ING2: Difference between revisions
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{{Infobox protein | {{Infobox protein | ||
| name = Inhibitor of growth protein 2 | | name = Inhibitor of growth protein 2 | ||
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| UniProt = Q9H160 | | UniProt = Q9H160 | ||
}} | }} | ||
'''Inhibitor of growth protein 2''' ('''ING2''') is a protein that in humans is encoded by the [[ING2 gene]]. | '''Inhibitor of growth protein 2''' ('''ING2''') is a protein that in humans is encoded by the [[ING2 gene]]. | ||
== Function == | == Function == | ||
ING2 is a member of the [[inhibitor of growth family]] of proteins, which are involved in [[chromatin remodeling]] and [[gene expression]]. ING2 plays a role in the regulation of [[cell cycle]], [[apoptosis]], and [[DNA repair]]. It is known to interact with the [[p53]] tumor suppressor protein and is involved in the [[p53 signaling pathway]]. | ING2 is a member of the [[inhibitor of growth family]] of proteins, which are involved in [[chromatin remodeling]] and [[gene expression]]. ING2 plays a role in the regulation of [[cell cycle]], [[apoptosis]], and [[DNA repair]]. It is known to interact with the [[p53]] tumor suppressor protein and is involved in the [[p53 signaling pathway]]. | ||
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* [[Tumor suppressor gene]] | * [[Tumor suppressor gene]] | ||
* [[Chromatin remodeling]] | * [[Chromatin remodeling]] | ||
== External links == | == External links == | ||
* [https://www.ncbi.nlm.nih.gov/gene/3622 ING2 gene - NCBI Gene] | * [https://www.ncbi.nlm.nih.gov/gene/3622 ING2 gene - NCBI Gene] | ||
* [https://www.uniprot.org/uniprot/Q9H160 ING2 protein - UniProt] | * [https://www.uniprot.org/uniprot/Q9H160 ING2 protein - UniProt] | ||
[[Category:Human proteins]] | [[Category:Human proteins]] | ||
[[Category:Tumor suppressor genes]] | [[Category:Tumor suppressor genes]] | ||
[[Category:Chromatin remodeling]] | [[Category:Chromatin remodeling]] | ||
Latest revision as of 01:50, 5 February 2025
Inhibitor of growth protein 2 (ING2) is a protein that in humans is encoded by the ING2 gene.
Function[edit]
ING2 is a member of the inhibitor of growth family of proteins, which are involved in chromatin remodeling and gene expression. ING2 plays a role in the regulation of cell cycle, apoptosis, and DNA repair. It is known to interact with the p53 tumor suppressor protein and is involved in the p53 signaling pathway.
Clinical significance[edit]
Alterations in the expression of ING2 have been associated with various types of cancer, including breast cancer, colorectal cancer, and melanoma. ING2 is considered a potential tumor suppressor gene, and its loss of function may contribute to tumorigenesis.
Interactions[edit]
ING2 has been shown to interact with several proteins, including:
These interactions suggest that ING2 is involved in the regulation of chromatin structure and gene transcription.
