ING2: Difference between revisions

Revision as of 20:26, 30 December 2024

Inhibitor of growth protein 2 (ING2) is a protein that in humans is encoded by the ING2 gene.

Function

ING2 is a member of the inhibitor of growth family of proteins, which are involved in chromatin remodeling and gene expression. ING2 plays a role in the regulation of cell cycle, apoptosis, and DNA repair. It is known to interact with the p53 tumor suppressor protein and is involved in the p53 signaling pathway.

Clinical significance

Alterations in the expression of ING2 have been associated with various types of cancer, including breast cancer, colorectal cancer, and melanoma. ING2 is considered a potential tumor suppressor gene, and its loss of function may contribute to tumorigenesis.

Interactions

ING2 has been shown to interact with several proteins, including:

These interactions suggest that ING2 is involved in the regulation of chromatin structure and gene transcription.

References

External links

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-'''ING2''' or '''Inhibitor of Growth Family, Member 2''' is a [[protein]] that in humans is encoded by the ING2 [[gene]]. This protein is a member of the ING family of [[tumor suppressor]] proteins.
-== Function ==
+{{Infobox protein
+| name = Inhibitor of growth protein 2
+| symbol = ING2
+| image = <!-- Image removed -->
+| width =
+| caption =
+| HGNCid = 6059
+| EntrezGene = 3622
+| OMIM = 608053
+| RefSeq = NM_001564
+| UniProt = Q9H160
+}}
-The ING2 protein is a [[nuclear protein]] that physically interacts with the [[tumor suppressor]] protein [[p53]] and is a component of the [[mSin3a]] family of [[histone deacetylase]] complexes (HDAC). The ING2 protein is involved in numerous cellular processes including [[cell cycle]] control, [[apoptosis]], and [[DNA repair]].
+'''Inhibitor of growth protein 2''' ('''ING2''') is a protein that in humans is encoded by the [[ING2 gene]].
-== Structure ==
+== Function ==
+ING2 is a member of the [[inhibitor of growth family]] of proteins, which are involved in [[chromatin remodeling]] and [[gene expression]]. ING2 plays a role in the regulation of [[cell cycle]], [[apoptosis]], and [[DNA repair]]. It is known to interact with the [[p53]] tumor suppressor protein and is involved in the [[p53 signaling pathway]].
-The ING2 protein contains a [[PHD finger]], a protein module that is implicated in [[chromatin]] recognition and [[nuclear import]]. The PHD finger of ING2 has been shown to bind to [[histone]] H3 trimethylated at lysine 4 (H3K4me3), a mark associated with [[gene activation]].
+== Clinical significance ==
+Alterations in the expression of ING2 have been associated with various types of [[cancer]], including [[breast cancer]], [[colorectal cancer]], and [[melanoma]]. ING2 is considered a potential [[tumor suppressor gene]], and its loss of function may contribute to tumorigenesis.
-== Clinical Significance ==
+== Interactions ==
+ING2 has been shown to interact with several proteins, including:
+* [[TP53]] (p53)
+* [[Histone acetyltransferase]]s
+* [[Histone deacetylase]]s
-Alterations in the ING2 gene have been associated with several types of [[cancer]], including [[breast cancer]], [[colorectal cancer]], and [[lung cancer]]. The ING2 protein may serve as a potential [[biomarker]] for these types of cancer.
+These interactions suggest that ING2 is involved in the regulation of [[chromatin structure]] and [[gene transcription]].
-[[File:ING2 protein structure.jpg|thumb|right|300px|Structure of the ING2 protein. Image from Wikimedia Commons.]]
+== See also ==
+* [[Inhibitor of growth family]]
-== See Also ==
+* [[Tumor suppressor gene]]
+* [[Chromatin remodeling]]
-* [[ING1]]
-* [[ING3]]
-* [[ING4]]
-* [[ING5]]
 == References ==
+{{Reflist}}
-<references />
+== External links ==
+* [https://www.ncbi.nlm.nih.gov/gene/3622 ING2 gene - NCBI Gene]
-{{medicine-stub}}
+* [https://www.uniprot.org/uniprot/Q9H160 ING2 protein - UniProt]
-[[Category:Proteins]]
+[[Category:Human proteins]]
 [[Category:Tumor suppressor genes]]
-[[Category:Genes]]
+[[Category:Chromatin remodeling]]
-[[Category:Oncology]]
-[[Category:Medical genetics]]