Choroid plexus papilloma: Difference between revisions

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{{Refimprove|date=August 2013}}
{{Short description|A rare, benign tumor of the choroid plexus}}
{{Infobox medical condition (new)
{{Use dmy dates|date=October 2023}}
| name            = Choroid plexus papilloma
| synonyms        = Papilloma of the choroid plexus
| image          = Plexuspapillom Makroskopie.png
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| field          = [[Neurosurgery]]
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'''Choroid plexus papilloma''', also known as '''papilloma of the choroid plexus''', is a rare benign  neuroepithelial intraventricular [[WHO Grades of CNS Tumors|WHO grade I]] lesion found in the [[choroid plexus]].<ref name="pmid10940770">{{cite journal |vauthors=McEvoy AW, Harding BN, Phipps KP |title=Management of choroid plexus tumours in children: 20 years experience at a single neurosurgical centre |journal=Pediatr Neurosurg |volume=32 |issue=4 |pages=192–9 |date=April 2000 |pmid=10940770 |doi= 10.1159/000028933|url=http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=pne32192|display-authors=etal}}</ref>  It leads to increased [[cerebrospinal fluid]] production, thus causing increased [[intracranial pressure]] and [[hydrocephalus]].<ref name="AdunkaBuchman2010">{{cite book|author1=Oliver Adunka|author2=Craig Buchman|title=Otology, Neurotology, and Lateral Skull Base Surgery: An Illustrated Handbook|url=https://books.google.com/books?id=2kv-Z-L5UUAC&pg=PT353|accessdate=12 August 2013|date=11 October 2010|publisher=Thieme|isbn=978-3-13-149621-8|pages=353–}}</ref>
==Choroid Plexus Papilloma==


Choroid plexus papilloma occurs in the [[lateral ventricles]] of children and in the [[fourth ventricle]] of adults. This is unlike most other pediatric tumors and adult tumors, in which the locations of the tumors is reversed. In children, brain tumors are usually found in the [[infratentorial]] region and in adults, brain tumors are usually found in the [[supratentorial]] space. The relationship is reversed for choroid plexus papillomas.
'''Choroid plexus papilloma''' is a rare, benign [[tumor]] that arises from the [[choroid plexus]], a network of cells that produce [[cerebrospinal fluid]] (CSF) in the [[ventricular system]] of the [[brain]]. These tumors are most commonly found in children but can also occur in adults.


==Signs and symptoms==
==Pathophysiology==
Signs of the tumor resulting from increased [[intracranial pressure]] are present in 91% of patients, with [[vomiting]], [[homonymous hemianopia|homonymous visual field defects]] and [[headache]] being the most common symptoms.
The choroid plexus is located within the [[ventricles of the brain]], and its primary function is the production of CSF. A choroid plexus papilloma is a [[neoplasm]] that originates from the epithelial cells of the choroid plexus. These tumors are typically well-circumscribed and can lead to increased production of CSF, potentially causing [[hydrocephalus]] due to obstruction of CSF flow or overproduction.
Other symptoms are ear ringing and dizziness.


==Pathophysiology==
==Clinical Presentation==
The tumor is neuroectodermal in origin and similar in structure to a normal [[choroid plexus]]. They may be created by [[epithelial cell]]s of the [[choroid plexus]].
Patients with choroid plexus papilloma may present with symptoms related to increased intracranial pressure, such as [[headache]], [[nausea]], [[vomiting]], and [[papilledema]]. In infants, signs may include [[macrocephaly]] and [[bulging fontanelle]]. Neurological deficits may occur depending on the location and size of the tumor.


<gallery>
==Diagnosis==
Image:Choroid plexus papilloma micrograph.jpg|[[Micrograph]] of a choroid plexus papilloma. [[H&E stain]].
Diagnosis of choroid plexus papilloma is typically made through imaging studies. [[Magnetic resonance imaging]] (MRI) is the preferred modality, as it provides detailed images of the brain and can help differentiate between choroid plexus papilloma and other types of brain tumors. On MRI, these tumors often appear as well-defined, lobulated masses that enhance with contrast.
Image:Plexuspapillom Detail.jpg|Plexuspapillom Detail
Image:Plexuspapillom Overview.jpg|Plexuspapillom Overview
</gallery>


==Treatment==
==Treatment==
Choroid plexus papillomas are benign tumors that are usually cured by surgery; malignant progression has been rarely reported.
The primary treatment for choroid plexus papilloma is surgical resection. Complete removal of the tumor often results in a cure, as these tumors are benign and do not typically invade surrounding brain tissue. In cases where complete resection is not possible, additional treatments such as [[radiotherapy]] may be considered.
 
