Glisoxepide: Difference between revisions
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{{Short description|An oral antidiabetic drug}} | |||
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'''Glisoxepide''' is an oral [[antidiabetic drug]] belonging to the class of [[sulfonylureas]]. It is used in the management of [[type 2 diabetes mellitus]] to help control blood sugar levels. | |||
Glisoxepide | ==Mechanism of Action== | ||
Glisoxepide works by stimulating the [[pancreas]] to release more [[insulin]]. It binds to the sulfonylurea receptor on the [[beta cells]] of the pancreas, leading to the closure of [[ATP-sensitive potassium channels]]. This results in the depolarization of the cell membrane and the opening of [[voltage-gated calcium channels]], allowing calcium influx and subsequent insulin release. | |||
== | ==Pharmacokinetics== | ||
Glisoxepide is absorbed from the [[gastrointestinal tract]] and undergoes hepatic metabolism. It has a relatively long half-life, which allows for once-daily dosing. The drug and its metabolites are excreted primarily via the [[kidneys]]. | |||
==Clinical Use== | |||
Glisoxepide is indicated for the treatment of [[type 2 diabetes mellitus]] in patients who cannot achieve adequate glycemic control with [[diet]] and [[exercise]] alone. It may be used as monotherapy or in combination with other antidiabetic agents such as [[metformin]] or [[insulin]]. | |||
== | ==Side Effects== | ||
Common side effects of glisoxepide include [[hypoglycemia]], [[weight gain]], and [[gastrointestinal disturbances]] such as [[nausea]] and [[diarrhea]]. Rarely, it may cause [[allergic reactions]] or [[hematological disorders]] such as [[leukopenia]] or [[thrombocytopenia]]. | |||
Glisoxepide | ==Contraindications== | ||
Glisoxepide is contraindicated in patients with [[type 1 diabetes mellitus]], [[diabetic ketoacidosis]], or severe [[renal]] or [[hepatic impairment]]. It should be used with caution in patients with [[cardiovascular disease]]. | |||
==Related pages== | |||
* [[Sulfonylurea]] | * [[Sulfonylurea]] | ||
* [[Type 2 diabetes]] | * [[Type 2 diabetes mellitus]] | ||
* [[Insulin]] | * [[Insulin]] | ||
* [[ | * [[Metformin]] | ||
[[Category:Sulfonylureas]] | |||
[[Category:Antidiabetic drugs]] | [[Category:Antidiabetic drugs]] | ||
Latest revision as of 03:32, 13 February 2025
An oral antidiabetic drug
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Glisoxepide is an oral antidiabetic drug belonging to the class of sulfonylureas. It is used in the management of type 2 diabetes mellitus to help control blood sugar levels.
Mechanism of Action[edit]
Glisoxepide works by stimulating the pancreas to release more insulin. It binds to the sulfonylurea receptor on the beta cells of the pancreas, leading to the closure of ATP-sensitive potassium channels. This results in the depolarization of the cell membrane and the opening of voltage-gated calcium channels, allowing calcium influx and subsequent insulin release.
Pharmacokinetics[edit]
Glisoxepide is absorbed from the gastrointestinal tract and undergoes hepatic metabolism. It has a relatively long half-life, which allows for once-daily dosing. The drug and its metabolites are excreted primarily via the kidneys.
Clinical Use[edit]
Glisoxepide is indicated for the treatment of type 2 diabetes mellitus in patients who cannot achieve adequate glycemic control with diet and exercise alone. It may be used as monotherapy or in combination with other antidiabetic agents such as metformin or insulin.
Side Effects[edit]
Common side effects of glisoxepide include hypoglycemia, weight gain, and gastrointestinal disturbances such as nausea and diarrhea. Rarely, it may cause allergic reactions or hematological disorders such as leukopenia or thrombocytopenia.
Contraindications[edit]
Glisoxepide is contraindicated in patients with type 1 diabetes mellitus, diabetic ketoacidosis, or severe renal or hepatic impairment. It should be used with caution in patients with cardiovascular disease.
