GATA5: Difference between revisions
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'''GATA5''' is a gene that | |||
{{Infobox gene | |||
| name = GATA5 | |||
| image = <!-- Image of the gene or related structure --> | |||
| caption = <!-- Caption for the image --> | |||
| HGNCid = 4170 | |||
| Symbol = GATA5 | |||
| AltSymbols = | |||
| EntrezGene = 140628 | |||
| OMIM = 611496 | |||
| RefSeq = NM_080473 | |||
| UniProt = Q9BWX5 | |||
| PDB = | |||
| ECnumber = | |||
| Chromosome = 20 | |||
| Arm = q | |||
| Band = 13 | |||
}} | |||
'''GATA5''' is a [[gene]] that encodes a member of the [[GATA transcription factor]] family. These transcription factors are characterized by their ability to bind to the [[GATA DNA sequence]] and regulate the expression of genes involved in [[cell differentiation]] and [[development]]. | |||
== Function == | == Function == | ||
GATA5 | GATA5 plays a crucial role in the development of various [[tissues]] and [[organs]], particularly in the [[cardiovascular system]]. It is involved in the regulation of [[cardiac muscle]] development and function. GATA5 is also implicated in the development of the [[endoderm]], which gives rise to the [[gastrointestinal tract]] and associated organs. | ||
== Clinical | == Clinical Significance == | ||
Mutations in the GATA5 gene have been associated with | Mutations in the GATA5 gene have been associated with several [[congenital heart defects]], including [[atrial septal defect]]s and [[ventricular septal defect]]s. Research suggests that GATA5 may also play a role in the development of certain [[cancers]], such as [[colorectal cancer]]. | ||
[[ | == Interactions == | ||
GATA5 interacts with other members of the GATA family, such as [[GATA4]] and [[GATA6]], to regulate gene expression. These interactions are important for the proper development of the heart and other organs. | |||
== | == See Also == | ||
* [[GATA transcription factors]] | |||
* [[Cardiac development]] | |||
* [[Congenital heart defects]] | |||
== | == References == | ||
<references/> | |||
== | == External Links == | ||
* [GATA5 at GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA5) | |||
* [GATA5 at NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/140628) | |||
[[Category:Genes]] | [[Category:Genes on human chromosome 20]] | ||
[[Category:Transcription factors]] | [[Category:Transcription factors]] | ||
[[Category: | [[Category:Developmental biology]] | ||
Latest revision as of 20:40, 30 December 2024
| Symbol | – |
|---|---|
| HGNC ID | 4170 |
| Alternative symbols | – |
| Entrez Gene | 140628 |
| OMIM | 611496 |
| RefSeq | NM_080473 |
| UniProt | Q9BWX5 |
| Chromosome | – |
| Locus supplementary data | – |
GATA5 is a gene that encodes a member of the GATA transcription factor family. These transcription factors are characterized by their ability to bind to the GATA DNA sequence and regulate the expression of genes involved in cell differentiation and development.
Function[edit]
GATA5 plays a crucial role in the development of various tissues and organs, particularly in the cardiovascular system. It is involved in the regulation of cardiac muscle development and function. GATA5 is also implicated in the development of the endoderm, which gives rise to the gastrointestinal tract and associated organs.
Clinical Significance[edit]
Mutations in the GATA5 gene have been associated with several congenital heart defects, including atrial septal defects and ventricular septal defects. Research suggests that GATA5 may also play a role in the development of certain cancers, such as colorectal cancer.
Interactions[edit]
GATA5 interacts with other members of the GATA family, such as GATA4 and GATA6, to regulate gene expression. These interactions are important for the proper development of the heart and other organs.
See Also[edit]
References[edit]
<references/>
External Links[edit]
- [GATA5 at GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA5)
- [GATA5 at NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/140628)
