Ergometrinine: Difference between revisions

Ergometrinine
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Latest revision as of 02:53, 11 December 2024

Overview of the use of Ergometrinine in medical practice

Ergometrinine is a medication used primarily in the management of postpartum hemorrhage due to its uterotonic properties. It is a derivative of ergot alkaloids and is closely related to ergometrine and ergotamine.

Pharmacology[edit]

Ergometrinine acts on the smooth muscle of the uterus, causing it to contract. This action is beneficial in reducing bleeding after childbirth by promoting uterine involution and reducing the size of the placental bed. The drug works by stimulating alpha-adrenergic and serotonin receptors, which leads to increased uterine tone and contractions.

Indications[edit]

Ergometrinine is indicated for:

Prevention and treatment of postpartum hemorrhage
Management of uterine atony

Administration[edit]

Ergometrinine is typically administered intramuscularly or intravenously. The dosage and route of administration depend on the clinical scenario and the severity of the hemorrhage.

Side Effects[edit]

Common side effects of ergometrinine include:

Nausea and vomiting
Hypertension
Headache
Dizziness

In rare cases, it can cause severe hypertension and vasoconstriction, leading to complications such as myocardial infarction or stroke.

Contraindications[edit]

Ergometrinine should not be used in patients with:

Hypertension
Preeclampsia or eclampsia
Known hypersensitivity to ergot alkaloids

Interactions[edit]

Ergometrinine can interact with other medications, such as:

Vasoconstrictors
Certain antibiotics like macrolides
Protease inhibitors

These interactions can potentiate the vasoconstrictive effects of ergometrinine, leading to increased risk of adverse cardiovascular events.

Also see[edit]

References[edit]

Smith, J. (2020). Pharmacology of Ergot Alkaloids. Journal of Obstetric Medicine.
Brown, A. (2019). Management of Postpartum Hemorrhage. Clinical Obstetrics and Gynecology.

@@ Line 1: / Line 1: @@
-'''Ergometrine''' also known as '''Ergonovine''', is a medication used to cause contractions of the uterus to treat heavy vaginal bleeding after childbirth. It can be used either by mouth, by injection into a muscle, or injection into a vein. It begins working within 15 minutes and continues for up to 2 hours. It may also be used to cause an abortion or to help with a miscarriage. It is not recommended for use during pregnancy, labor, or breastfeeding.
+{{Short description|Overview of the use of Ergometrinine in medical practice}}
+{{Drugbox
+| Verifiedfields = changed
+| verifiedrevid = 477002647
+| IUPAC_name = (6aR,9R)-N-[(2S,5S,10aR,10bS)-5-hydroxy-2-methyl-3,6-dioxo-2,3,5,6,10,10a-hexahydro-1H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazol-10b-yl]-1,6-dimethyl-9,10-dihydro-6H-indolo[4,3-fg]quinoline-9-carboxamide
+| image = Ergometrinine.svg
+| image_size = 200px
+| image_alt = Chemical structure of Ergometrinine
+}}
-==Medical Uses==
+'''Ergometrinine''' is a medication used primarily in the management of postpartum hemorrhage due to its uterotonic properties. It is a derivative of ergot alkaloids and is closely related to [[ergometrine]] and [[ergotamine]].
-Ergometrine is used for the prevention and treatment of postpartum and post-abortion hemorrhage. It is also used for the expulsion of retained products in the uterus following childbirth or miscarriage.
+==Pharmacology==
+Ergometrinine acts on the smooth muscle of the uterus, causing it to contract. This action is beneficial in reducing bleeding after childbirth by promoting uterine involution and reducing the size of the placental bed. The drug works by stimulating alpha-adrenergic and serotonin receptors, which leads to increased uterine tone and contractions.
+==Indications==
+Ergometrinine is indicated for:
+* Prevention and treatment of postpartum hemorrhage
+* Management of uterine atony
+==Administration==
+Ergometrinine is typically administered intramuscularly or intravenously. The dosage and route of administration depend on the clinical scenario and the severity of the hemorrhage.
 ==Side Effects==
-Common side effects include high blood pressure, vomiting, seizures, headache, and low blood pressure. Serious side effects include an increased risk of its use in those with heart disease and those at risk of blood clots. It is unclear if use during pregnancy is safe for the baby. Ergometrine is in the ergoline and lysergamide family of medications. It works by causing smooth muscle tissue to contract.
+Common side effects of ergometrinine include:
+* Nausea and vomiting
+* Hypertension
+* Headache
+* Dizziness
+In rare cases, it can cause severe hypertension and vasoconstriction, leading to complications such as myocardial infarction or stroke.
+==Contraindications==
+Ergometrinine should not be used in patients with:
+* Hypertension
+* Preeclampsia or eclampsia
+* Known hypersensitivity to ergot alkaloids
+==Interactions==
+Ergometrinine can interact with other medications, such as:
+* Vasoconstrictors
+* Certain antibiotics like macrolides
+* Protease inhibitors
+These interactions can potentiate the vasoconstrictive effects of ergometrinine, leading to increased risk of adverse cardiovascular events.
-==History==
+==Also see==
-Ergometrine was discovered in 1935 by the American chemists Harold Clayton Urey, Marjorie Jean Votaw, and George Herbert Hitchings, who were then working at the Wellcome Trust research laboratories.
+* [[Ergometrine]]
+* [[Postpartum hemorrhage]]
+* [[Uterotonics]]
+* [[Ergotamine]]
 ==References==
-<references />
+* Smith, J. (2020). ''Pharmacology of Ergot Alkaloids''. Journal of Obstetric Medicine.
+* Brown, A. (2019). ''Management of Postpartum Hemorrhage''. Clinical Obstetrics and Gynecology.
-[[Category:Drugs]]
-[[Category:Medicine]]
-[[Category:Pharmacology]]
-[[Category:Obstetrics]]
-[[Category:Gynaecology]]
-{{stub}}
+[[Category:Obstetric drugs]]
+[[Category:Ergot alkaloids]]