Vero cell: Difference between revisions

Revision as of 11:59, 9 February 2025

Vero Cell

Vero cells are a lineage of cells used in cell cultures. The "Vero" lineage was isolated from kidney epithelial cells extracted from an African green monkey (Chlorocebus sabaeus).

History

Vero cells were developed on March 27, 1962, by Yasumura and Kawakita at the Chiba University in Chiba, Japan. The name "Vero" is derived from an abbreviation of "Verda Reno," which means "green kidney" in Esperanto, referring to the origin of the cells from the kidney of the African green monkey.

Characteristics

Vero cells are continuous and aneuploid, meaning they have an abnormal number of chromosomes. They are non-tumorigenic, which makes them suitable for use in the production of vaccines and other biological products. Vero cells are particularly useful because they are easy to maintain and grow in culture, and they are susceptible to a wide range of viruses, making them ideal for virology research.

Applications

Vero cells are widely used in the production of vaccines, including those for polio, rabies, and smallpox. They are also used in the study of viral pathogenesis and the development of antiviral drugs.

Advantages and Limitations

One of the main advantages of Vero cells is their ability to grow in a serum-free medium, which reduces the risk of contamination with animal-derived pathogens. However, a limitation is that they are aneuploid, which can lead to genetic instability over time.

Related pages

References

Yasumura, Y., & Kawakita, Y. (1963). The research for the SV40 by means of tissue culture technique. Nippon Rinsho.
Barile, M. F., & Hopps, H. E. (1969). Vero cell culture as a substrate for viral vaccine production. Developments in Biological Standardization.

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-'''Vero cells''' are a type of cell line that is widely used in virology and other biological research areas. Originating from the kidney epithelial cells extracted from an African green monkey ([[Cercopithecus aethiops]]), Vero cells are known for their ability to grow in culture and are used for the production of viral vaccines and for research on viral pathogens.
+== Vero Cell ==
-==History==
+[[File:Vero_cells.jpg|thumb|Vero cells under a microscope]]
-Vero cells were first isolated in 1962 by Y. Yasumura and Y. Kawakita at the Chiba University in Japan. The name "Vero" is derived from "verda reno," which means "green kidney" in Esperanto, reflecting the cells' origin. Since their discovery, Vero cells have become one of the most important cell lines in virology due to their high efficiency in propagating viruses.
-==Characteristics==
+'''Vero cells''' are a lineage of cells used in cell cultures. The "Vero" lineage was isolated from kidney epithelial cells extracted from an African green monkey (''Chlorocebus sabaeus'').
-Vero cells are characterized by their fibroblast-like shape and their ability to reach high cell densities in culture. Unlike many other cell lines, Vero cells do not produce interferon, a type of protein that is part of the immune response against viral infections. This lack of interferon production allows viruses to replicate more efficiently, making Vero cells an ideal tool for virology research.
-==Applications==
+== History ==
-Vero cells are used in a variety of research and industrial applications. One of the most significant uses of Vero cells is in the production of viral vaccines. They are used to propagate viruses for vaccines against diseases such as polio, rabies, and smallpox. In addition to vaccine production, Vero cells are also used in basic research to study viral life cycles, pathogenesis, and host-virus interactions.
-==Safety and Regulation==
+Vero cells were developed on March 27, 1962, by Yasumura and Kawakita at the Chiba University in Chiba, Japan. The name "Vero" is derived from an abbreviation of "Verda Reno," which means "green kidney" in Esperanto, referring to the origin of the cells from the kidney of the African green monkey.
-The use of Vero cells in vaccine production is subject to strict regulatory oversight to ensure the safety and efficacy of vaccines. The World Health Organization (WHO) and other regulatory bodies have established guidelines for the use of cell lines in vaccine manufacture, including the characterization and testing of cell lines for contaminants.
-==Controversies==
+== Characteristics ==
-The use of Vero cells, like other animal-derived cell lines, has raised ethical concerns regarding animal welfare and the use of animals in scientific research. Additionally, there have been concerns about the potential for contamination with animal viruses, which could pose risks to human health. However, rigorous testing and regulatory standards are in place to minimize these risks.
-==Future Directions==
+Vero cells are continuous and aneuploid, meaning they have an abnormal number of chromosomes. They are non-tumorigenic, which makes them suitable for use in the production of vaccines and other biological products. Vero cells are particularly useful because they are easy to maintain and grow in culture, and they are susceptible to a wide range of viruses, making them ideal for virology research.
-Research on Vero cells continues to evolve, with ongoing studies aimed at improving the safety and efficiency of these cells for vaccine production and other applications. Advances in genetic engineering and cell culture technology may lead to the development of new Vero cell lines with enhanced properties for research and industrial use.
-[[Category:Cell biology]]
+== Applications ==
+Vero cells are widely used in the production of [[vaccines]], including those for [[polio]], [[rabies]], and [[smallpox]]. They are also used in the study of [[viral pathogenesis]] and the development of [[antiviral drugs]].
+== Advantages and Limitations ==
+One of the main advantages of Vero cells is their ability to grow in a serum-free medium, which reduces the risk of contamination with animal-derived pathogens. However, a limitation is that they are aneuploid, which can lead to genetic instability over time.
+== Related pages ==
+* [[Cell culture]]
+* [[Vaccine production]]
+* [[Virology]]
+== References ==
+* Yasumura, Y., & Kawakita, Y. (1963). The research for the SV40 by means of tissue culture technique. ''Nippon Rinsho''.
+* Barile, M. F., & Hopps, H. E. (1969). Vero cell culture as a substrate for viral vaccine production. ''Developments in Biological Standardization''.
+{{Cell culture}}
+[[Category:Cell lines]]
 [[Category:Virology]]
-[[Category:Biotechnology]]
-{{Cell-biology-stub}}
-{{Virology-stub}}