Cefuzonam: Difference between revisions

Cefuzonam
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Revision as of 04:01, 13 February 2025

An article about the antibiotic Cefuzonam

Cefuzonam is a cephalosporin antibiotic used in the treatment of various bacterial infections. It belongs to the class of beta-lactam antibiotics and is known for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria.

Mechanism of Action

Cefuzonam works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which leads to the interruption of peptidoglycan synthesis. This results in the weakening of the cell wall and ultimately causes bacterial cell lysis and death.

Pharmacokinetics

Cefuzonam is administered via intravenous or intramuscular injection. It is well-distributed throughout the body and achieves therapeutic concentrations in various tissues and fluids. The drug is primarily excreted unchanged in the urine, making it effective for treating urinary tract infections.

Clinical Uses

Cefuzonam is indicated for the treatment of a variety of infections, including:

Side Effects

Common side effects of Cefuzonam include:

Gastrointestinal disturbances such as nausea and diarrhea
Allergic reactions, including rash and pruritus
Injection site reactions

Serious side effects are rare but may include anaphylaxis and Clostridium difficile infection.

Resistance

Bacterial resistance to Cefuzonam can occur through various mechanisms, such as the production of beta-lactamases that degrade the antibiotic, alterations in PBPs, and changes in bacterial permeability. Resistance is a growing concern and underscores the importance of appropriate antibiotic stewardship.

Related pages

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-'''Cefuzonam''' is a [[cephalosporin antibiotic]] used in the treatment of various bacterial infections. It belongs to the third generation of cephalosporins, a class of [[beta-lactam antibiotics]] that inhibit bacterial cell wall synthesis.
+{{Short description|An article about the antibiotic Cefuzonam}}
+{{Drugbox
+| verifiedfields = changed
+| verifiedrevid = 123456789
+| image = Cefuzonam.svg
+| image_size = 200px
+| image_alt = Chemical structure of Cefuzonam
+}}
-== Mechanism of Action ==
+'''Cefuzonam''' is a [[cephalosporin]] [[antibiotic]] used in the treatment of various bacterial infections. It belongs to the class of beta-lactam antibiotics and is known for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria.
-Cefuzonam, like other cephalosporins, works by inhibiting the synthesis of the bacterial cell wall. It binds to specific [[penicillin-binding proteins]] (PBPs) located inside the bacterial cell wall. This binding leads to the inhibition of the third and last stage of bacterial cell wall synthesis, which is ultimately lethal to the bacteria.
-== Medical Uses ==
+==Mechanism of Action==
-Cefuzonam is used to treat a variety of bacterial infections, including those caused by [[Gram-positive bacteria]] and [[Gram-negative bacteria]]. It is particularly effective against infections caused by [[Escherichia coli]], [[Klebsiella pneumoniae]], and [[Proteus mirabilis]].
+Cefuzonam works by inhibiting bacterial [[cell wall]] synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which leads to the interruption of peptidoglycan synthesis. This results in the weakening of the cell wall and ultimately causes bacterial cell lysis and death.
-== Side Effects ==
+==Pharmacokinetics==
-Common side effects of cefuzonam include nausea, vomiting, diarrhea, and allergic reactions. In rare cases, it can cause serious side effects such as [[Clostridium difficile-associated diarrhea]] (CDAD), [[Stevens-Johnson syndrome]], and [[anaphylaxis]].
+Cefuzonam is administered via [[intravenous]] or [[intramuscular]] injection. It is well-distributed throughout the body and achieves therapeutic concentrations in various tissues and fluids. The drug is primarily excreted unchanged in the [[urine]], making it effective for treating urinary tract infections.
-== Drug Interactions ==
+==Clinical Uses==
-Cefuzonam may interact with other drugs, particularly those that are nephrotoxic or that alter kidney function. These include [[aminoglycosides]], [[diuretics]], and [[nonsteroidal anti-inflammatory drugs]] (NSAIDs).
+Cefuzonam is indicated for the treatment of a variety of infections, including:
+* [[Respiratory tract infections]]
+* [[Urinary tract infections]]
+* [[Skin and soft tissue infections]]
+* [[Intra-abdominal infections]]
-== See Also ==
+==Side Effects==
+Common side effects of Cefuzonam include:
+* [[Gastrointestinal disturbances]] such as nausea and diarrhea
+* [[Allergic reactions]], including rash and pruritus
+* [[Injection site reactions]]
+Serious side effects are rare but may include [[anaphylaxis]] and [[Clostridium difficile infection]].
+==Resistance==
+Bacterial resistance to Cefuzonam can occur through various mechanisms, such as the production of beta-lactamases that degrade the antibiotic, alterations in PBPs, and changes in bacterial permeability. Resistance is a growing concern and underscores the importance of appropriate antibiotic stewardship.
+==Related pages==
 * [[Cephalosporin]]
-* [[Beta-lactam antibiotics]]
+* [[Antibiotic resistance]]
-* [[Penicillin-binding proteins]]
+* [[Beta-lactam antibiotic]]
-* [[Gram-positive bacteria]]
-* [[Gram-negative bacteria]]
-* [[Escherichia coli]]
-* [[Klebsiella pneumoniae]]
-* [[Proteus mirabilis]]
-* [[Clostridium difficile-associated diarrhea]]
-* [[Stevens-Johnson syndrome]]
-* [[Anaphylaxis]]
-* [[Aminoglycosides]]
-* [[Diuretics]]
-* [[Nonsteroidal anti-inflammatory drugs]]
-[[Category:Antibiotics]]
+[[Category:Cephalosporin antibiotics]]
-[[Category:Cephalosporins]]
 [[Category:Beta-lactam antibiotics]]
-{{medicine-stub}}