Tulobuterol: Difference between revisions

Tulobuterol
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Revision as of 23:45, 9 February 2025

A bronchodilator used in the treatment of asthma and COPD

Tulobuterol is a bronchodilator medication used in the management of asthma and chronic obstructive pulmonary disease (COPD). It is a beta-2 adrenergic receptor agonist that helps to relax the muscles in the airways, improving breathing in patients with obstructive airway diseases.

Pharmacology

Tulobuterol works by stimulating beta-2 adrenergic receptors in the lungs, leading to the relaxation of bronchial smooth muscle. This action helps to open up the airways, making it easier for patients to breathe. The drug is typically administered via a transdermal patch, which provides a steady release of medication over time.

Administration

Tulobuterol is commonly administered using a transdermal patch known as the Hokunalin tape. This method of delivery allows for continuous absorption of the drug through the skin, maintaining stable blood levels and providing prolonged bronchodilation.

Synthesis

The synthesis of tulobuterol involves several chemical reactions, starting from basic organic compounds. The process includes the formation of the tert-butylamino group and the attachment of the 2-chlorophenyl group to the propan-2-ol backbone.

Schematic of tulobuterol synthesis

Side Effects

Common side effects of tulobuterol include tremor, headache, and palpitations. As with other beta-2 agonists, there is a risk of tachycardia and hypokalemia. Patients are advised to monitor for any adverse reactions and consult their healthcare provider if they experience significant side effects.

Related pages

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-'''Tulobuterol''' is a long-acting [[beta2 adrenergic receptor agonist]] (LABA) used in the management of [[asthma]] and [[chronic obstructive pulmonary disease]] (COPD). It is marketed under the brand names ''Tulobuterol patch'', ''Tulobuterol tape'', and ''Tulobuterol sheet'' in Japan and South Korea.
+{{Short description|A bronchodilator used in the treatment of asthma and COPD}}
+{{Drugbox
+| verifiedfields = changed
+| verifiedrevid = 477002123
+| IUPAC_name = (RS)-1-(tert-butylamino)-3-(2-chlorophenyl)propan-2-ol
+| image = Tulobuterol.svg
+| width = 200
+}}
-==Etymology==
+'''Tulobuterol''' is a [[bronchodilator]] medication used in the management of [[asthma]] and [[chronic obstructive pulmonary disease]] (COPD). It is a [[beta-2 adrenergic receptor agonist]] that helps to relax the muscles in the airways, improving breathing in patients with obstructive airway diseases.
-The name "Tulobuterol" is derived from its chemical structure, which includes a tert-butyl group and a phenol group. The "Tulo-" prefix is derived from "tert-butyl", and the "-buterol" suffix is common among other beta2 adrenergic receptor agonists, such as [[salbutamol]] and [[terbutaline]].
 ==Pharmacology==
-Tulobuterol acts as a [[bronchodilator]], relaxing the smooth muscle in the airways to improve breathing. It is a selective beta2 adrenergic receptor agonist, meaning it primarily acts on the beta2 adrenergic receptors in the lungs. This selectivity helps to minimize side effects associated with stimulation of beta1 adrenergic receptors, such as increased heart rate.
+Tulobuterol works by stimulating [[beta-2 adrenergic receptors]] in the lungs, leading to the relaxation of bronchial smooth muscle. This action helps to open up the airways, making it easier for patients to breathe. The drug is typically administered via a transdermal patch, which provides a steady release of medication over time.
-==Clinical Use==
+==Administration==
-Tulobuterol is used in the treatment of asthma and COPD. It is typically administered via a transdermal patch, which allows for continuous delivery of the drug over a 24-hour period. This method of administration provides consistent bronchodilation and is convenient for patients, as it only requires once-daily application.
+Tulobuterol is commonly administered using a transdermal patch known as the [[Hokunalin tape]]. This method of delivery allows for continuous absorption of the drug through the skin, maintaining stable blood levels and providing prolonged bronchodilation.
+[[File:Hokunalin_tape.png|thumb|right|Hokunalin tape, a transdermal patch for tulobuterol administration]]
+==Synthesis==
+The synthesis of tulobuterol involves several chemical reactions, starting from basic organic compounds. The process includes the formation of the tert-butylamino group and the attachment of the 2-chlorophenyl group to the propan-2-ol backbone.
+[[File:Tulobuterol_synthesis.svg|thumb|right|Schematic of tulobuterol synthesis]]
 ==Side Effects==
-Common side effects of Tulobuterol include [[palpitations]], [[tremor]], and [[headache]]. Less common side effects may include [[hypokalemia]], [[hyperglycemia]], and [[muscle cramps]]. As with all LABAs, there is a risk of paradoxical bronchospasm, where the medication causes the airways to narrow instead of widen.
+Common side effects of tulobuterol include [[tremor]], [[headache]], and [[palpitations]]. As with other beta-2 agonists, there is a risk of [[tachycardia]] and [[hypokalemia]]. Patients are advised to monitor for any adverse reactions and consult their healthcare provider if they experience significant side effects.
-==See Also==
+==Related pages==
-* [[Beta2 adrenergic receptor agonist]]
 * [[Asthma]]
 * [[Chronic obstructive pulmonary disease]]
+* [[Beta-2 adrenergic receptor agonist]]
-[[Category:Drugs]]
+[[Category:Beta-2 adrenergic agonists]]
-[[Category:Pharmacology]]
+[[Category:Bronchodilators]]
-[[Category:Respiratory system]]
-{{stub}}