Piromidic acid: Difference between revisions
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== Piromidic Acid == | |||
[[File:Piromidic_acid.svg|thumb|right|Chemical structure of Piromidic Acid]] | |||
'''Piromidic acid''' is a [[pyridopyrimidine]] [[antibiotic]] that belongs to the class of [[quinolone]]s. It is primarily used in the treatment of [[urinary tract infections]] (UTIs) due to its effectiveness against a range of [[gram-negative bacteria]]. | |||
== | == Mechanism of Action == | ||
Piromidic acid works by inhibiting the [[DNA gyrase]] enzyme, which is essential for bacterial [[DNA replication]]. By preventing the supercoiling of DNA, piromidic acid disrupts the replication process, leading to bacterial cell death. This mechanism is similar to other quinolone antibiotics, which target bacterial DNA synthesis. | |||
== | == Pharmacokinetics == | ||
Piromidic acid is administered orally and is well absorbed from the [[gastrointestinal tract]]. It is distributed throughout the body and achieves high concentrations in the [[urinary tract]], making it particularly effective for treating infections in this area. The drug is metabolized in the [[liver]] and excreted primarily through the [[kidneys]]. | |||
== Clinical Uses == | |||
Piromidic acid is used to treat uncomplicated urinary tract infections caused by susceptible strains of bacteria. It is effective against common pathogens such as ''[[Escherichia coli]]'', ''[[Proteus mirabilis]]'', and ''[[Klebsiella pneumoniae]]''. However, its use is limited to specific cases due to the availability of newer quinolones with broader spectra of activity. | |||
== Side Effects == | |||
Common side effects of piromidic acid include [[gastrointestinal disturbances]] such as [[nausea]], [[vomiting]], and [[diarrhea]]. Some patients may experience [[allergic reactions]], including [[rash]] and [[pruritus]]. Rarely, it can cause [[central nervous system]] effects such as [[dizziness]] and [[headache]]. | |||
== Contraindications == | |||
Piromidic acid is contraindicated in patients with a known hypersensitivity to quinolones. It should be used with caution in patients with [[renal impairment]] due to its primary excretion through the kidneys. It is also not recommended for use in [[pregnant]] or [[breastfeeding]] women unless absolutely necessary. | |||
== Related Pages == | |||
* [[Quinolone]] | * [[Quinolone]] | ||
* [[Urinary tract infection]] | * [[Urinary tract infection]] | ||
* [[ | * [[Antibiotic]] | ||
[[Category: | [[Category:Antibiotics]] | ||
[[Category:Quinolones]] | [[Category:Quinolones]] | ||
Latest revision as of 11:01, 15 February 2025
Piromidic Acid[edit]
Piromidic acid is a pyridopyrimidine antibiotic that belongs to the class of quinolones. It is primarily used in the treatment of urinary tract infections (UTIs) due to its effectiveness against a range of gram-negative bacteria.
Mechanism of Action[edit]
Piromidic acid works by inhibiting the DNA gyrase enzyme, which is essential for bacterial DNA replication. By preventing the supercoiling of DNA, piromidic acid disrupts the replication process, leading to bacterial cell death. This mechanism is similar to other quinolone antibiotics, which target bacterial DNA synthesis.
Pharmacokinetics[edit]
Piromidic acid is administered orally and is well absorbed from the gastrointestinal tract. It is distributed throughout the body and achieves high concentrations in the urinary tract, making it particularly effective for treating infections in this area. The drug is metabolized in the liver and excreted primarily through the kidneys.
Clinical Uses[edit]
Piromidic acid is used to treat uncomplicated urinary tract infections caused by susceptible strains of bacteria. It is effective against common pathogens such as Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae. However, its use is limited to specific cases due to the availability of newer quinolones with broader spectra of activity.
Side Effects[edit]
Common side effects of piromidic acid include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. Some patients may experience allergic reactions, including rash and pruritus. Rarely, it can cause central nervous system effects such as dizziness and headache.
Contraindications[edit]
Piromidic acid is contraindicated in patients with a known hypersensitivity to quinolones. It should be used with caution in patients with renal impairment due to its primary excretion through the kidneys. It is also not recommended for use in pregnant or breastfeeding women unless absolutely necessary.
