can be used to improve the appearance of facial lipoatrophy. | ||
==See also== | ==See also== | ||
* [[Lipodystrophy]] | * [[Lipodystrophy]] | ||
* [[HIV/AIDS]] | * [[HIV/AIDS]] | ||
* [[Autoimmune diseases]] | * [[Autoimmune diseases]] | ||
* [[Genetic disorders]] | * [[Genetic disorders]] | ||
[[Category:Medical conditions]] | [[Category:Medical conditions]] | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
[[Category:HIV/AIDS]] | [[Category:HIV/AIDS]] | ||
{{stub}} | {{stub}} | ||
{{No image}} | {{No image}} | ||
Latest revision as of 23:40, 3 April 2025
| Lipoatrophy | |
|---|---|
| Synonyms | Lipodystrophy |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Loss of adipose tissue, skin thinning |
| Complications | Insulin resistance, dyslipidemia |
| Onset | Variable |
| Duration | Chronic |
| Types | N/A |
| Causes | Genetic disorder, HIV treatment, autoimmune disease |
| Risks | HIV, antiretroviral therapy, autoimmune conditions |
| Diagnosis | Physical examination, biopsy |
| Differential diagnosis | Lipohypertrophy, Cushing's syndrome |
| Prevention | N/A |
| Treatment | Cosmetic surgery, hormone replacement therapy |
| Medication | N/A |
| Prognosis | Variable, depends on underlying cause |
| Frequency | Rare |
| Deaths | N/A |
Lipoatrophy is a medical condition characterized by the loss of subcutaneous fat in certain parts of the body. This condition can be localized, affecting specific areas, or generalized, affecting the entire body. Lipoatrophy can be caused by a variety of factors, including genetic disorders, autoimmune diseases, and certain medications.
Causes[edit]
Lipoatrophy can be caused by a variety of factors. Some of the most common causes include:
- Genetic disorders: Certain genetic disorders can cause lipoatrophy. For example, Berardinelli-Seip congenital lipodystrophy is a rare genetic disorder characterized by the near total absence of body fat.
- Autoimmune diseases: Some autoimmune diseases, such as systemic lupus erythematosus and dermatomyositis, can cause lipoatrophy.
- Medications: Certain medications, particularly those used to treat HIV/AIDS, can cause lipoatrophy. This is often referred to as "HIV-associated lipoatrophy."
Symptoms[edit]
The primary symptom of lipoatrophy is the loss of subcutaneous fat in certain parts of the body. This can result in a variety of physical changes, including:
- Muscle wasting: The loss of subcutaneous fat can lead to muscle wasting, resulting in a thin, frail appearance.
- Facial lipoatrophy: This is characterized by the loss of fat in the face, leading to a gaunt, hollow-cheeked appearance.
- Insulin resistance: In some cases, lipoatrophy can lead to insulin resistance, a condition that can increase the risk of developing type 2 diabetes and heart disease.
Treatment[edit]
Treatment for lipoatrophy depends on the underlying cause. In cases where the condition is caused by medication, switching to a different medication may help. In other cases, treatment may involve managing the symptoms. For example, facial fillers can be used to improve the appearance of facial lipoatrophy.
