Alclometasone dipropionate

A synthetic corticosteroid used in dermatology

Alclometasone dipropionate
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Drug class	Corticosteroid
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Pregnancy category
Bioavailability
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Elimination half-life
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Alclometasone dipropionate is a synthetic corticosteroid used in dermatology for its anti-inflammatory and antipruritic properties. It is commonly prescribed for the treatment of various skin conditions such as eczema, dermatitis, and psoriasis.

Pharmacology

Alclometasone dipropionate is a medium-potency corticosteroid that works by reducing inflammation and suppressing the immune response in the skin. It is applied topically and is absorbed through the skin to exert its effects.

Mechanism of Action

Corticosteroids like alclometasone dipropionate bind to glucocorticoid receptors in the skin cells. This binding leads to the modulation of gene expression, resulting in decreased production of inflammatory mediators such as cytokines and prostaglandins.

Clinical Use

Alclometasone dipropionate is indicated for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. It is available in cream and ointment formulations and is typically applied to the affected area two to three times daily.

Side Effects

Common side effects of alclometasone dipropionate include burning, itching, and irritation at the site of application. Prolonged use can lead to skin thinning, striae, and telangiectasia.

Contraindications

Alclometasone dipropionate should not be used in patients with known hypersensitivity to any of the components of the preparation. It is also contraindicated in viral, fungal, or bacterial skin infections unless appropriate antimicrobial therapy is also administered.

Related pages

• Corticosteroid
• Dermatitis
• Psoriasis
• Eczema

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  Alclometasone dipropionate