Pyridinoline: Difference between revisions
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{{DISPLAYTITLE:Pyridinoline}} | |||
== | ==Pyridinoline== | ||
[[File:Pyridinoline.png|thumb|right|Chemical structure of pyridinoline]] | |||
'''Pyridinoline''' is a [[cross-linking]] compound found in [[collagen]] and [[elastin]] fibers, which are essential components of the [[extracellular matrix]] in [[connective tissue]]. It plays a crucial role in the stability and mechanical properties of these tissues. | |||
Pyridinoline is a | ==Structure and Function== | ||
Pyridinoline is a [[tricyclic]] compound that forms as a result of the enzymatic cross-linking of [[collagen]] molecules. It is derived from the [[amino acids]] [[lysine]] and [[hydroxylysine]], which are modified by the enzyme [[lysyl oxidase]]. This cross-linking process is essential for the maturation and stabilization of collagen fibers, providing tensile strength and structural integrity to tissues such as [[bone]], [[cartilage]], and [[tendons]]. | |||
== | ==Biological Significance== | ||
Pyridinoline is predominantly found in [[type I collagen]], which is the most abundant form of collagen in the human body. It is also present in [[type II collagen]], which is primarily found in [[cartilage]]. The presence of pyridinoline cross-links is indicative of mature and stable collagen fibers, and its levels can be used as a biomarker for bone and cartilage turnover. | |||
==Clinical Relevance== | |||
Elevated levels of pyridinoline in [[urine]] or [[blood]] can be indicative of increased bone resorption, which is a characteristic of conditions such as [[osteoporosis]] and [[rheumatoid arthritis]]. Monitoring pyridinoline levels can help in the assessment of these conditions and the effectiveness of therapeutic interventions. | |||
==Related pages== | |||
* [[Collagen]] | * [[Collagen]] | ||
* [[Elastin]] | * [[Elastin]] | ||
* [[Connective tissue]] | |||
* [[Lysyl oxidase]] | |||
* [[Osteoporosis]] | * [[Osteoporosis]] | ||
[[Category:Biochemistry]] | [[Category:Biochemistry]] | ||
[[Category: | [[Category:Connective tissue]] | ||
Latest revision as of 10:46, 15 February 2025
Pyridinoline[edit]
Pyridinoline is a cross-linking compound found in collagen and elastin fibers, which are essential components of the extracellular matrix in connective tissue. It plays a crucial role in the stability and mechanical properties of these tissues.
Structure and Function[edit]
Pyridinoline is a tricyclic compound that forms as a result of the enzymatic cross-linking of collagen molecules. It is derived from the amino acids lysine and hydroxylysine, which are modified by the enzyme lysyl oxidase. This cross-linking process is essential for the maturation and stabilization of collagen fibers, providing tensile strength and structural integrity to tissues such as bone, cartilage, and tendons.
Biological Significance[edit]
Pyridinoline is predominantly found in type I collagen, which is the most abundant form of collagen in the human body. It is also present in type II collagen, which is primarily found in cartilage. The presence of pyridinoline cross-links is indicative of mature and stable collagen fibers, and its levels can be used as a biomarker for bone and cartilage turnover.
Clinical Relevance[edit]
Elevated levels of pyridinoline in urine or blood can be indicative of increased bone resorption, which is a characteristic of conditions such as osteoporosis and rheumatoid arthritis. Monitoring pyridinoline levels can help in the assessment of these conditions and the effectiveness of therapeutic interventions.
