Alternating hemiplegia: Difference between revisions
From WikiMD's Wellness Encyclopedia
No edit summary Tag: Manual revert |
CSV import |
||
| Line 1: | Line 1: | ||
{{Infobox medical condition | |||
| name = Alternating hemiplegia | |||
| synonyms = AHC | |||
| field = [[Neurology]] | |||
| symptoms = [[Paralysis]] on one side of the body, [[seizures]], [[developmental delay]], [[movement disorders]] | |||
| onset = [[Infancy]] | |||
| duration = [[Chronic (medicine)|Chronic]] | |||
| causes = [[Genetic mutation]] in the [[ATP1A3]] gene | |||
| risks = [[Family history]] | |||
| diagnosis = [[Clinical diagnosis]], [[genetic testing]] | |||
| differential = [[Epilepsy]], [[cerebral palsy]], [[migraine]] | |||
| treatment = [[Supportive care]], [[medications]] to manage symptoms | |||
| prognosis = Variable, often involves [[disability]] | |||
| frequency = Rare, estimated 1 in 1,000,000 | |||
}} | |||
Alternating hemiplegia is a rare neurological disorder. | Alternating hemiplegia is a rare neurological disorder. | ||
== Onset == | == Onset == | ||
It develops in childhood, most often before the child is 18 months old. | It develops in childhood, most often before the child is 18 months old. | ||
== Clinical features == | == Clinical features == | ||
* The disorder is characterized by recurrent episodes of [[paralysis]] that involve one or both sides of the body, multiple limbs, or a single limb. | * The disorder is characterized by recurrent episodes of [[paralysis]] that involve one or both sides of the body, multiple limbs, or a single limb. | ||
* The paralysis may affect different parts of the body at different times and may be brief or last for several days. | * The paralysis may affect different parts of the body at different times and may be brief or last for several days. | ||
Oftentimes these episodes will resolve after sleep. | Oftentimes these episodes will resolve after sleep. | ||
== Abnormal movements == | == Abnormal movements == | ||
Affected children may also have abnormal movements involving stiffening or "dance-like" movements of a limb, as well as walking and balance problems. | Affected children may also have abnormal movements involving stiffening or "dance-like" movements of a limb, as well as walking and balance problems. | ||
== Seizures == | == Seizures == | ||
Some children have seizures. Children may have normal or delayed development. | Some children have seizures. Children may have normal or delayed development. | ||
== Benign and serious forms == | == Benign and serious forms == | ||
There are both benign and more serious forms of the disorder. | There are both benign and more serious forms of the disorder. | ||
== Cause == | == Cause == | ||
* Alternating hemiplegia is primarily caused by mutations in the ATP1A3 gene. | * Alternating hemiplegia is primarily caused by mutations in the ATP1A3 gene. | ||
* Occasionally, a mutation in the ATP1A2 gene is involved in the condition. | * Occasionally, a mutation in the ATP1A2 gene is involved in the condition. | ||
== Prognosis == | == Prognosis == | ||
Children that have a milder form have relative good prognosis while those with a more severe form have bad prognosis. | Children that have a milder form have relative good prognosis while those with a more severe form have bad prognosis. | ||
== Treatment == | == Treatment == | ||
Verapamil has been used to help reduce severity of the disease. | Verapamil has been used to help reduce severity of the disease. | ||
== Sources and references == | == Sources and references == | ||
* {{NINDS|Alternating-Hemiplegia|Alternating Hemiplegia Information Page}} | * {{NINDS|Alternating-Hemiplegia|Alternating Hemiplegia Information Page}} | ||
{{neuro}} | {{neuro}} | ||
{{Ion pump disorders}} | {{Ion pump disorders}} | ||
Latest revision as of 05:34, 4 April 2025
| Alternating hemiplegia | |
|---|---|
| Synonyms | AHC |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Paralysis on one side of the body, seizures, developmental delay, movement disorders |
| Complications | N/A |
| Onset | Infancy |
| Duration | Chronic |
| Types | N/A |
| Causes | Genetic mutation in the ATP1A3 gene |
| Risks | Family history |
| Diagnosis | Clinical diagnosis, genetic testing |
| Differential diagnosis | Epilepsy, cerebral palsy, migraine |
| Prevention | N/A |
| Treatment | Supportive care, medications to manage symptoms |
| Medication | N/A |
| Prognosis | Variable, often involves disability |
| Frequency | Rare, estimated 1 in 1,000,000 |
| Deaths | N/A |
Alternating hemiplegia is a rare neurological disorder.
Onset
It develops in childhood, most often before the child is 18 months old.
Clinical features
- The disorder is characterized by recurrent episodes of paralysis that involve one or both sides of the body, multiple limbs, or a single limb.
- The paralysis may affect different parts of the body at different times and may be brief or last for several days.
Oftentimes these episodes will resolve after sleep.
Abnormal movements
Affected children may also have abnormal movements involving stiffening or "dance-like" movements of a limb, as well as walking and balance problems.
Seizures
Some children have seizures. Children may have normal or delayed development.
Benign and serious forms
There are both benign and more serious forms of the disorder.
Cause
- Alternating hemiplegia is primarily caused by mutations in the ATP1A3 gene.
- Occasionally, a mutation in the ATP1A2 gene is involved in the condition.
Prognosis
Children that have a milder form have relative good prognosis while those with a more severe form have bad prognosis.
Treatment
Verapamil has been used to help reduce severity of the disease.
Sources and references
edit
WikiMD neurology
External links
- Comprehensive information from the National Institute of health.
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
| Genetic disorder, membrane: ATPase disorders | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
see also ATPase
|
