POU4F2

POU4F2

Symbol	–
HGNC ID	9210
Alternative symbols	–
Entrez Gene	5458
OMIM	602233
RefSeq	NM_006234
UniProt	Q12837
Chromosome	–
Locus supplementary data	–

POU4F2, also known as BRN3B, is a gene that encodes a transcription factor belonging to the POU-IV class. This gene is involved in the regulation of gene expression during neurogenesis and is crucial for the development of the retina.

Function

The POU4F2 protein is a transcription factor that binds to specific DNA sequences, thereby controlling the transcription of genetic information from DNA to mRNA. It plays a significant role in the development of retinal ganglion cells and is essential for visual system development.

Clinical Significance

Mutations or dysregulation of the POU4F2 gene have been associated with various ocular diseases and neurological disorders. Research indicates that POU4F2 may be involved in the pathogenesis of glaucoma and other retinal degenerative diseases.

Interactions

POU4F2 interacts with other transcription factors and co-regulators to modulate the expression of target genes. It is known to interact with POU4F1 and POU4F3, which are also members of the POU-IV class of transcription factors.

Research

Studies on POU4F2 have provided insights into its role in neurodevelopment and its potential as a therapeutic target for retinal diseases. Ongoing research is focused on understanding the molecular mechanisms by which POU4F2 regulates gene networks involved in neuronal differentiation and survival.

See Also

• Transcription factor
• Neurogenesis
• Retinal ganglion cell
• Gene expression

References

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