Generalized pustular psoriasis

Generalized pustular psoriasis (GPP) is a rare, severe form of psoriasis that is characterized by widespread pustules, high fever, and systemic symptoms. It can occur with or without previous psoriasis conditions or history.

Symptoms

The primary symptom of GPP is the sudden onset of widespread, coalescent pustules. These are not infectious, but they are painful and can cause significant discomfort. Other symptoms can include:

• Fever
• Fatigue
• Chills
• Weight loss
• Muscle weakness
• Rapid pulse

Causes

The exact cause of GPP is unknown, but it is believed to be an autoinflammatory disease, which means it is caused by a malfunctioning immune system. It can be triggered by various factors, including:

• Infections
• Stress
• Sunburn
• Medications
• Pregnancy
• Menstruation

Diagnosis

Diagnosis of GPP is based on the clinical presentation and the exclusion of other conditions. A skin biopsy may be performed to confirm the diagnosis.

Treatment

Treatment of GPP is aimed at managing the symptoms and preventing complications. This can include:

• Topical treatments
• Systemic medications
• Phototherapy
• Biologic therapies

Prognosis

The prognosis for GPP varies. Some people may experience a single episode and never have another, while others may have recurring episodes. It can be life-threatening if not treated promptly and appropriately.

See also

• Psoriasis
• Pustular psoriasis
• Autoinflammatory diseases

References

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