Gemazocine: Difference between revisions

Latest revision as of 10:59, 15 February 2025

Gemazocine[edit]

Gemazocine is a synthetic opioid analgesic that belongs to the benzomorphan class of compounds. It was developed in the 1970s and is known for its potent analgesic properties. Gemazocine acts primarily as an agonist at the mu-opioid receptors, which are responsible for its pain-relieving effects.

Pharmacology[edit]

Gemazocine exhibits high affinity for the mu-opioid receptors, similar to other opioids such as morphine and fentanyl. It also has some activity at the kappa-opioid receptors, which can contribute to its analgesic effects and may influence its side effect profile.

Clinical Use[edit]

While Gemazocine was investigated for its potential use in pain management, it is not widely used in clinical practice today. The development of newer opioids with more favorable safety profiles and the potential for abuse and addiction associated with opioids have limited its use.

Side Effects[edit]

As with other opioids, Gemazocine can cause a range of side effects, including:

Mechanism of Action[edit]

Gemazocine exerts its effects by binding to and activating the mu-opioid receptors in the central nervous system. This leads to inhibition of neurotransmitter release and modulation of pain pathways, resulting in analgesia. The activation of kappa-opioid receptors may also play a role in its analgesic effects.

Synthesis[edit]

The synthesis of Gemazocine involves the chemical modification of the benzomorphan core structure. This process typically includes the introduction of specific functional groups that enhance its affinity for opioid receptors.

Related pages[edit]

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-'''Gemazocine''' is a [[benzomorphan]] derivative used in [[opioid]] research. Gemazocine is an opioid [[analgesic]] which has been used in studies on opioid receptor function and opioid analgesic drugs. It is a mixed agonist-antagonist for [[μ-opioid receptor|μ-opioid receptors]] and [[κ-opioid receptor|κ-opioid receptors]], acting as an antagonist at the former and an agonist at the latter.
+== Gemazocine ==
-==Chemistry==
+[[File:Gemazocine_structure.svg|thumb|right|Chemical structure of Gemazocine]]
-Gemazocine is a member of the [[benzomorphan]] class of opioids. It is structurally related to other benzomorphans such as [[pentazocine]], [[phenazocine]], and [[cyclazocine]], but has a unique profile of effects due to its mixed agonist-antagonist activity at different opioid receptors.
-==Pharmacology==
+'''Gemazocine''' is a synthetic opioid analgesic that belongs to the [[benzomorphan]] class of compounds. It was developed in the 1970s and is known for its potent analgesic properties. Gemazocine acts primarily as an agonist at the [[opioid receptor|mu-opioid receptors]], which are responsible for its pain-relieving effects.
-Gemazocine acts as an agonist at [[κ-opioid receptor|κ-opioid receptors]], which are involved in pain perception, stress response, and mood regulation. It also acts as an antagonist at [[μ-opioid receptor|μ-opioid receptors]], which are primarily responsible for the analgesic effects of opioids. This mixed activity gives gemazocine a unique profile of effects, which can include analgesia, dysphoria, and hallucinations.
-==Research==
+=== Pharmacology ===
-Gemazocine has been used in research to study the function of opioid receptors and the effects of various opioid analgesic drugs. It has been particularly useful in studies on the role of κ-opioid receptors in pain perception and mood regulation.
+Gemazocine exhibits high affinity for the mu-opioid receptors, similar to other opioids such as [[morphine]] and [[fentanyl]]. It also has some activity at the [[kappa-opioid receptor|kappa-opioid receptors]], which can contribute to its analgesic effects and may influence its side effect profile.
-==See also==
+=== Clinical Use ===
+While Gemazocine was investigated for its potential use in pain management, it is not widely used in clinical practice today. The development of newer opioids with more favorable safety profiles and the potential for abuse and addiction associated with opioids have limited its use.
+=== Side Effects ===
+As with other opioids, Gemazocine can cause a range of side effects, including:
+* [[Respiratory depression]]
+* [[Constipation]]
+* [[Nausea]] and [[vomiting]]
+* [[Sedation]]
+* [[Euphoria]]
+=== Mechanism of Action ===
+Gemazocine exerts its effects by binding to and activating the mu-opioid receptors in the central nervous system. This leads to inhibition of [[neurotransmitter]] release and modulation of pain pathways, resulting in analgesia. The activation of kappa-opioid receptors may also play a role in its analgesic effects.
+=== Synthesis ===
+The synthesis of Gemazocine involves the chemical modification of the benzomorphan core structure. This process typically includes the introduction of specific functional groups that enhance its affinity for opioid receptors.
+== Related pages ==
+* [[Opioid]]
+* [[Analgesic]]
 * [[Benzomorphan]]
-* [[Opioid receptor]]
+* [[Mu-opioid receptor]]
-* [[Opioid analgesic]]
 [[Category:Opioids]]
+[[Category:Analgesics]]
 [[Category:Benzomorphans]]
-[[Category:Analgesics]]
-[[Category:Research chemicals]]
-{{stub}}