Eoxin: Difference between revisions
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== Eoxin == | |||
[[File:Eoxin_A4.svg|thumb|right|Structure of Eoxin A4]] | |||
'''Eoxins''' are a group of [[bioactive]] [[lipid mediators]] derived from [[arachidonic acid]] through the [[lipoxygenase]] pathway. They are part of the [[eicosanoid]] family, which includes other important molecules such as [[prostaglandins]], [[thromboxanes]], and [[leukotrienes]]. Eoxins are primarily produced by [[eosinophils]], [[mast cells]], and certain types of [[tumor cells]]. | |||
Eoxins are | |||
== | == Biosynthesis == | ||
== | Eoxins are synthesized from [[arachidonic acid]] by the action of the [[enzyme]] [[15-lipoxygenase]] (15-LOX). The initial step involves the conversion of arachidonic acid to 15-hydroperoxyeicosatetraenoic acid (15-HPETE), which is then further metabolized to produce various eoxins, including Eoxin A4, Eoxin C4, Eoxin D4, and Eoxin E4. | ||
* [[ | == Biological Functions == | ||
Eoxins play a significant role in [[inflammation]] and are involved in the pathophysiology of several [[allergic]] and [[inflammatory diseases]]. They are known to contribute to the recruitment and activation of [[eosinophils]] and other [[immune cells]] at sites of inflammation. Eoxins have been implicated in conditions such as [[asthma]], [[allergic rhinitis]], and certain types of [[cancer]]. | |||
== Clinical Significance == | |||
Due to their role in inflammatory processes, eoxins are considered potential targets for therapeutic intervention in diseases characterized by [[eosinophilic inflammation]]. Research is ongoing to develop [[inhibitors]] that can block the synthesis or action of eoxins, which may provide new treatment options for patients with [[asthma]] and other related conditions. | |||
== Related Pages == | |||
* [[Eicosanoid]] | |||
* [[Arachidonic acid]] | * [[Arachidonic acid]] | ||
* [[Lipoxygenase]] | * [[Lipoxygenase]] | ||
* [[Eosinophil]] | * [[Eosinophil]] | ||
* [[Inflammation]] | |||
[[Category:Eicosanoids]] | |||
[[Category: | |||
[[Category:Inflammation]] | [[Category:Inflammation]] | ||
Latest revision as of 03:40, 13 February 2025
Eoxin[edit]
Eoxins are a group of bioactive lipid mediators derived from arachidonic acid through the lipoxygenase pathway. They are part of the eicosanoid family, which includes other important molecules such as prostaglandins, thromboxanes, and leukotrienes. Eoxins are primarily produced by eosinophils, mast cells, and certain types of tumor cells.
Biosynthesis[edit]
Eoxins are synthesized from arachidonic acid by the action of the enzyme 15-lipoxygenase (15-LOX). The initial step involves the conversion of arachidonic acid to 15-hydroperoxyeicosatetraenoic acid (15-HPETE), which is then further metabolized to produce various eoxins, including Eoxin A4, Eoxin C4, Eoxin D4, and Eoxin E4.
Biological Functions[edit]
Eoxins play a significant role in inflammation and are involved in the pathophysiology of several allergic and inflammatory diseases. They are known to contribute to the recruitment and activation of eosinophils and other immune cells at sites of inflammation. Eoxins have been implicated in conditions such as asthma, allergic rhinitis, and certain types of cancer.
Clinical Significance[edit]
Due to their role in inflammatory processes, eoxins are considered potential targets for therapeutic intervention in diseases characterized by eosinophilic inflammation. Research is ongoing to develop inhibitors that can block the synthesis or action of eoxins, which may provide new treatment options for patients with asthma and other related conditions.
