Pregnenedione

Pregnenedione is a steroid and precursor in the biosynthesis of most of the steroid hormones, including the progestogens, glucocorticoids, mineralocorticoids, androgens, and estrogens. It is derived from cholesterol and is converted to progesterone by the enzyme 3β-hydroxysteroid dehydrogenase.

Chemical Structure and Properties

Pregnenedione is a 21-carbon steroid. It is also known as 5-pregnen-3β-ol-20-one. The molecular formula for pregnenedione is C21H32O2. It has a molecular weight of 316.48 g/mol.

Biosynthesis

The biosynthesis of pregnenedione involves several steps. It begins with the conversion of cholesterol to pregnenolone by the enzyme cholesterol side-chain cleavage enzyme. Pregnenolone is then converted to progesterone by the enzyme 3β-hydroxysteroid dehydrogenase.

Role in Steroid Hormone Production

Pregnenedione serves as a key intermediate in the production of several steroid hormones. These include the progestogens, glucocorticoids, mineralocorticoids, androgens, and estrogens.

Clinical Significance

Abnormal levels of pregnenedione can be indicative of certain medical conditions. For example, elevated levels of pregnenedione can be seen in congenital adrenal hyperplasia, a group of inherited disorders affecting the adrenal glands.

See Also

• Steroid hormone
• Biosynthesis
• Cholesterol
• Progesterone
• 3β-hydroxysteroid dehydrogenase
• Congenital adrenal hyperplasia

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