Glafenine: Difference between revisions

Latest revision as of 04:06, 13 February 2025

An article about the nonsteroidal anti-inflammatory drug Glafenine

Glafenine[edit]

Glafenine is a nonsteroidal anti-inflammatory drug (NSAID) that was used for the treatment of pain and inflammation. It was introduced in the 1960s but has since been withdrawn from the market in many countries due to concerns about its safety profile, particularly its association with allergic reactions and renal failure.

Pharmacology[edit]

Glafenine works by inhibiting the cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are mediators of inflammation and pain, and by reducing their production, glafenine helps alleviate these symptoms.

Mechanism of Action[edit]

The primary mechanism of action of glafenine is the inhibition of the COX enzymes, specifically COX-1 and COX-2. This inhibition leads to a decrease in the formation of prostaglandins, which are responsible for causing inflammation, pain, and fever.

Adverse Effects[edit]

Glafenine has been associated with several adverse effects, which led to its withdrawal from the market. The most significant adverse effects include:

Allergic reactions: Glafenine can cause severe allergic reactions, including anaphylaxis, which can be life-threatening.
Renal failure: There have been reports of acute renal failure associated with the use of glafenine, particularly in patients with pre-existing kidney conditions.
Gastrointestinal issues: Like other NSAIDs, glafenine can cause gastrointestinal bleeding, ulcers, and stomach pain.

History[edit]

Glafenine was first introduced in the 1960s as a pain reliever and anti-inflammatory agent. It was marketed under various brand names and was used for the treatment of mild to moderate pain. However, due to its adverse effects, particularly the risk of severe allergic reactions, it was withdrawn from the market in many countries by the late 1980s.

Current Status[edit]

As of now, glafenine is not widely used in clinical practice due to its safety concerns. It is no longer available in many countries, and alternative NSAIDs with better safety profiles are preferred for the treatment of pain and inflammation.

Related pages[edit]

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-'''Glafenine''' is a non-steroidal anti-inflammatory drug (NSAID) that was widely used for the treatment of acute pain and rheumatic disorders. It belongs to the class of compounds known as anthranilic acid derivatives, or fenamates. Glafenine was known for its analgesic and anti-inflammatory properties, making it a popular choice for the relief of pain associated with conditions such as [[arthritis]], [[muscle pain]], and [[dysmenorrhea]]. However, its use has been discontinued in many countries due to serious adverse effects.
+{{Short description|An article about the nonsteroidal anti-inflammatory drug Glafenine}}
-== Mechanism of Action ==
+==Glafenine==
-Glafenine exerts its therapeutic effects by inhibiting the enzyme cyclooxygenase (COX), which is involved in the synthesis of prostaglandins. Prostaglandins are lipid compounds that play a key role in the inflammation process. By reducing the production of prostaglandins, glafenine helps to alleviate pain and inflammation. Its mechanism of action is similar to other NSAIDs, but it may also involve additional pharmacological targets, contributing to its analgesic efficacy.
+[[File:Glafenine.svg|thumb|right|Chemical structure of Glafenine]]
+'''Glafenine''' is a [[nonsteroidal anti-inflammatory drug]] (NSAID) that was used for the treatment of [[pain]] and [[inflammation]]. It was introduced in the 1960s but has since been withdrawn from the market in many countries due to concerns about its safety profile, particularly its association with [[allergic reactions]] and [[renal failure]].
-== Indications ==
+==Pharmacology==
-Glafenine was primarily indicated for the treatment of various forms of acute and chronic pain, including:
+Glafenine works by inhibiting the [[cyclooxygenase]] (COX) enzymes, which are involved in the synthesis of [[prostaglandins]]. Prostaglandins are mediators of inflammation and pain, and by reducing their production, glafenine helps alleviate these symptoms.
-* [[Musculoskeletal pain]]
-* [[Dysmenorrhea]]
-* Post-operative pain
-* Pain associated with [[rheumatic diseases]]
-== Adverse Effects ==
+===Mechanism of Action===
-The use of glafenine has been associated with several adverse effects, some of which can be severe. The most concerning side effect is the risk of acute renal failure, which led to its withdrawal from the market in several countries. Other adverse effects include:
+The primary mechanism of action of glafenine is the inhibition of the COX enzymes, specifically COX-1 and COX-2. This inhibition leads to a decrease in the formation of prostaglandins, which are responsible for causing inflammation, pain, and fever.
-* Gastrointestinal issues such as [[nausea]], [[vomiting]], and [[ulceration]]
-* Hypersensitivity reactions, including [[skin rash]] and [[anaphylaxis]]
-* Hepatotoxicity
-Due to these safety concerns, the use of glafenine has been largely discontinued, and it is no longer available in many parts of the world.
+==Adverse Effects==
+Glafenine has been associated with several adverse effects, which led to its withdrawal from the market. The most significant adverse effects include:
-== Pharmacokinetics ==
+* [[Allergic reactions]]: Glafenine can cause severe allergic reactions, including [[anaphylaxis]], which can be life-threatening.
-Glafenine is absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 1 to 2 hours after oral administration. It is extensively metabolized in the liver and excreted primarily in the urine. The elimination half-life of glafenine is approximately 2 to 3 hours.
+* [[Renal failure]]: There have been reports of acute renal failure associated with the use of glafenine, particularly in patients with pre-existing kidney conditions.
+* [[Gastrointestinal issues]]: Like other NSAIDs, glafenine can cause [[gastrointestinal bleeding]], [[ulcers]], and [[stomach pain]].
-== Regulatory Status ==
+==History==
-Following reports of serious adverse reactions, including cases of fatal renal failure and anaphylactic shock, regulatory authorities in several countries decided to withdraw glafenine from the market. This decision was based on the assessment that the risks associated with its use outweighed the potential benefits.
+Glafenine was first introduced in the 1960s as a pain reliever and anti-inflammatory agent. It was marketed under various brand names and was used for the treatment of mild to moderate pain. However, due to its adverse effects, particularly the risk of severe allergic reactions, it was withdrawn from the market in many countries by the late 1980s.
-== Conclusion ==
+==Current Status==
-While glafenine was once a popular analgesic and anti-inflammatory medication, its safety profile led to the discontinuation of its use. The case of glafenine underscores the importance of ongoing safety monitoring and evaluation of pharmaceuticals post-market to ensure the well-being of patients.
+As of now, glafenine is not widely used in clinical practice due to its safety concerns. It is no longer available in many countries, and alternative NSAIDs with better safety profiles are preferred for the treatment of pain and inflammation.
-[[Category:Non-steroidal anti-inflammatory drugs]]
+==Related pages==
+* [[Nonsteroidal anti-inflammatory drug]]
+* [[Cyclooxygenase]]
+* [[Prostaglandin]]
+* [[Anaphylaxis]]
+[[Category:Nonsteroidal anti-inflammatory drugs]]
 [[Category:Withdrawn drugs]]
-{{medicine-stub}}