Alclometasone dipropionate: Difference between revisions
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== | {{Short description|A synthetic corticosteroid used in dermatology}} | ||
{{Drugbox | |||
| verifiedfields = changed | |||
| verifiedrevid = 477002123 | |||
| IUPAC_name = (7''R'',8''S'',9''S'',10''R'',11''S'',13''S'',14''S'',17''R'')-17-[(2''S'')-2-chloroacetyl]-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6''H''-cyclopenta[a]phenanthren-17-yl propanoate | |||
| image = Alclometasone_dipropionate.svg | |||
| width = 200 | |||
| tradename = Aclovate | |||
| class = Corticosteroid | |||
}} | |||
'''Alclometasone dipropionate''' is a [[synthetic]] [[corticosteroid]] used in | '''Alclometasone dipropionate''' is a [[synthetic]] [[corticosteroid]] used in [[dermatology]] for its anti-inflammatory and antipruritic properties. It is commonly prescribed for the treatment of various [[skin]] conditions such as [[eczema]], [[dermatitis]], and [[psoriasis]]. | ||
== Pharmacology == | ==Pharmacology== | ||
Alclometasone dipropionate is a medium-potency corticosteroid that works by reducing inflammation and suppressing the immune response in the skin. It is applied topically and is absorbed through the skin to exert its effects. | |||
===Mechanism of Action=== | |||
Corticosteroids like alclometasone dipropionate bind to [[glucocorticoid receptors]] in the skin cells. This binding leads to the modulation of gene expression, resulting in decreased production of inflammatory mediators such as [[cytokines]] and [[prostaglandins]]. | |||
=== | ==Clinical Use== | ||
Alclometasone dipropionate is indicated for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. It is available in cream and ointment formulations and is typically applied to the affected area two to three times daily. | |||
==Side Effects== | |||
Common side effects of alclometasone dipropionate include burning, itching, and irritation at the site of application. Prolonged use can lead to skin thinning, [[striae]], and [[telangiectasia]]. | |||
== | ==Contraindications== | ||
Alclometasone dipropionate should not be used in patients with known hypersensitivity to any of the components of the preparation. It is also contraindicated in viral, fungal, or bacterial skin infections unless appropriate antimicrobial therapy is also administered. | |||
Alclometasone dipropionate | |||
==Related pages== | |||
* [[Corticosteroid]] | |||
* [[Dermatitis]] | |||
* [[Psoriasis]] | |||
* [[Eczema]] | * [[Eczema]] | ||
[[Category:Corticosteroids]] | [[Category:Corticosteroids]] | ||
[[Category:Dermatologic drugs]] | [[Category:Dermatologic drugs]] | ||
Revision as of 03:12, 12 February 2025
A synthetic corticosteroid used in dermatology
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| Drug class | Corticosteroid |
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Alclometasone dipropionate is a synthetic corticosteroid used in dermatology for its anti-inflammatory and antipruritic properties. It is commonly prescribed for the treatment of various skin conditions such as eczema, dermatitis, and psoriasis.
Pharmacology
Alclometasone dipropionate is a medium-potency corticosteroid that works by reducing inflammation and suppressing the immune response in the skin. It is applied topically and is absorbed through the skin to exert its effects.
Mechanism of Action
Corticosteroids like alclometasone dipropionate bind to glucocorticoid receptors in the skin cells. This binding leads to the modulation of gene expression, resulting in decreased production of inflammatory mediators such as cytokines and prostaglandins.
Clinical Use
Alclometasone dipropionate is indicated for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. It is available in cream and ointment formulations and is typically applied to the affected area two to three times daily.
Side Effects
Common side effects of alclometasone dipropionate include burning, itching, and irritation at the site of application. Prolonged use can lead to skin thinning, striae, and telangiectasia.
Contraindications
Alclometasone dipropionate should not be used in patients with known hypersensitivity to any of the components of the preparation. It is also contraindicated in viral, fungal, or bacterial skin infections unless appropriate antimicrobial therapy is also administered.
