Dazopride: Difference between revisions
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'''Dazopride''' is a [[drug]] that | {{Short description|Overview of the drug Dazopride}} | ||
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'''Dazopride''' is a [[pharmaceutical drug]] that acts as a [[gastroprokinetic agent]] and [[antiemetic]]. It is primarily used in the treatment of [[gastrointestinal disorders]] and to prevent [[nausea]] and [[vomiting]]. | |||
==Pharmacology== | ==Pharmacology== | ||
Dazopride | Dazopride functions by enhancing the motility of the [[gastrointestinal tract]]. It achieves this by acting as a [[serotonin receptor]] agonist, specifically targeting the [[5-HT4 receptor|5-HT4]] subtype. This action facilitates the release of [[acetylcholine]] in the [[enteric nervous system]], which in turn stimulates [[peristalsis]]. | ||
[[File:Dazopride.svg|thumb|left|Structural formula of Dazopride]] | |||
In addition to its prokinetic effects, Dazopride also exhibits antiemetic properties. It is believed to exert these effects through antagonism of the [[5-HT3 receptor|5-HT3]] receptors, which are involved in the emetic response. | |||
==Clinical | ==Clinical Uses== | ||
Dazopride | Dazopride is used in the management of conditions such as [[gastroparesis]], where delayed gastric emptying causes symptoms like [[bloating]], [[nausea]], and [[vomiting]]. It is also employed in the prevention of [[postoperative nausea and vomiting]] (PONV) and [[chemotherapy-induced nausea and vomiting]] (CINV). | ||
==Side | ==Side Effects== | ||
Common side effects of Dazopride include [[headache]], [[dizziness]], and [[diarrhea]]. In some cases, patients may experience [[abdominal pain]] or [[cramping]]. As with any medication, there is a risk of [[allergic reactions]], which can manifest as [[rash]], [[itching]], or [[swelling]]. | |||
== | ==Mechanism of Action== | ||
Dazopride's dual mechanism of action involves both agonistic and antagonistic effects on serotonin receptors. By stimulating the 5-HT4 receptors, it enhances [[gastrointestinal motility]], while its antagonistic action on 5-HT3 receptors helps to mitigate nausea and vomiting. | |||
[[ | ==Related pages== | ||
[[ | * [[Gastroprokinetic agent]] | ||
[[ | * [[Antiemetic]] | ||
* [[Serotonin receptor]] | |||
* [[Gastroparesis]] | |||
[[Category:Prokinetic agents]] | |||
[[Category:Antiemetics]] | |||
Latest revision as of 03:33, 13 February 2025
Overview of the drug Dazopride
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Dazopride is a pharmaceutical drug that acts as a gastroprokinetic agent and antiemetic. It is primarily used in the treatment of gastrointestinal disorders and to prevent nausea and vomiting.
Pharmacology[edit]
Dazopride functions by enhancing the motility of the gastrointestinal tract. It achieves this by acting as a serotonin receptor agonist, specifically targeting the 5-HT4 subtype. This action facilitates the release of acetylcholine in the enteric nervous system, which in turn stimulates peristalsis.
In addition to its prokinetic effects, Dazopride also exhibits antiemetic properties. It is believed to exert these effects through antagonism of the 5-HT3 receptors, which are involved in the emetic response.
Clinical Uses[edit]
Dazopride is used in the management of conditions such as gastroparesis, where delayed gastric emptying causes symptoms like bloating, nausea, and vomiting. It is also employed in the prevention of postoperative nausea and vomiting (PONV) and chemotherapy-induced nausea and vomiting (CINV).
Side Effects[edit]
Common side effects of Dazopride include headache, dizziness, and diarrhea. In some cases, patients may experience abdominal pain or cramping. As with any medication, there is a risk of allergic reactions, which can manifest as rash, itching, or swelling.
Mechanism of Action[edit]
Dazopride's dual mechanism of action involves both agonistic and antagonistic effects on serotonin receptors. By stimulating the 5-HT4 receptors, it enhances gastrointestinal motility, while its antagonistic action on 5-HT3 receptors helps to mitigate nausea and vomiting.
