JWH-120: Difference between revisions
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{{DISPLAYTITLE:JWH-120}} | |||
== | == Overview == | ||
JWH-120 is part of the [[naphthoylindole]] family of | '''JWH-120''' is a synthetic [[cannabinoid]] that acts as a potent agonist at the [[cannabinoid receptor]]s. It is part of the [[naphthoylindole]] family of compounds, which are known for their ability to mimic the effects of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]]. | ||
== | == Chemical Structure == | ||
JWH-120 | [[File:JWH-120.png|thumb|right|Chemical structure of JWH-120]] | ||
JWH-120 is characterized by its naphthoylindole structure, which includes a naphthalene ring linked to an indole moiety. This structure is crucial for its binding affinity to cannabinoid receptors, particularly [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] receptors. | |||
== | == Pharmacology == | ||
JWH-120 functions as a full agonist at both CB1 and CB2 receptors, with a higher affinity for the CB2 receptor. This selectivity makes it of interest in research focused on the [[immune system]] and [[inflammation]], as CB2 receptors are primarily located in peripheral tissues and immune cells. | |||
== | === Mechanism of Action === | ||
Upon binding to cannabinoid receptors, JWH-120 activates the [[G-protein coupled receptor]] pathways, leading to the inhibition of [[adenylate cyclase]] and a decrease in [[cyclic AMP]] levels. This results in various downstream effects, including modulation of [[neurotransmitter]] release and [[immune response]]. | |||
== | == Potential Applications == | ||
Research into JWH-120 and similar compounds is ongoing, with potential applications in the treatment of [[pain]], [[inflammation]], and [[neurological disorders]]. However, due to its synthetic nature and potential for abuse, it is also a subject of regulatory scrutiny. | |||
== Legal Status == | |||
The legal status of JWH-120 varies by country. In many jurisdictions, it is classified as a controlled substance due to its psychoactive properties and potential for abuse. Researchers must comply with local regulations when studying this compound. | |||
== Safety and Toxicity == | |||
The safety profile of JWH-120 is not well-established, and its use outside of controlled research settings is not recommended. Potential side effects may include [[tachycardia]], [[anxiety]], and [[hallucinations]], similar to other synthetic cannabinoids. | |||
== Related Pages == | |||
* [[Cannabinoid receptor]] | * [[Cannabinoid receptor]] | ||
* [[ | * [[Synthetic cannabinoid]] | ||
* [[JWH series]] | |||
* [[CB1 receptor]] | |||
* [[CB2 receptor]] | |||
[[Category:Synthetic cannabinoids]] | [[Category:Synthetic cannabinoids]] | ||
[[Category: | [[Category:Research chemicals]] | ||
Latest revision as of 03:28, 13 February 2025
Overview[edit]
JWH-120 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their ability to mimic the effects of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.
Chemical Structure[edit]
JWH-120 is characterized by its naphthoylindole structure, which includes a naphthalene ring linked to an indole moiety. This structure is crucial for its binding affinity to cannabinoid receptors, particularly CB1 and CB2 receptors.
Pharmacology[edit]
JWH-120 functions as a full agonist at both CB1 and CB2 receptors, with a higher affinity for the CB2 receptor. This selectivity makes it of interest in research focused on the immune system and inflammation, as CB2 receptors are primarily located in peripheral tissues and immune cells.
Mechanism of Action[edit]
Upon binding to cannabinoid receptors, JWH-120 activates the G-protein coupled receptor pathways, leading to the inhibition of adenylate cyclase and a decrease in cyclic AMP levels. This results in various downstream effects, including modulation of neurotransmitter release and immune response.
Potential Applications[edit]
Research into JWH-120 and similar compounds is ongoing, with potential applications in the treatment of pain, inflammation, and neurological disorders. However, due to its synthetic nature and potential for abuse, it is also a subject of regulatory scrutiny.
Legal Status[edit]
The legal status of JWH-120 varies by country. In many jurisdictions, it is classified as a controlled substance due to its psychoactive properties and potential for abuse. Researchers must comply with local regulations when studying this compound.
Safety and Toxicity[edit]
The safety profile of JWH-120 is not well-established, and its use outside of controlled research settings is not recommended. Potential side effects may include tachycardia, anxiety, and hallucinations, similar to other synthetic cannabinoids.
