Trestolone acetate: Difference between revisions

From WikiMD's Wellness Encyclopedia

CSV import
CSV import
 
Line 1: Line 1:
{{Short description|Synthetic anabolic-androgenic steroid}}
== Trestolone Acetate ==
{{Use dmy dates|date=October 2023}}


'''Trestolone acetate''', also known as '''7_-methyl-19-nortestosterone 17_-acetate''' (MENT), is a synthetic [[anabolic-androgenic steroid]] (AAS) and a derivative of [[nandrolone]]. It is primarily used in scientific research and has been investigated for potential applications in [[male contraception]] and [[hormone replacement therapy]].
[[File:Trestolone_acetate.svg|thumb|right|Chemical structure of Trestolone Acetate]]


==Chemical structure and properties==
'''Trestolone acetate''', also known as 7_-methyl-19-nortestosterone 17_-acetate (MENT acetate), is a synthetic [[androgen]] and [[anabolic steroid]] (AAS) that is used in scientific research. It is a potent [[androgen receptor]] agonist and is known for its strong anabolic effects.
Trestolone acetate is a [[nandrolone]] derivative, characterized by the presence of a methyl group at the 7_ position. This modification enhances its [[androgenic]] and [[anabolic]] activity compared to nandrolone. The acetate ester attached to the 17_-hydroxyl group prolongs its duration of action by slowing its release into the bloodstream.


==Pharmacology==
== Chemical Properties ==
Trestolone acetate acts as a potent agonist of the [[androgen receptor]] (AR), which mediates its anabolic and androgenic effects. It has been shown to have a high binding affinity for the AR, leading to significant increases in muscle mass and strength. Unlike [[testosterone]], trestolone acetate does not undergo conversion to [[dihydrotestosterone]] (DHT), which may reduce the risk of certain androgenic side effects.


==Potential applications==
Trestolone acetate is a derivative of [[nandrolone]], with a methyl group added at the 7_ position. This modification increases its [[androgenic]] and [[anabolic]] potency compared to nandrolone. The acetate ester attached to the 17_-hydroxyl group prolongs its duration of action by slowing its release into the bloodstream.
===Male contraception===
Trestolone acetate has been studied as a potential [[male contraceptive]] due to its ability to suppress [[spermatogenesis]] while maintaining [[libido]] and other androgen-dependent functions. Clinical trials have explored its efficacy in combination with other hormones, such as [[progestins]], to achieve effective contraception.


===Hormone replacement therapy===
== Mechanism of Action ==
In [[hormone replacement therapy]] for men with [[hypogonadism]], trestolone acetate may offer advantages over traditional testosterone therapy. Its potent anabolic effects and lack of conversion to DHT make it a promising candidate for maintaining muscle mass and bone density.


==Side effects==
As an androgen receptor agonist, trestolone acetate binds to the androgen receptor with high affinity. This binding initiates a cascade of events that lead to increased protein synthesis and muscle growth. It also has effects on the [[hypothalamic-pituitary-gonadal axis]], suppressing the production of endogenous [[testosterone]] and [[spermatogenesis]].
As with other AAS, trestolone acetate can cause a range of side effects, including [[acne]], [[gynecomastia]], and [[cardiovascular]] issues. Long-term use may also lead to [[liver damage]] and alterations in [[lipid profiles]].


==Legal status==
== Uses in Research ==
The legal status of trestolone acetate varies by country. In some regions, it is classified as a controlled substance, while in others, it is available for research purposes only.


==Related pages==
Trestolone acetate is primarily used in research settings to study its effects on muscle growth, [[bone density]], and its potential as a male [[contraceptive]]. Its potent anabolic effects make it a subject of interest for understanding muscle wasting conditions and other disorders related to androgen deficiency.
 
== Potential Applications ==
 
Research into trestolone acetate has explored its use as a male contraceptive due to its ability to suppress [[spermatogenesis]] while maintaining androgenic effects. It is also being studied for its potential in treating conditions such as [[hypogonadism]] and [[muscle wasting]] diseases.
 
== Side Effects ==
 
Like other anabolic steroids, trestolone acetate can cause a range of side effects. These may include [[acne]], [[gynecomastia]], [[hypertension]], and alterations in [[lipid profile]]. Long-term use can lead to [[liver damage]] and [[cardiovascular disease]].
 
== Related Pages ==
 
* [[Androgen receptor]]
* [[Anabolic steroid]]
* [[Anabolic steroid]]
* [[Nandrolone]]
* [[Nandrolone]]
* [[Testosterone]]
* [[Testosterone]]
* [[Male contraception]]
* [[Hypogonadism]]
 
==References==
{{Reflist}}


[[Category:Anabolic steroids]]
[[Category:Androgens and anabolic steroids]]
[[Category:Androgens and anabolic steroids]]
[[Category:Hormonal contraception]]
[[Category:Hormonal contraception]]
[[Category:Experimental drugs]]
[[File:Trestolone_acetate.svg|thumb|Chemical structure of trestolone acetate]]

Latest revision as of 11:11, 15 February 2025

Trestolone Acetate[edit]

Chemical structure of Trestolone Acetate

Trestolone acetate, also known as 7_-methyl-19-nortestosterone 17_-acetate (MENT acetate), is a synthetic androgen and anabolic steroid (AAS) that is used in scientific research. It is a potent androgen receptor agonist and is known for its strong anabolic effects.

Chemical Properties[edit]

Trestolone acetate is a derivative of nandrolone, with a methyl group added at the 7_ position. This modification increases its androgenic and anabolic potency compared to nandrolone. The acetate ester attached to the 17_-hydroxyl group prolongs its duration of action by slowing its release into the bloodstream.

Mechanism of Action[edit]

As an androgen receptor agonist, trestolone acetate binds to the androgen receptor with high affinity. This binding initiates a cascade of events that lead to increased protein synthesis and muscle growth. It also has effects on the hypothalamic-pituitary-gonadal axis, suppressing the production of endogenous testosterone and spermatogenesis.

Uses in Research[edit]

Trestolone acetate is primarily used in research settings to study its effects on muscle growth, bone density, and its potential as a male contraceptive. Its potent anabolic effects make it a subject of interest for understanding muscle wasting conditions and other disorders related to androgen deficiency.

Potential Applications[edit]

Research into trestolone acetate has explored its use as a male contraceptive due to its ability to suppress spermatogenesis while maintaining androgenic effects. It is also being studied for its potential in treating conditions such as hypogonadism and muscle wasting diseases.

Side Effects[edit]

Like other anabolic steroids, trestolone acetate can cause a range of side effects. These may include acne, gynecomastia, hypertension, and alterations in lipid profile. Long-term use can lead to liver damage and cardiovascular disease.

Related Pages[edit]