DPDPE: Difference between revisions
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{{DISPLAYTITLE:DPDPE}} | |||
== | == Overview == | ||
'''DPDPE''' is a synthetic [[opioid]] peptide that acts as a selective [[delta-opioid receptor]] agonist. It is primarily used in research to study the function and pharmacology of delta-opioid receptors, which are one of the three main types of opioid receptors, the others being [[mu-opioid receptor|mu]] and [[kappa-opioid receptor|kappa]]. | |||
== Chemical Structure == | |||
[[File:DPDPE_structure.svg|thumb|right|Chemical structure of DPDPE]] | |||
DPDPE stands for [[D-Pen2, D-Pen5]]-enkephalin, which indicates that it is a modified form of the naturally occurring [[enkephalin]] peptides. The structure of DPDPE includes two D-penicillamine residues, which contribute to its high selectivity and affinity for delta-opioid receptors. | |||
== Mechanism of Action == | |||
DPDPE binds to the delta-opioid receptors, which are [[G protein-coupled receptor|G protein-coupled receptors]] located primarily in the [[central nervous system]] and [[peripheral nervous system]]. Upon binding, DPDPE activates these receptors, leading to a cascade of intracellular events that result in analgesic effects, among other physiological responses. | |||
== | == Pharmacological Effects == | ||
The activation of delta-opioid receptors by DPDPE can produce analgesia, although it is generally less potent than the analgesia produced by mu-opioid receptor agonists. Delta-opioid receptor activation has also been associated with mood modulation and potential antidepressant effects. However, the precise role of delta-opioid receptors in these processes is still under investigation. | |||
DPDPE is used in | == Research Applications == | ||
DPDPE is widely used in [[pharmacology]] and [[neuroscience]] research to explore the role of delta-opioid receptors in pain modulation, mood regulation, and other physiological processes. It serves as a valuable tool for understanding the distinct functions of different opioid receptor subtypes. | |||
== | == Safety and Toxicity == | ||
As a research chemical, DPDPE is not intended for human or veterinary use. Its safety profile in humans is not well-established, and it should be handled with caution in laboratory settings. | |||
As | |||
== Related Pages == | |||
* [[Opioid receptor]] | * [[Opioid receptor]] | ||
* [[ | * [[Delta-opioid receptor]] | ||
* [[ | * [[Enkephalin]] | ||
* [[G protein-coupled receptor]] | |||
[[ | |||
[[Category:Opioid peptides]] | |||
[[Category:Pharmacology]] | |||
Latest revision as of 03:49, 13 February 2025
Overview[edit]
DPDPE is a synthetic opioid peptide that acts as a selective delta-opioid receptor agonist. It is primarily used in research to study the function and pharmacology of delta-opioid receptors, which are one of the three main types of opioid receptors, the others being mu and kappa.
Chemical Structure[edit]
DPDPE stands for D-Pen2, D-Pen5-enkephalin, which indicates that it is a modified form of the naturally occurring enkephalin peptides. The structure of DPDPE includes two D-penicillamine residues, which contribute to its high selectivity and affinity for delta-opioid receptors.
Mechanism of Action[edit]
DPDPE binds to the delta-opioid receptors, which are G protein-coupled receptors located primarily in the central nervous system and peripheral nervous system. Upon binding, DPDPE activates these receptors, leading to a cascade of intracellular events that result in analgesic effects, among other physiological responses.
Pharmacological Effects[edit]
The activation of delta-opioid receptors by DPDPE can produce analgesia, although it is generally less potent than the analgesia produced by mu-opioid receptor agonists. Delta-opioid receptor activation has also been associated with mood modulation and potential antidepressant effects. However, the precise role of delta-opioid receptors in these processes is still under investigation.
Research Applications[edit]
DPDPE is widely used in pharmacology and neuroscience research to explore the role of delta-opioid receptors in pain modulation, mood regulation, and other physiological processes. It serves as a valuable tool for understanding the distinct functions of different opioid receptor subtypes.
Safety and Toxicity[edit]
As a research chemical, DPDPE is not intended for human or veterinary use. Its safety profile in humans is not well-established, and it should be handled with caution in laboratory settings.
