Periglomerular cell

Periglomerular cell is a type of interneuron that is found in the olfactory bulb. These cells are named for their location around the glomerulus in the olfactory bulb. They play a crucial role in the processing of olfactory information.

Function

Periglomerular cells are involved in the initial processing of olfactory information. They receive input from olfactory receptor neurons and provide inhibitory feedback to these neurons. This feedback helps to shape the olfactory response and may play a role in odor discrimination and identification.

Structure

Periglomerular cells are small neurons that are located in the glomerular layer of the olfactory bulb. They have a short axon that remains within the glomerulus and multiple dendrites that extend into the surrounding neuropil. The cells are typically classified based on the type of neurotransmitter they release, with the majority of periglomerular cells being either GABAergic or dopaminergic.

Clinical significance

Changes in the number or function of periglomerular cells have been implicated in a number of neurological disorders, including Parkinson's disease and schizophrenia. In addition, alterations in the olfactory system, including changes in periglomerular cells, are often an early sign of neurodegenerative diseases.

See also

• Olfactory system
• Olfactory bulb
• Interneuron
• Neuron
• Neurotransmitter

References

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