==Epidemiology==
Internationally tumors of the choroid plexus are rare, accounting for 0.4-0.6% of all intracranial neoplasms. It most commonly affects young children under the age of 5 with a mean patient age of 5.2 years.
 
==References==
{{reflist}}


== External links ==
==Prognosis==
{{Medical resources
The prognosis for patients with choroid plexus papilloma is generally favorable, especially when the tumor is completely resected. Recurrence is rare, and long-term outcomes are excellent in most cases. However, the presence of hydrocephalus may require additional management, such as the placement of a [[ventriculoperitoneal shunt]].
|  DiseasesDB    = 
|  ICD10          = {{ICD10|C|71|5|c|69}}
|  ICD9          = {{ICD9|191.5}}
|  ICDO          = {{ICDO|9390|1}}
|  OMIM          = 
|  MedlinePlus    = 
|  eMedicineSubj  = article
|  eMedicineTopic = 250795
|  eMedicine_mult = {{eMedicine2|radio|171}}
|  MeshID        = D020288
}}
{{Commonscat-inline}}
* [http://rad.usuhs.edu/medpix/medpix.html?mode=image_finder&action=search&srchstr=choroid%20plexus%20papilloma&srch_type=all#top Choroid Plexus Papilloma] MRI, CT, and pathology images from MedPix


{{Central nervous system tumors}}
==Related Pages==
{{CNS diseases of the nervous system}}
* [[Choroid plexus carcinoma]]
* [[Hydrocephalus]]
* [[Ventricular system]]
* [[Neoplasm]]


[[Category:Brain tumor]]
[[Category:Brain tumors]]
{{dictionary-stub1}}
[[Category:Neuro-oncology]]
<gallery>
[[Category:Pediatric cancers]]
File:Plexuspapillom Makroskopie.png|Choroid plexus papilloma
File:Choroid plexus papilloma micrograph.jpg|Choroid plexus papilloma
File:Plexuspapillom Detail.jpg|Choroid plexus papilloma
File:Plexuspapillom Overview.jpg|Choroid plexus papilloma
</gallery>

Revision as of 19:22, 22 March 2025

A rare, benign tumor of the choroid plexus



Choroid Plexus Papilloma

Choroid plexus papilloma is a rare, benign tumor that arises from the choroid plexus, a network of cells that produce cerebrospinal fluid (CSF) in the ventricular system of the brain. These tumors are most commonly found in children but can also occur in adults.

Pathophysiology

The choroid plexus is located within the ventricles of the brain, and its primary function is the production of CSF. A choroid plexus papilloma is a neoplasm that originates from the epithelial cells of the choroid plexus. These tumors are typically well-circumscribed and can lead to increased production of CSF, potentially causing hydrocephalus due to obstruction of CSF flow or overproduction.

Clinical Presentation

Patients with choroid plexus papilloma may present with symptoms related to increased intracranial pressure, such as headache, nausea, vomiting, and papilledema. In infants, signs may include macrocephaly and bulging fontanelle. Neurological deficits may occur depending on the location and size of the tumor.

Diagnosis

Diagnosis of choroid plexus papilloma is typically made through imaging studies. Magnetic resonance imaging (MRI) is the preferred modality, as it provides detailed images of the brain and can help differentiate between choroid plexus papilloma and other types of brain tumors. On MRI, these tumors often appear as well-defined, lobulated masses that enhance with contrast.

Treatment

The primary treatment for choroid plexus papilloma is surgical resection. Complete removal of the tumor often results in a cure, as these tumors are benign and do not typically invade surrounding brain tissue. In cases where complete resection is not possible, additional treatments such as radiotherapy may be considered.

Prognosis

The prognosis for patients with choroid plexus papilloma is generally favorable, especially when the tumor is completely resected. Recurrence is rare, and long-term outcomes are excellent in most cases. However, the presence of hydrocephalus may require additional management, such as the placement of a ventriculoperitoneal shunt.

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