Triflupromazine: Difference between revisions

Revision as of 20:55, 9 February 2025

Triflupromazine

Triflupromazine is a typical antipsychotic medication belonging to the phenothiazine class. It is primarily used in the treatment of schizophrenia and other psychotic disorders. Triflupromazine is known for its sedative properties and is sometimes used to manage severe nausea and vomiting.

Chemical Structure

Triflupromazine is a derivative of phenothiazine, characterized by the presence of a trifluoromethyl group. Its chemical formula is C₁₈H₁₉F₃N₂S, and it has a molecular weight of 352.42 g/mol. The structure of triflupromazine can be visualized in the following images:

Pharmacology

Triflupromazine works by blocking dopamine receptors in the brain, which helps to reduce symptoms of psychosis. It also has antihistaminic and anticholinergic properties, contributing to its sedative effects. The medication is metabolized in the liver and excreted primarily in the urine.

Medical Uses

Triflupromazine is used to treat a variety of psychiatric conditions, including:

It is also used as an antiemetic to control severe nausea and vomiting, particularly in patients undergoing chemotherapy.

Side Effects

Common side effects of triflupromazine include:

Serious side effects may include:

History

Triflupromazine was first introduced in the 1950s as one of the early antipsychotic medications. It was developed as part of the phenothiazine class, which includes other well-known antipsychotics such as chlorpromazine.

Related Pages

@@ Line 1: / Line 1: @@
-'''Triflupromazine''' is a [[Phenothiazine|phenothiazine]] derivative that is used as an [[Antipsychotic|antipsychotic]] and [[Antiemetic|antiemetic]] medication. It is a member of the [[Thioxanthene|thioxanthene]] class of drugs and was developed in the 1950s.
+== Triflupromazine ==
-==Pharmacology==
+'''Triflupromazine''' is a [[typical antipsychotic]] medication belonging to the [[phenothiazine]] class. It is primarily used in the treatment of [[schizophrenia]] and other psychotic disorders. Triflupromazine is known for its sedative properties and is sometimes used to manage severe [[nausea]] and [[vomiting]].
-Triflupromazine works by blocking [[Dopamine receptor|dopamine receptors]] in the brain, which helps to reduce psychotic symptoms such as hallucinations, delusions, and disorganized thinking. It also has antiemetic properties, meaning it can be used to treat nausea and vomiting.
-==Medical uses==
+=== Chemical Structure ===
-Triflupromazine is used to treat a variety of conditions, including [[Schizophrenia|schizophrenia]], [[Bipolar disorder|bipolar disorder]], and severe nausea and vomiting. It can also be used to calm and sedate patients before surgery or other medical procedures.
+Triflupromazine is a derivative of [[phenothiazine]], characterized by the presence of a trifluoromethyl group. Its chemical formula is C<sub>18</sub>H<sub>19</sub>F<sub>3</sub>N<sub>2</sub>S, and it has a molecular weight of 352.42 g/mol. The structure of triflupromazine can be visualized in the following images:
-==Side effects==
+[[File:Triflupromazine.svg|thumb|Chemical structure of Triflupromazine]]
-Like all medications, triflupromazine can cause side effects. These may include drowsiness, dizziness, dry mouth, constipation, and blurred vision. In rare cases, it can cause serious side effects such as [[Tardive dyskinesia|tardive dyskinesia]], a condition characterized by involuntary movements of the face and body.
+[[File:Triflupromazine3d.png|thumb|3D model of Triflupromazine]]
-==History==
+=== Pharmacology ===
-Triflupromazine was first synthesized in the 1950s as part of a class of drugs known as phenothiazines. These drugs were initially developed as antihistamines, but were later found to have antipsychotic properties.
+Triflupromazine works by blocking [[dopamine]] receptors in the brain, which helps to reduce symptoms of psychosis. It also has antihistaminic and anticholinergic properties, contributing to its sedative effects. The medication is metabolized in the liver and excreted primarily in the urine.
-==See also==
+=== Medical Uses ===
+Triflupromazine is used to treat a variety of psychiatric conditions, including:
+* [[Schizophrenia]]
+* Severe [[anxiety]]
+* [[Mania]]
+It is also used as an antiemetic to control severe nausea and vomiting, particularly in patients undergoing [[chemotherapy]].
+=== Side Effects ===
+Common side effects of triflupromazine include:
+* [[Drowsiness]]
+* [[Dry mouth]]
+* [[Constipation]]
+* [[Blurred vision]]
+Serious side effects may include:
+* [[Tardive dyskinesia]]
+* [[Neuroleptic malignant syndrome]]
+* [[Agranulocytosis]]
+=== History ===
+Triflupromazine was first introduced in the 1950s as one of the early antipsychotic medications. It was developed as part of the phenothiazine class, which includes other well-known antipsychotics such as [[chlorpromazine]].
+=== Related Pages ===
+* [[Antipsychotic]]
 * [[Phenothiazine]]
-* [[Antipsychotic]]
+* [[Schizophrenia]]
-* [[Antiemetic]]
+* [[Dopamine receptor antagonist]]
+{{Reflist}}
-{{Phenothiazine antipsychotics}}
+[[Category:Antipsychotics]]
-{{Antiemetics}}
 [[Category:Phenothiazines]]
-[[Category:Antipsychotics]]
-[[Category:Antiemetics]]
-{{medicine-stub}}