Acetyldigitoxin: Difference between revisions
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{{ | {{short description|A cardiac glycoside used in the treatment of heart conditions}} | ||
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| | | image_alt = Structural formula of acetyldigitoxin | ||
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'''Acetyldigitoxin''' is a [[cardiac glycoside]] used in the treatment of certain | '''Acetyldigitoxin''' is a [[cardiac glycoside]] derived from the [[Digitalis]] plant, commonly used in the treatment of certain heart conditions. It is a derivative of [[digitoxin]], with an acetyl group added to its structure, which affects its pharmacokinetics and pharmacodynamics. | ||
==Chemical Structure== | |||
[[File:Acetyldigitoxin.png|thumb|right|200px|Structural formula of acetyldigitoxin]] | |||
Acetyldigitoxin is a glycoside composed of a steroid nucleus with a lactone ring and a series of sugar moieties. The acetylation of digitoxin alters its solubility and absorption characteristics. | |||
==Pharmacology== | ==Pharmacology== | ||
Acetyldigitoxin works by inhibiting the [[sodium-potassium ATPase]] pump | Acetyldigitoxin works by inhibiting the [[sodium-potassium ATPase]] pump, leading to an increase in intracellular sodium. This increase in sodium promotes calcium influx via the sodium-calcium exchanger, enhancing cardiac contractility. This mechanism is beneficial in conditions such as [[congestive heart failure]] and certain types of [[arrhythmias]]. | ||
==Clinical Use== | ==Clinical Use== | ||
Acetyldigitoxin is primarily | Acetyldigitoxin is used primarily in the management of heart failure and atrial fibrillation. Its long half-life allows for once-daily dosing, which can improve patient compliance. However, its narrow therapeutic index requires careful monitoring of blood levels to avoid toxicity. | ||
==Side Effects== | ==Side Effects== | ||
Common side effects of acetyldigitoxin include | Common side effects of acetyldigitoxin include nausea, vomiting, diarrhea, and confusion. More serious effects can include [[cardiac arrhythmias]], which necessitate regular monitoring of patients on this medication. | ||
==Toxicity== | ==Toxicity== | ||
Acetyldigitoxin | [[File:Acetyldigitoxin.png|thumb|left|200px|Another view of acetyldigitoxin structure]] | ||
Toxicity from acetyldigitoxin can occur due to its narrow therapeutic window. Symptoms of toxicity include gastrointestinal disturbances, visual changes, and severe arrhythmias. Treatment involves discontinuation of the drug and administration of [[digoxin-specific antibody]] fragments in severe cases. | |||
==Related pages== | ==Related pages== | ||
* [[Digitalis]] | |||
* [[Cardiac glycoside]] | * [[Cardiac glycoside]] | ||
* [[Heart failure]] | * [[Heart failure]] | ||
* [[Atrial fibrillation]] | |||
[[Category:Cardiac glycosides]] | [[Category:Cardiac glycosides]] | ||
[[Category:Drugs used in | [[Category:Drugs used in cardiovascular diseases]] | ||
Latest revision as of 11:03, 15 February 2025
A cardiac glycoside used in the treatment of heart conditions
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Acetyldigitoxin is a cardiac glycoside derived from the Digitalis plant, commonly used in the treatment of certain heart conditions. It is a derivative of digitoxin, with an acetyl group added to its structure, which affects its pharmacokinetics and pharmacodynamics.
Chemical Structure[edit]
Acetyldigitoxin is a glycoside composed of a steroid nucleus with a lactone ring and a series of sugar moieties. The acetylation of digitoxin alters its solubility and absorption characteristics.
Pharmacology[edit]
Acetyldigitoxin works by inhibiting the sodium-potassium ATPase pump, leading to an increase in intracellular sodium. This increase in sodium promotes calcium influx via the sodium-calcium exchanger, enhancing cardiac contractility. This mechanism is beneficial in conditions such as congestive heart failure and certain types of arrhythmias.
Clinical Use[edit]
Acetyldigitoxin is used primarily in the management of heart failure and atrial fibrillation. Its long half-life allows for once-daily dosing, which can improve patient compliance. However, its narrow therapeutic index requires careful monitoring of blood levels to avoid toxicity.
Side Effects[edit]
Common side effects of acetyldigitoxin include nausea, vomiting, diarrhea, and confusion. More serious effects can include cardiac arrhythmias, which necessitate regular monitoring of patients on this medication.
Toxicity[edit]
Toxicity from acetyldigitoxin can occur due to its narrow therapeutic window. Symptoms of toxicity include gastrointestinal disturbances, visual changes, and severe arrhythmias. Treatment involves discontinuation of the drug and administration of digoxin-specific antibody fragments in severe cases.
