Felypressin: Difference between revisions

Felypressin
	[[File:\|frameless\|220px\|alt=\|]]
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number	56-59-7
PubChem	161323
DrugBank	DB00092
ChemSpider	141451
KEGG	D04266

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Revision as of 17:34, 30 December 2024

Synthetic vasoconstrictor used in dentistry

Felypressin is a synthetic vasoconstrictor that is commonly used in dentistry as an adjunct to local anesthetics. It is a peptide analog of vasopressin, a naturally occurring hormone that regulates the body's retention of water and constricts blood vessels.

Mechanism of Action

Felypressin acts on vasopressin receptors in the vascular smooth muscle, leading to vasoconstriction. This action helps to prolong the effect of local anesthetics by reducing blood flow to the area, thereby decreasing the rate of anesthetic absorption into the bloodstream.

Uses

Felypressin is primarily used in dental procedures to enhance the efficacy of local anesthetics such as lidocaine. It is particularly useful in patients who may be sensitive to epinephrine, another vasoconstrictor commonly used in dental anesthetics.

Side Effects

While felypressin is generally well-tolerated, it can cause side effects such as hypertension, bradycardia, and arrhythmias. It is important to use it with caution in patients with cardiovascular disease.

Contraindications

Felypressin should not be used in patients with known hypersensitivity to the drug or in those with severe cardiovascular conditions. It is also contraindicated in pregnancy due to potential effects on uterine contraction.

References

External Links

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-== Felypressin‏‎ ==
-[[File:Felypressin_structure.png|thumb|Chemical structure of Felypressin]]
+{{Short description|Synthetic vasoconstrictor used in dentistry}}
+{{Infobox drug
+| name = Felypressin
+| image = <!-- Image removed -->
+| width =
+| alt =
+| caption =
+| pronounce =
+| tradename =
+| Drugs.com =
+| MedlinePlus =
+| licence_EU =
+| DailyMedID =
+| pregnancy_AU =
+| pregnancy_US =
+| pregnancy_category =
+| legal_AU =
+| legal_BR =
+| legal_CA =
+| legal_DE =
+| legal_NZ =
+| legal_UK =
+| legal_US =
+| legal_status =
+| routes_of_administration =
+| bioavailability =
+| protein_bound =
+| metabolism =
+| elimination_half-life =
+| excretion =
+| CAS_number = 56-59-7
+| ATC_prefix =
+| ATC_suffix =
+| ATC_supplemental =
+| PubChem = 161323
+| IUPHAR_ligand = 2168
+| DrugBank = DB00092
+| ChemSpiderID = 141451
+| UNII = 3F3U0Y960O
+| KEGG = D04266
+| ChEBI = 5000
+| ChEMBL = 1201588
+| synonyms =
+| IUPAC_name =
+| C=46
+| H=65
+| N=13
+| O=12
+| S=2
+| molecular_weight = 1080.22
+}}
-Felypressin is a synthetic non-catecholamine vasopressin analogue that is commonly used in dentistry and oral surgery as a vasoconstrictor. It is a derivative of vasopressin, also known as antidiuretic hormone (ADH), which plays a key role in regulating water balance in the body.
+'''Felypressin''' is a [[synthetic]] [[vasoconstrictor]] that is commonly used in [[dentistry]] as an adjunct to [[local anesthetics]]. It is a [[peptide]] analog of [[vasopressin]], a naturally occurring hormone that regulates the body's retention of water and constricts blood vessels.
-=== Pharmacology ===
+==Mechanism of Action==
+Felypressin acts on [[vasopressin receptors]] in the [[vascular smooth muscle]], leading to [[vasoconstriction]]. This action helps to prolong the effect of local anesthetics by reducing blood flow to the area, thereby decreasing the rate of anesthetic absorption into the bloodstream.
-Felypressin acts primarily on V1 receptors, leading to vasoconstriction of blood vessels. This results in increased blood pressure and reduced blood flow to the site of administration, making it an effective local hemostatic agent. It also has some vasopressin-like effects on V2 receptors, which can lead to antidiuretic effects.
+==Uses==
+Felypressin is primarily used in [[dental procedures]] to enhance the efficacy of local anesthetics such as [[lidocaine]]. It is particularly useful in patients who may be sensitive to [[epinephrine]], another vasoconstrictor commonly used in dental anesthetics.
-=== Clinical Uses ===
+==Side Effects==
+While felypressin is generally well-tolerated, it can cause side effects such as [[hypertension]], [[bradycardia]], and [[arrhythmias]]. It is important to use it with caution in patients with [[cardiovascular disease]].
-In dentistry, Felypressin is commonly used in local anesthesia solutions to prolong the anesthetic effect and reduce bleeding during procedures such as tooth extractions and periodontal surgery. Its vasoconstrictive properties help to minimize bleeding, which can improve visibility and facilitate the dental procedure.
+==Contraindications==
+Felypressin should not be used in patients with known hypersensitivity to the drug or in those with severe cardiovascular conditions. It is also contraindicated in [[pregnancy]] due to potential effects on uterine contraction.
-=== Side Effects ===
+==See Also==
+* [[Vasopressin]]
+* [[Local anesthetic]]
+* [[Vasoconstrictor]]
-Common side effects of Felypressin include transient hypertension, tachycardia, and local tissue necrosis if injected intravascularly. It is important for healthcare providers to use the appropriate concentration and dosage to minimize the risk of adverse effects.
+==References==
+{{Reflist}}
+==External Links==
+* [https://www.drugbank.ca/drugs/DB00092 DrugBank: Felypressin]
+* [https://pubchem.ncbi.nlm.nih.gov/compound/161323 PubChem: Felypressin]
+[[Category:Vasoconstrictors]]
+[[Category:Dental drugs]]
+[[Category:Peptides]]
 [[Category:Pharmacology]]
-[[Category:Dentistry]]
-{{medicine-stub}}