Oxaprozin: Difference between revisions

Latest revision as of 03:37, 13 February 2025

Oxaprozin[edit]

Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions such as arthritis. It is part of the propionic acid class of NSAIDs, which also includes drugs like ibuprofen and naproxen.

Pharmacology[edit]

Oxaprozin works by inhibiting the cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are mediators of inflammation and pain, and by reducing their production, oxaprozin helps alleviate these symptoms.

Mechanism of Action[edit]

The primary mechanism of action of oxaprozin is the inhibition of the COX-1 and COX-2 enzymes. This inhibition leads to a decrease in the formation of prostaglandins, which are compounds that contribute to inflammation, pain, and fever.

Pharmacokinetics[edit]

Oxaprozin is well absorbed from the gastrointestinal tract after oral administration. It has a long half-life, which allows for once-daily dosing. The drug is extensively metabolized in the liver and excreted in the urine.

Clinical Uses[edit]

Oxaprozin is primarily used for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It helps reduce joint pain, swelling, and stiffness, improving the quality of life for patients with these chronic conditions.

Side Effects[edit]

Common side effects of oxaprozin include gastrointestinal issues such as nausea, vomiting, diarrhea, and dyspepsia. Like other NSAIDs, it can also increase the risk of gastrointestinal bleeding, ulcers, and renal impairment.

Contraindications[edit]

Oxaprozin should not be used in individuals with known hypersensitivity to the drug or other NSAIDs. It is also contraindicated in patients with a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.

Related pages[edit]

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-{{intro}}
+== Oxaprozin ==
-Oxaprozin is a long acting nonsteroidal antiinflammatory drug (NSAID) available by prescription only which is used for therapy of chronic arthritis.
-{{livtox}}
+[[File:Oxaprozin.svg|thumb|right|Chemical structure of Oxaprozin]]
-Oxaprozin has been linked to rare instances of idiosyncratic drug induced liver disease.
-{{moa}}
+'''Oxaprozin''' is a nonsteroidal anti-inflammatory drug ([[NSAID]]) used to relieve pain and inflammation in conditions such as [[arthritis]]. It is part of the propionic acid class of NSAIDs, which also includes drugs like [[ibuprofen]] and [[naproxen]].
-Oxaprozin (ox" a proe' zin) belongs to the propionic acid derivative class of NSAIDs similar to naproxen and ibuprofen.  Like other NSAIDs, oxaprozin is a potent cyclo-oxygenase (Cox-1 and -2) inhibitor which leads to decrease in synthesis of proinflammatory prostaglandins, which are potent mediators of pain and inflammatory pathways.  Oxaprozin has analgesic as well as antipyretic and antiinflammatory activities.  Because of its long half-life, oxaprozin can be given once daily.
-{{fda}}
+== Pharmacology ==
-Oxaprozin was approved in the United States in 1992 and is still widely used.  Oxaprozin is indicated for the treatment of chronic arthritis due to osteoarthritis, rheumatoid arthritis and juvenile rheumatoid arthritis.  Oxaprozin is available in tablets of 600 mg in several generic forms and under the brand name Daypro.
-{{dose}}
+Oxaprozin works by inhibiting the [[cyclooxygenase]] (COX) enzymes, which are involved in the synthesis of [[prostaglandins]]. Prostaglandins are mediators of inflammation and pain, and by reducing their production, oxaprozin helps alleviate these symptoms.
-The recommended dose in adults is 600 to 1200 mg once daily.
-{{se}}
+=== Mechanism of Action ===
-Oxaprozin is generally well tolerated, but side effects can include [[headache]], [[dizziness]], [[somnolence]], [[gastrointestinal upset]], [[nausea]], [[abdominal discomfort]], [[diarrhea]], [[peripheral edema]] and [[hypersensitivity reactions]].
-{{nsaids}}
+The primary mechanism of action of oxaprozin is the inhibition of the COX-1 and COX-2 enzymes. This inhibition leads to a decrease in the formation of prostaglandins, which are compounds that contribute to inflammation, pain, and fever.
-{{coststubd}}
+=== Pharmacokinetics ===
+Oxaprozin is well absorbed from the gastrointestinal tract after oral administration. It has a long half-life, which allows for once-daily dosing. The drug is extensively metabolized in the liver and excreted in the urine.
+== Clinical Uses ==
+Oxaprozin is primarily used for the treatment of [[rheumatoid arthritis]], [[osteoarthritis]], and [[ankylosing spondylitis]]. It helps reduce joint pain, swelling, and stiffness, improving the quality of life for patients with these chronic conditions.
+== Side Effects ==
+Common side effects of oxaprozin include gastrointestinal issues such as [[nausea]], [[vomiting]], [[diarrhea]], and [[dyspepsia]]. Like other NSAIDs, it can also increase the risk of [[gastrointestinal bleeding]], [[ulcers]], and [[renal impairment]].
+== Contraindications ==
+Oxaprozin should not be used in individuals with known hypersensitivity to the drug or other NSAIDs. It is also contraindicated in patients with a history of [[asthma]], [[urticaria]], or other allergic-type reactions after taking aspirin or other NSAIDs.
+== Related pages ==
+* [[Nonsteroidal anti-inflammatory drug]]
+* [[Rheumatoid arthritis]]
+* [[Osteoarthritis]]
+* [[Ankylosing spondylitis]]
+[[Category:Nonsteroidal anti-inflammatory drugs]]