Metynodiol diacetate: Difference between revisions

Latest revision as of 06:37, 16 February 2025

Metynodiol diacetate[edit]

Metynodiol diacetate is a synthetic progestin and an estrogen used in hormonal contraception. It is a derivative of metynodiol, which is a steroid with both progestogenic and estrogenic activity. Metynodiol diacetate is primarily used in combination with other hormones in oral contraceptive pills.

Chemical Properties[edit]

Metynodiol diacetate is a steroidal compound with the chemical formula C₂₃H₃₂O₄. It is an acetate ester of metynodiol, which enhances its bioavailability and pharmacokinetics. The compound is characterized by its hydroxyl groups being acetylated, which increases its lipophilicity and allows for better absorption when administered orally.

Mechanism of Action[edit]

As a progestin, metynodiol diacetate works by binding to the progesterone receptors in the body. This action leads to changes in the endometrium that prevent implantation of a fertilized ovum. Additionally, it thickens the cervical mucus, making it more difficult for sperm to enter the uterus. The estrogenic activity of metynodiol diacetate also contributes to the suppression of ovulation by inhibiting the release of gonadotropins from the pituitary gland.

Clinical Use[edit]

Metynodiol diacetate is used in combination with other hormones in oral contraceptives. It is effective in preventing pregnancy when taken as directed. The combination of progestin and estrogen in contraceptive pills provides a dual mechanism of action, enhancing the contraceptive efficacy.

Side Effects[edit]

Common side effects of metynodiol diacetate, similar to other progestins, include nausea, headache, breast tenderness, and mood changes. Long-term use may be associated with an increased risk of thromboembolism, particularly in smokers and women over 35 years of age.

Related Pages[edit]

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-'''Metynodiol diacetate''' is a [[progestin]] medication which is used in [[hormone therapy]]. It is a derivative of [[progesterone]] and was introduced for medical use in the 1960s. Metynodiol diacetate is taken by mouth.
+{{DISPLAYTITLE:Metynodiol diacetate}}
-==Pharmacology==
+== Metynodiol diacetate ==
-Metynodiol diacetate is a progestogen, or an agonist of the [[progesterone receptor]], the biological target of progestogens like progesterone. It has weak [[androgen]]ic and [[estrogen]]ic activity and no other important hormonal activity. The medication is a prodrug of [[noretynodrel]], which is also a progestin.
-==Medical uses==
+[[File:Metynodiol_diacetate.svg|thumb|right|Chemical structure of Metynodiol diacetate]]
-Metynodiol diacetate is used as a component of menopausal hormone therapy to prevent [[endometrial hyperplasia]] and [[uterine cancer]] in women who are taking [[estrogen]]s. It is also used in the treatment of [[gynecological disorders]].
-==Side effects==
+'''Metynodiol diacetate''' is a synthetic [[progestin]] and an [[estrogen]] used in [[hormonal contraception]]. It is a derivative of [[metynodiol]], which is a [[steroid]] with both progestogenic and estrogenic activity. Metynodiol diacetate is primarily used in combination with other hormones in [[oral contraceptive]] pills.
-Side effects of metynodiol diacetate include [[menstrual irregularities]], [[nausea]], [[breast tenderness]], [[headache]], and [[acne]]. It can also cause weight gain and [[mood changes]].
-==History==
+=== Chemical Properties ===
-Metynodiol diacetate was introduced for medical use in the 1960s. It is marketed widely throughout the world.
-==Society and culture==
+Metynodiol diacetate is a [[steroid]]al compound with the chemical formula C<sub>23</sub>H<sub>32</sub>O<sub>4</sub>. It is an acetate ester of metynodiol, which enhances its [[bioavailability]] and [[pharmacokinetics]]. The compound is characterized by its [[hydroxyl]] groups being acetylated, which increases its [[lipophilicity]] and allows for better absorption when administered orally.
-Metynodiol diacetate is marketed under a variety of brand names including [[Demulen]], [[Cyclessa]], and others.
-==See also==
+=== Mechanism of Action ===
-* [[List of progestogens]]
-* [[List of progestogen esters]]
+As a progestin, metynodiol diacetate works by binding to the [[progesterone receptor]]s in the body. This action leads to changes in the [[endometrium]] that prevent [[implantation]] of a fertilized [[ovum]]. Additionally, it thickens the [[cervical mucus]], making it more difficult for [[sperm]] to enter the [[uterus]]. The estrogenic activity of metynodiol diacetate also contributes to the suppression of [[ovulation]] by inhibiting the release of [[gonadotropins]] from the [[pituitary gland]].
+=== Clinical Use ===
+Metynodiol diacetate is used in combination with other [[hormones]] in [[oral contraceptives]]. It is effective in preventing [[pregnancy]] when taken as directed. The combination of progestin and estrogen in contraceptive pills provides a dual mechanism of action, enhancing the contraceptive efficacy.
+=== Side Effects ===
+Common side effects of metynodiol diacetate, similar to other progestins, include [[nausea]], [[headache]], [[breast tenderness]], and [[mood changes]]. Long-term use may be associated with an increased risk of [[thromboembolism]], particularly in smokers and women over 35 years of age.
+== Related Pages ==
+* [[Progestin]]
+* [[Estrogen]]
+* [[Oral contraceptive]]
+* [[Steroid]]
+* [[Hormonal contraception]]
-{{Pharmacology-stub}}
 [[Category:Progestogens]]
-[[Category:Progestogen esters]]
-[[Category:Androgens and anabolic steroids]]
 [[Category:Estrogens]]
-[[Category:World Health Organization essential medicines]]
+[[Category:Contraception]]