Delapril: Difference between revisions

Delapril
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

Newer edit →

Revision as of 03:33, 13 February 2025

An overview of the antihypertensive drug Delapril

Delapril is a medication used primarily in the treatment of hypertension (high blood pressure). It belongs to the class of drugs known as angiotensin-converting enzyme inhibitors (ACE inhibitors), which work by relaxing blood vessels and reducing the workload on the heart.

Mechanism of action

Delapril functions by inhibiting the angiotensin-converting enzyme (ACE), which is responsible for the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, meaning it narrows blood vessels and increases blood pressure. By blocking this conversion, Delapril helps to lower blood pressure and improve blood flow.

Pharmacokinetics

Delapril is administered orally and is absorbed through the gastrointestinal tract. It is a prodrug, meaning it is metabolized into its active form, delaprilat, in the liver. The drug is then excreted primarily through the kidneys.

Clinical uses

Delapril is used to manage hypertension and may be prescribed alone or in combination with other antihypertensive agents. It is also used in the treatment of heart failure and to improve survival after a myocardial infarction (heart attack).

Side effects

Common side effects of Delapril include cough, dizziness, and fatigue. Like other ACE inhibitors, it can cause hyperkalemia (elevated potassium levels) and angioedema (swelling of the deeper layers of the skin). Patients are advised to report any signs of swelling or difficulty breathing to their healthcare provider immediately.

Contraindications

Delapril is contraindicated in patients with a history of angioedema related to previous ACE inhibitor therapy and in those with renal artery stenosis. It should not be used during pregnancy due to the risk of fetal harm.

Related pages

@@ Line 1: / Line 1: @@
-'''Delapril''' is an [[angiotensin-converting enzyme inhibitor]] (ACE inhibitor) used primarily in the treatment of [[hypertension]] and [[congestive heart failure]]. Like other ACE inhibitors, delapril works by causing relaxation of blood vessels and a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.
+{{Short description|An overview of the antihypertensive drug Delapril}}
+{{Drugbox
+| verifiedfields = changed
+| verifiedrevid = 477002123
+| image = Delapril.svg
+| image_size = 200px
+| image_alt = Structural formula of Delapril
+}}
-==Mechanism of Action==
+'''Delapril''' is a medication used primarily in the treatment of [[hypertension]] (high blood pressure). It belongs to the class of drugs known as [[angiotensin-converting enzyme inhibitors]] (ACE inhibitors), which work by relaxing blood vessels and reducing the workload on the heart.
-Delapril inhibits the angiotensin-converting enzyme, which is responsible for the conversion of [[angiotensin I]] to [[angiotensin II]]. Angiotensin II is a potent vasoconstrictor that increases blood pressure and stimulates the release of [[aldosterone]] from the adrenal glands. By inhibiting the production of angiotensin II, delapril decreases blood pressure and reduces the workload on the heart. Additionally, this medication increases levels of bradykinin, a peptide that promotes vasodilation, further contributing to its antihypertensive effects.
+==Mechanism of action==
+Delapril functions by inhibiting the [[angiotensin-converting enzyme]] (ACE), which is responsible for the conversion of [[angiotensin I]] to [[angiotensin II]]. Angiotensin II is a potent vasoconstrictor, meaning it narrows blood vessels and increases blood pressure. By blocking this conversion, Delapril helps to lower blood pressure and improve blood flow.
 ==Pharmacokinetics==
-Delapril is administered orally. It is metabolized in the liver to its active metabolite, delaprilat, which is responsible for most of the drug's ACE inhibition activity. The onset of action for delapril is within one hour of oral administration, with peak effects occurring in about four to six hours. The duration of action typically lasts for 24 hours, allowing for once or twice daily dosing. Delapril and its metabolites are primarily excreted through the kidneys.
+Delapril is administered orally and is absorbed through the gastrointestinal tract. It is a prodrug, meaning it is metabolized into its active form, delaprilat, in the liver. The drug is then excreted primarily through the kidneys.
-==Clinical Uses==
-Delapril is used in the management of:
-* [[Hypertension]] - to lower blood pressure and reduce the risk of cardiovascular events, such as heart attack and stroke.
-* [[Congestive Heart Failure]] - to improve symptoms, reduce hospitalization, and increase survival in patients with heart failure.
-==Side Effects==
-Common side effects of delapril include:
-* Cough
-* Dizziness
-* Headache
-* Fatigue
-* Nausea
-Serious side effects may include:
+==Clinical uses==
-* Angioedema
+Delapril is used to manage hypertension and may be prescribed alone or in combination with other antihypertensive agents. It is also used in the treatment of [[heart failure]] and to improve survival after a [[myocardial infarction]] (heart attack).
-* Hyperkalemia
-* Renal impairment
-Patients with a history of angioedema related to previous ACE inhibitor therapy should not take delapril. It is also contraindicated in pregnancy due to the risk of birth defects.
+==Side effects==
+Common side effects of Delapril include cough, dizziness, and fatigue. Like other ACE inhibitors, it can cause [[hyperkalemia]] (elevated potassium levels) and [[angioedema]] (swelling of the deeper layers of the skin). Patients are advised to report any signs of swelling or difficulty breathing to their healthcare provider immediately.
-==Drug Interactions==
+==Contraindications==
-Delapril can interact with several other medications, including:
+Delapril is contraindicated in patients with a history of [[angioedema]] related to previous ACE inhibitor therapy and in those with [[renal artery stenosis]]. It should not be used during pregnancy due to the risk of fetal harm.
-* [[Diuretics]] - may increase the risk of hypotension.
-* [[Potassium supplements]] and potassium-sparing diuretics - may increase the risk of hyperkalemia.
-* [[Nonsteroidal anti-inflammatory drugs (NSAIDs)]] - may reduce the antihypertensive effects of delapril.
-==Conclusion==
+==Related pages==
-Delapril is an effective medication for the management of hypertension and congestive heart failure. Its mechanism of action involves the inhibition of the angiotensin-converting enzyme, leading to vasodilation and decreased blood volume. While generally well-tolerated, it is important for patients to be aware of potential side effects and drug interactions.
+* [[Hypertension]]
+* [[ACE inhibitors]]
+* [[Heart failure]]
+* [[Myocardial infarction]]
 [[Category:ACE inhibitors]]
-[[Category:Antihypertensive drugs]]
+[[Category:Antihypertensive agents]]
-{{medicine-stub}}