ECPLA: Difference between revisions

From WikiMD's Wellness Encyclopedia

CSV import
Tags: mobile edit mobile web edit
 
CSV import
 
Line 1: Line 1:
'''ECPLA''' (Eicosapentaenoic Acid Catabolic Pathway Activator) is a [[protein]] that in humans is encoded by the ECPLA [[gene]]. This protein is involved in the catabolic pathway of [[eicosapentaenoic acid]] (EPA), a type of [[omega-3 fatty acid]].
{{DISPLAYTITLE:Extracorporeal Membrane Oxygenation (ECMO)}}


== Function ==
== Overview ==
[[File:ECPLA.svg|thumb|right|Diagram of ECMO circuit]]
Extracorporeal Membrane Oxygenation (ECMO) is a form of [[extracorporeal life support]] used in patients with severe and life-threatening illness that prevents the heart and lungs from functioning properly. ECMO provides prolonged cardiac and respiratory support by removing blood from the body, oxygenating it, and then returning it to the patient.


The ECPLA protein is an activator of the catabolic pathway of eicosapentaenoic acid (EPA). EPA is an omega-3 fatty acid that is a precursor to the [[prostaglandin]]-3 (PG-3) series, [[leukotriene]]-5 series, and [[thromboxane]]-3 series. These molecules play a crucial role in [[inflammation]], [[blood clotting]], and [[vasoconstriction]]. By activating the catabolic pathway of EPA, ECPLA helps to regulate these processes.
== History ==
The development of ECMO began in the 1950s with the advent of the [[heart-lung machine]], which was used during [[cardiac surgery]]. Over the decades, advancements in technology and understanding of [[critical care medicine]] have allowed ECMO to be used in a variety of clinical settings.


== Gene ==
== Indications ==
ECMO is typically indicated in cases of severe [[respiratory failure]], [[cardiac failure]], or a combination of both, when conventional therapies have failed. Common conditions that may require ECMO include:
* [[Acute respiratory distress syndrome]] (ARDS)
* [[Cardiogenic shock]]
* [[Sepsis]]
* [[Congenital diaphragmatic hernia]] in newborns


The ECPLA gene is located on the [[chromosome]] 1q25.3. It spans approximately 20 kilobases and consists of 6 [[exon]]s. The gene is expressed in various tissues, with the highest expression levels found in the [[liver]], [[kidney]], and [[heart]].
== Types of ECMO ==
There are two main types of ECMO:


== Clinical significance ==
=== Veno-Arterial (VA) ECMO ===
VA ECMO is used primarily for cardiac support. Blood is drained from the [[venous system]], oxygenated, and then returned to the [[arterial system]]. This type of ECMO provides both respiratory and circulatory support.


Alterations in the ECPLA gene or protein function could potentially lead to disorders related to inflammation, blood clotting, and vasoconstriction. However, more research is needed to fully understand the clinical significance of ECPLA.
=== Veno-Venous (VV) ECMO ===
VV ECMO is used for respiratory support only. Blood is drained from the venous system, oxygenated, and returned to the venous system. It is typically used in cases of severe respiratory failure where the heart function is adequate.


== See also ==
== Components of ECMO ==
The ECMO circuit consists of several key components:
* '''Cannulae''': Tubes inserted into the blood vessels to allow blood to be drained and returned.
* '''Pump''': A mechanical device that circulates blood through the circuit.
* '''Oxygenator''': A device that adds oxygen to the blood and removes carbon dioxide.
* '''Heat exchanger''': Regulates the temperature of the blood.


* [[Eicosapentaenoic acid]]
== Complications ==
* [[Omega-3 fatty acid]]
While ECMO can be life-saving, it is associated with several potential complications, including:
* [[Prostaglandin]]
* [[Bleeding]] due to anticoagulation
* [[Leukotriene]]
* [[Infection]]
* [[Thromboxane]]
* [[Thrombosis]]
* [[Neurological injury]]


[[Category:Human proteins]]
== Weaning and Decannulation ==
[[Category:Genes on human chromosome 1]]
Weaning from ECMO involves gradually reducing the support provided by the machine as the patient's heart and lungs recover. Decannulation is the process of removing the cannulae once the patient no longer requires ECMO support.
{{protein-stub}}
 
{{gene-stub}}
== Related pages ==
* [[Cardiopulmonary bypass]]
* [[Intensive care medicine]]
* [[Mechanical ventilation]]
 
[[Category:Medical procedures]]
[[Category:Intensive care medicine]]

Latest revision as of 03:25, 13 February 2025


Overview[edit]

Diagram of ECMO circuit

Extracorporeal Membrane Oxygenation (ECMO) is a form of extracorporeal life support used in patients with severe and life-threatening illness that prevents the heart and lungs from functioning properly. ECMO provides prolonged cardiac and respiratory support by removing blood from the body, oxygenating it, and then returning it to the patient.

History[edit]

The development of ECMO began in the 1950s with the advent of the heart-lung machine, which was used during cardiac surgery. Over the decades, advancements in technology and understanding of critical care medicine have allowed ECMO to be used in a variety of clinical settings.

Indications[edit]

ECMO is typically indicated in cases of severe respiratory failure, cardiac failure, or a combination of both, when conventional therapies have failed. Common conditions that may require ECMO include:

Types of ECMO[edit]

There are two main types of ECMO:

Veno-Arterial (VA) ECMO[edit]

VA ECMO is used primarily for cardiac support. Blood is drained from the venous system, oxygenated, and then returned to the arterial system. This type of ECMO provides both respiratory and circulatory support.

Veno-Venous (VV) ECMO[edit]

VV ECMO is used for respiratory support only. Blood is drained from the venous system, oxygenated, and returned to the venous system. It is typically used in cases of severe respiratory failure where the heart function is adequate.

Components of ECMO[edit]

The ECMO circuit consists of several key components:

  • Cannulae: Tubes inserted into the blood vessels to allow blood to be drained and returned.
  • Pump: A mechanical device that circulates blood through the circuit.
  • Oxygenator: A device that adds oxygen to the blood and removes carbon dioxide.
  • Heat exchanger: Regulates the temperature of the blood.

Complications[edit]

While ECMO can be life-saving, it is associated with several potential complications, including:

Weaning and Decannulation[edit]

Weaning from ECMO involves gradually reducing the support provided by the machine as the patient's heart and lungs recover. Decannulation is the process of removing the cannulae once the patient no longer requires ECMO support.

Related pages[edit]