Platelet factor 4: Difference between revisions
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== | {{Infobox protein | ||
PF4 | | name = Platelet factor 4 | ||
| image = <!-- Image removed --> | |||
| caption = <!-- Caption removed --> | |||
| symbol = PF4 | |||
| gene = PF4 | |||
| organism = Homo sapiens | |||
}} | |||
'''Platelet factor 4''' ('''PF4''') is a small cytokine belonging to the [[chemokine]] family that is released from the [[alpha granules]] of activated [[platelets]] during [[platelet aggregation]]. | |||
PF4 is released from the alpha | |||
== | == Function == | ||
PF4 is | PF4 is known to play a role in [[coagulation]] and [[inflammation]]. It binds to [[heparin]], neutralizing its anticoagulant effect, and is involved in the regulation of [[thrombosis]]. PF4 also has a role in [[wound healing]] and [[angiogenesis]]. | ||
==See also== | == Clinical significance == | ||
PF4 is implicated in [[heparin-induced thrombocytopenia]] (HIT), a condition where antibodies form against the PF4-heparin complex, leading to a pro-thrombotic state. It is also being studied for its potential role in [[cancer]] and [[atherosclerosis]]. | |||
== Structure == | |||
PF4 is a member of the [[CXC chemokine]] family and is encoded by the [[PF4 gene]] located on [[chromosome 4]] in humans. It is a tetrameric protein with a molecular weight of approximately 7.8 kDa. | |||
== Interactions == | |||
PF4 interacts with various [[cell surface receptors]] and [[proteins]], influencing [[cell signaling]] pathways involved in [[immune response]] and [[cell migration]]. | |||
== See also == | |||
* [[Chemokine]] | * [[Chemokine]] | ||
* [[ | * [[Platelet]] | ||
* [[Heparin-induced thrombocytopenia]] | * [[Heparin-induced thrombocytopenia]] | ||
==References== | == References == | ||
{{Reflist}} | |||
== External links == | |||
* [https://www.wikimd.com/wiki/Platelet_factor_4 Platelet factor 4 on WikiMD] | |||
[[Category:Proteins]] | |||
[[Category:Coagulation system]] | |||
[[Category:Human proteins]] | |||
[[Category:Chemokines]] | [[Category:Chemokines]] | ||
Latest revision as of 16:56, 29 December 2024
Platelet factor 4 (PF4) is a small cytokine belonging to the chemokine family that is released from the alpha granules of activated platelets during platelet aggregation.
Function[edit]
PF4 is known to play a role in coagulation and inflammation. It binds to heparin, neutralizing its anticoagulant effect, and is involved in the regulation of thrombosis. PF4 also has a role in wound healing and angiogenesis.
Clinical significance[edit]
PF4 is implicated in heparin-induced thrombocytopenia (HIT), a condition where antibodies form against the PF4-heparin complex, leading to a pro-thrombotic state. It is also being studied for its potential role in cancer and atherosclerosis.
Structure[edit]
PF4 is a member of the CXC chemokine family and is encoded by the PF4 gene located on chromosome 4 in humans. It is a tetrameric protein with a molecular weight of approximately 7.8 kDa.
Interactions[edit]
PF4 interacts with various cell surface receptors and proteins, influencing cell signaling pathways involved in immune response and cell migration.
See also[edit]
References[edit]
<references group="" responsive="1"></references>
