D-α-Aminoadipate: Difference between revisions

Revision as of 20:30, 28 February 2024

D-α-Aminoadipate‏‎ (also known as D-AAA or D-alpha-aminoadipate) is a biochemical compound that plays a significant role in the metabolism of certain organisms. It is a derivative of the amino acid lysine, and is involved in the biosynthesis of lysine and several other amino acids.

Structure and Properties

D-α-Aminoadipate‏‎ is a chiral molecule, meaning it has a non-superimposable mirror image. It is the D-enantiomer of α-aminoadipate, the other being L-α-aminoadipate. The compound has a carboxyl group (-COOH) and an amino group (-NH2), making it an α-amino acid. However, unlike most α-amino acids, it is not used in the biosynthesis of proteins.

Biological Role

In certain bacteria, fungi, and algae, D-α-Aminoadipate‏‎ is an intermediate in the biosynthesis of the essential amino acid lysine. This pathway, known as the α-aminoadipate pathway, is not found in animals or plants. In the yeast Saccharomyces cerevisiae, D-α-Aminoadipate is also used in the synthesis of penicillin and other β-lactam antibiotics.

In humans and other mammals, D-α-Aminoadipate has been found to act as an excitatory amino acid neurotransmitter. It is also a potential biomarker for certain neurological and metabolic disorders.

Clinical Significance

Elevated levels of D-α-Aminoadipate in the body can be indicative of certain health conditions. For instance, it has been associated with glutaric aciduria, a rare genetic metabolic disorder. It is also being studied for its potential role in neurodegenerative diseases such as Alzheimer's disease and Huntington's disease.

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-#REDIRECT [[Α-Aminoadipic acid]]
+'''D-α-Aminoadipate‏‎''' (also known as '''D-AAA''' or '''D-alpha-aminoadipate''') is a [[biochemical]] compound that plays a significant role in the [[metabolism]] of certain organisms. It is a derivative of the [[amino acid]] [[lysine]], and is involved in the biosynthesis of lysine and several other amino acids.
-{{R category shell|
+== Structure and Properties ==
-{{R from more specific name|α-Aminoadipate}}
-{{R from avoided double redirect|α-Aminoadipate}}
+D-α-Aminoadipate‏‎ is a [[chiral]] molecule, meaning it has a non-superimposable mirror image. It is the D-[[enantiomer]] of α-aminoadipate, the other being L-α-aminoadipate. The compound has a carboxyl group (-COOH) and an amino group (-NH2), making it an α-amino acid. However, unlike most α-amino acids, it is not used in the biosynthesis of [[proteins]].
-}}
+== Biological Role ==
+In certain bacteria, fungi, and algae, D-α-Aminoadipate‏‎ is an intermediate in the [[biosynthesis]] of the essential amino acid [[lysine]]. This pathway, known as the α-aminoadipate pathway, is not found in animals or plants. In the yeast ''[[Saccharomyces cerevisiae]]'', D-α-Aminoadipate is also used in the synthesis of [[penicillin]] and other [[β-lactam antibiotics]].
+In humans and other mammals, D-α-Aminoadipate has been found to act as an [[excitatory amino acid]] neurotransmitter. It is also a potential biomarker for certain neurological and metabolic disorders.
+== Clinical Significance ==
+Elevated levels of D-α-Aminoadipate in the body can be indicative of certain health conditions. For instance, it has been associated with [[glutaric aciduria]], a rare genetic metabolic disorder. It is also being studied for its potential role in neurodegenerative diseases such as [[Alzheimer's disease]] and [[Huntington's disease]].
+== See Also ==
+* [[Lysine]]
+* [[Amino acid metabolism]]
+* [[Neurotransmitter]]
+* [[Metabolic disorder]]
+[[Category:Biochemistry]]
+[[Category:Amino acids]]
+[[Category:Neurotransmitters]]
+{{biochem-stub}}
+{{neuroscience-stub}}