Ceronapril: Difference between revisions
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{{Short description|Overview of the drug Ceronapril}} | |||
{{Drugbox}} | |||
== | ==Overview== | ||
Ceronapril | '''Ceronapril''' is a pharmaceutical drug that belongs to the class of [[angiotensin-converting enzyme inhibitors]] (ACE inhibitors). It is primarily used in the treatment of [[hypertension]] and [[congestive heart failure]]. Ceronapril works by inhibiting the conversion of [[angiotensin I]] to [[angiotensin II]], a potent vasoconstrictor, thereby reducing blood pressure and decreasing the workload on the heart. | ||
==Clinical | ==Mechanism of Action== | ||
Ceronapril is | Ceronapril inhibits the [[angiotensin-converting enzyme]] (ACE), which is responsible for the conversion of angiotensin I to angiotensin II. Angiotensin II is a hormone that causes blood vessels to constrict, leading to increased blood pressure. By blocking this conversion, Ceronapril causes vasodilation, which lowers blood pressure and improves blood flow. | ||
==Pharmacokinetics== | |||
Ceronapril is administered orally and is absorbed through the gastrointestinal tract. It is metabolized in the liver and excreted primarily through the kidneys. The drug has a half-life that allows for once-daily dosing, making it convenient for patients to use. | |||
==Clinical Uses== | |||
Ceronapril is indicated for the treatment of: | |||
* [[Hypertension]]: By lowering blood pressure, Ceronapril helps prevent complications such as [[stroke]], [[myocardial infarction]], and [[kidney failure]]. | |||
* [[Congestive heart failure]]: It reduces the symptoms of heart failure by decreasing the workload on the heart and improving cardiac output. | |||
==Side Effects== | ==Side Effects== | ||
Common side effects of Ceronapril include: | |||
* [[Cough]] | |||
* [[Hyperkalemia]] | |||
* [[Dizziness]] | |||
* [[Fatigue]] | |||
Less common but serious side effects may include: | |||
* [[Angioedema]] | |||
* [[Renal impairment]] | |||
== | ==Contraindications== | ||
Ceronapril is contraindicated in patients with: | |||
* [[History of angioedema]] related to previous ACE inhibitor therapy | |||
* [[Pregnancy]]: Due to the risk of fetal toxicity | |||
* [[Severe renal impairment]] | |||
==Interactions== | ==Interactions== | ||
Ceronapril may interact with other medications, including [[ | Ceronapril may interact with other medications, including: | ||
* [[Diuretics]]: May enhance the hypotensive effect | |||
* [[Potassium supplements]] or [[potassium-sparing diuretics]]: May increase the risk of hyperkalemia | |||
* [[Nonsteroidal anti-inflammatory drugs]] (NSAIDs): May reduce the antihypertensive effect | |||
==Image== | |||
[[File:Ceronapril.svg|thumb|right|Chemical structure of Ceronapril]] | |||
== | ==Related pages== | ||
* [[ | * [[ACE inhibitors]] | ||
* [[Hypertension]] | * [[Hypertension]] | ||
* [[ | * [[Congestive heart failure]] | ||
[[Category:ACE inhibitors]] | [[Category:ACE inhibitors]] | ||
[[Category: | [[Category:Antihypertensive agents]] | ||
Latest revision as of 03:32, 13 February 2025
Overview of the drug Ceronapril
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Overview[edit]
Ceronapril is a pharmaceutical drug that belongs to the class of angiotensin-converting enzyme inhibitors (ACE inhibitors). It is primarily used in the treatment of hypertension and congestive heart failure. Ceronapril works by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby reducing blood pressure and decreasing the workload on the heart.
Mechanism of Action[edit]
Ceronapril inhibits the angiotensin-converting enzyme (ACE), which is responsible for the conversion of angiotensin I to angiotensin II. Angiotensin II is a hormone that causes blood vessels to constrict, leading to increased blood pressure. By blocking this conversion, Ceronapril causes vasodilation, which lowers blood pressure and improves blood flow.
Pharmacokinetics[edit]
Ceronapril is administered orally and is absorbed through the gastrointestinal tract. It is metabolized in the liver and excreted primarily through the kidneys. The drug has a half-life that allows for once-daily dosing, making it convenient for patients to use.
Clinical Uses[edit]
Ceronapril is indicated for the treatment of:
- Hypertension: By lowering blood pressure, Ceronapril helps prevent complications such as stroke, myocardial infarction, and kidney failure.
- Congestive heart failure: It reduces the symptoms of heart failure by decreasing the workload on the heart and improving cardiac output.
Side Effects[edit]
Common side effects of Ceronapril include:
Less common but serious side effects may include:
Contraindications[edit]
Ceronapril is contraindicated in patients with:
- History of angioedema related to previous ACE inhibitor therapy
- Pregnancy: Due to the risk of fetal toxicity
- Severe renal impairment
Interactions[edit]
Ceronapril may interact with other medications, including:
- Diuretics: May enhance the hypotensive effect
- Potassium supplements or potassium-sparing diuretics: May increase the risk of hyperkalemia
- Nonsteroidal anti-inflammatory drugs (NSAIDs): May reduce the antihypertensive effect
Image[edit]
