Trestolone acetate: Difference between revisions

Revision as of 15:47, 9 February 2025

Synthetic anabolic-androgenic steroid

Trestolone acetate, also known as 7_-methyl-19-nortestosterone 17_-acetate (MENT), is a synthetic anabolic-androgenic steroid (AAS) and a derivative of nandrolone. It is primarily used in scientific research and has been investigated for potential applications in male contraception and hormone replacement therapy.

Chemical structure and properties

Trestolone acetate is a nandrolone derivative, characterized by the presence of a methyl group at the 7_ position. This modification enhances its androgenic and anabolic activity compared to nandrolone. The acetate ester attached to the 17_-hydroxyl group prolongs its duration of action by slowing its release into the bloodstream.

Pharmacology

Trestolone acetate acts as a potent agonist of the androgen receptor (AR), which mediates its anabolic and androgenic effects. It has been shown to have a high binding affinity for the AR, leading to significant increases in muscle mass and strength. Unlike testosterone, trestolone acetate does not undergo conversion to dihydrotestosterone (DHT), which may reduce the risk of certain androgenic side effects.

Potential applications

Male contraception

Trestolone acetate has been studied as a potential male contraceptive due to its ability to suppress spermatogenesis while maintaining libido and other androgen-dependent functions. Clinical trials have explored its efficacy in combination with other hormones, such as progestins, to achieve effective contraception.

Hormone replacement therapy

In hormone replacement therapy for men with hypogonadism, trestolone acetate may offer advantages over traditional testosterone therapy. Its potent anabolic effects and lack of conversion to DHT make it a promising candidate for maintaining muscle mass and bone density.

Side effects

As with other AAS, trestolone acetate can cause a range of side effects, including acne, gynecomastia, and cardiovascular issues. Long-term use may also lead to liver damage and alterations in lipid profiles.

Legal status

The legal status of trestolone acetate varies by country. In some regions, it is classified as a controlled substance, while in others, it is available for research purposes only.

Related pages

References

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-'''Trestolone acetate''' (also known as '''7α-methyl-19-nortestosterone''' (MENT), '''MENT Acetate''' or '''MENT Act''') is a synthetic and injected anabolic–androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone) which was never marketed. It is a potent agonist of the androgen receptor (AR) and hence is a powerful androgen and anabolic.
+{{Short description|Synthetic anabolic-androgenic steroid}}
+{{Use dmy dates|date=October 2023}}
-==Chemistry==
+'''Trestolone acetate''', also known as '''7_-methyl-19-nortestosterone 17_-acetate''' (MENT), is a synthetic [[anabolic-androgenic steroid]] (AAS) and a derivative of [[nandrolone]]. It is primarily used in scientific research and has been investigated for potential applications in [[male contraception]] and [[hormone replacement therapy]].
-Trestolone acetate, as mentioned, is a synthetic derivative of [[nandrolone]]. It is characterized by a modification at the 7th position with a methyl group which increases its androgenic potency. The acetate ester in trestolone acetate increases its solubility in oil, which allows the drug to have a longer half-life and to be provided in an injectable form.
+==Chemical structure and properties==
+Trestolone acetate is a [[nandrolone]] derivative, characterized by the presence of a methyl group at the 7_ position. This modification enhances its [[androgenic]] and [[anabolic]] activity compared to nandrolone. The acetate ester attached to the 17_-hydroxyl group prolongs its duration of action by slowing its release into the bloodstream.
 ==Pharmacology==
-As an [[AAS]], trestolone acetate is an agonist of the [[androgen receptor]], the biological target of androgens like testosterone and dihydrotestosterone. It has strong androgenic effects and moderate anabolic effects, which make it useful for producing masculinization and suitable for androgen replacement therapy. Trestolone acetate is a potent agonist of the androgen receptor and hence is a powerful androgen.
+Trestolone acetate acts as a potent agonist of the [[androgen receptor]] (AR), which mediates its anabolic and androgenic effects. It has been shown to have a high binding affinity for the AR, leading to significant increases in muscle mass and strength. Unlike [[testosterone]], trestolone acetate does not undergo conversion to [[dihydrotestosterone]] (DHT), which may reduce the risk of certain androgenic side effects.
+==Potential applications==
+===Male contraception===
+Trestolone acetate has been studied as a potential [[male contraceptive]] due to its ability to suppress [[spermatogenesis]] while maintaining [[libido]] and other androgen-dependent functions. Clinical trials have explored its efficacy in combination with other hormones, such as [[progestins]], to achieve effective contraception.
-==Medical uses==
+===Hormone replacement therapy===
-Trestolone acetate is currently being researched for its potential uses in male contraception and testosterone replacement therapy. Due to its potent androgenic effects, it can effectively suppress the production of gonadotropins and prevent the testes from producing sperm, making it a potential candidate for male contraception. In testosterone replacement therapy, it can be used to restore normal levels of testosterone in those with low testosterone levels.
+In [[hormone replacement therapy]] for men with [[hypogonadism]], trestolone acetate may offer advantages over traditional testosterone therapy. Its potent anabolic effects and lack of conversion to DHT make it a promising candidate for maintaining muscle mass and bone density.
 ==Side effects==
-Like other AAS, trestolone acetate has potential side effects, most notably its virilizing effects such as acne, increased body and facial hair growth, and deepening of the voice. It can also have adverse effects on cholesterol levels, liver function, and cardiovascular health.
+As with other AAS, trestolone acetate can cause a range of side effects, including [[acne]], [[gynecomastia]], and [[cardiovascular]] issues. Long-term use may also lead to [[liver damage]] and alterations in [[lipid profiles]].
+==Legal status==
+The legal status of trestolone acetate varies by country. In some regions, it is classified as a controlled substance, while in others, it is available for research purposes only.
-==See also==
+==Related pages==
 * [[Anabolic steroid]]
-* [[Androgen replacement therapy]]
+* [[Nandrolone]]
+* [[Testosterone]]
 * [[Male contraception]]
 ==References==
-<references />
+{{Reflist}}
 [[Category:Anabolic steroids]]
-[[Category:Androgens]]
+[[Category:Androgens and anabolic steroids]]
-[[Category:Male contraception]]
+[[Category:Hormonal contraception]]
-[[Category:Testosterone]]
+[[Category:Experimental drugs]]
-{{Anabolic steroid-stub}}
-{{Pharma-stub}}
+[[File:Trestolone_acetate.svg|thumb|Chemical structure of trestolone acetate]]