Clocortolone pivalate: Difference between revisions

Clocortolone pivalate
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Revision as of 05:37, 16 February 2025

A topical corticosteroid used in dermatology

Clocortolone pivalate is a topical corticosteroid used in dermatology for the treatment of various skin conditions. It is known for its anti-inflammatory, antipruritic, and vasoconstrictive properties.

Pharmacology

Clocortolone pivalate is a medium-potency corticosteroid. It works by inhibiting the release of substances in the body that cause inflammation. The mechanism of action involves the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.

Clinical uses

Clocortolone pivalate is primarily used to treat inflammatory skin conditions such as eczema, psoriasis, and dermatitis. It is applied topically to the affected area, usually in the form of a cream. The medication is typically used for short-term treatment to avoid potential side effects associated with long-term corticosteroid use.

Side effects

Common side effects of clocortolone pivalate include skin irritation, dryness, and itching at the site of application. Prolonged use can lead to more serious side effects such as skin thinning, striae, and telangiectasia. Systemic absorption can occur, especially when applied to large areas or under occlusion, potentially leading to adrenal suppression.

Contraindications

Clocortolone pivalate should not be used in individuals with known hypersensitivity to corticosteroids or any component of the formulation. It is also contraindicated in patients with untreated bacterial, viral, or fungal skin infections.

Administration

The cream is typically applied to the affected area two to three times daily. It is important to use the medication as directed by a healthcare provider and to avoid using it on the face, groin, or underarms unless directed by a physician.

Related pages

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-'''Clocortolone pivalate''' is a [[topical steroid]] used in the treatment of various [[skin disorders]]. It is a medium-potency corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Clocortolone pivalate is commonly prescribed for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
+{{Short description|A topical corticosteroid used in dermatology}}
+{{Drugbox
+| verifiedfields = changed
+| verifiedrevid = 477002123
+| image = Clocortolone_pivalate.svg
+| image2 =
+| width = 200px
+| alt =
+}}
-== Pharmacology ==
+'''Clocortolone pivalate''' is a [[topical corticosteroid]] used in [[dermatology]] for the treatment of various [[skin conditions]]. It is known for its anti-inflammatory, antipruritic, and vasoconstrictive properties.
-Clocortolone pivalate functions by inducing phospholipase A2 inhibitory proteins, collectively known as lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Clocortolone pivalate's action reduces the formation, release, and activity of various chemical mediators of inflammation, including kinins, histamine, liposomal enzymes, and prostaglandin. This leads to decreased inflammation, erythema, and pruritus.
-== Indications ==
+==Pharmacology==
-Clocortolone pivalate cream is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. This includes conditions such as [[psoriasis]], [[eczema]], [[contact dermatitis]], and [[seborrheic dermatitis]]. It is suitable for use in both adults and children.
+Clocortolone pivalate is a medium-potency corticosteroid. It works by inhibiting the release of substances in the body that cause inflammation. The [[mechanism of action]] involves the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.
-== Administration and Dosage ==
+==Clinical uses==
-Clocortolone pivalate is available as a 0.1% cream. The cream should be applied to the affected area three times daily. The duration of treatment should be determined by the response of the condition to therapy. Long-term continuous therapy should be avoided where possible, particularly in children, on the face, and on intertriginous areas.
+Clocortolone pivalate is primarily used to treat [[inflammatory skin conditions]] such as [[eczema]], [[psoriasis]], and [[dermatitis]]. It is applied topically to the affected area, usually in the form of a cream. The medication is typically used for short-term treatment to avoid potential side effects associated with long-term corticosteroid use.
-== Side Effects ==
+==Side effects==
-The use of topical steroids, including clocortolone pivalate, can lead to side effects. These may include skin atrophy, striae, telangiectasias, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, and secondary infection. Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.
+Common side effects of clocortolone pivalate include [[skin irritation]], [[dryness]], and [[itching]] at the site of application. Prolonged use can lead to more serious side effects such as [[skin thinning]], [[striae]], and [[telangiectasia]]. Systemic absorption can occur, especially when applied to large areas or under occlusion, potentially leading to [[adrenal suppression]].
-== Precautions ==
+==Contraindications==
-Patients with a history of hypersensitivity to clocortolone pivalate or any of the components of the formulation should not use this medication. Caution should be exercised when topical corticosteroids are administered to a nursing woman. The safety and efficacy of drug use for longer than 2 weeks in this population have not been established.
+Clocortolone pivalate should not be used in individuals with known hypersensitivity to corticosteroids or any component of the formulation. It is also contraindicated in patients with untreated bacterial, viral, or fungal skin infections.
-== Interactions ==
+==Administration==
-There are no known significant interactions between clocortolone pivalate and other drugs. However, patients should inform their healthcare provider about all the medications they are taking, including over-the-counter drugs.
+The cream is typically applied to the affected area two to three times daily. It is important to use the medication as directed by a healthcare provider and to avoid using it on the face, groin, or underarms unless directed by a physician.
-== Conclusion ==
+==Related pages==
-Clocortolone pivalate is a valuable medication in the management of various inflammatory and pruritic skin conditions. Its efficacy, combined with a relatively favorable safety profile, makes it a suitable option for short-term treatment. However, like all medications, it should be used under the guidance of a healthcare professional to minimize potential side effects and ensure the best possible outcome for the patient.
+* [[Corticosteroid]]
+* [[Dermatology]]
+* [[Eczema]]
+* [[Psoriasis]]
+* [[Dermatitis]]
-[[Category:Dermatological preparations]]
 [[Category:Corticosteroids]]
+[[Category:Dermatologic drugs]]
-{{medicine-stub}}