Cephamycin: Difference between revisions
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{{DISPLAYTITLE:Cephamycin}} | |||
== | == Cephamycin == | ||
[[File:Cephamycin_core_structure.svg|thumb|right|Core structure of cephamycin]] | |||
Cephamycins are a group of [[beta-lactam antibiotics]] that are structurally and functionally related to [[cephalosporins]]. They are characterized by the presence of a methoxy group at the 7-alpha position of the beta-lactam ring, which confers resistance to certain beta-lactamases produced by [[bacteria]]. This makes cephamycins particularly useful in treating infections caused by beta-lactamase-producing organisms. | |||
== Structure and Mechanism of Action == | |||
Cephamycins share a core structure with cephalosporins, which includes a beta-lactam ring fused to a dihydrothiazine ring. The distinguishing feature of cephamycins is the methoxy group at the 7-alpha position. This structural modification enhances their stability against beta-lactamase enzymes. | |||
The mechanism of action of cephamycins, like other beta-lactam antibiotics, involves the inhibition of bacterial [[cell wall]] synthesis. They achieve this by binding to and inactivating penicillin-binding proteins (PBPs), which are essential for the cross-linking of the peptidoglycan layer of the bacterial cell wall. This leads to cell lysis and death of the bacterium. | |||
== | == Clinical Uses == | ||
Cephamycins | Cephamycins are used to treat a variety of bacterial infections, particularly those caused by anaerobic bacteria and Gram-negative organisms. They are effective against organisms such as [[Escherichia coli]], [[Klebsiella pneumoniae]], and [[Bacteroides fragilis]]. | ||
Commonly used cephamycins include: | |||
* [[Cefoxitin]] | |||
* [[Cefotetan]] | |||
These antibiotics are often used in surgical prophylaxis and in the treatment of intra-abdominal and pelvic infections. | |||
== Resistance == | |||
While cephamycins are resistant to many beta-lactamases, resistance can still occur through other mechanisms. Bacteria may acquire resistance through the production of extended-spectrum beta-lactamases (ESBLs) or through alterations in penicillin-binding proteins. Additionally, efflux pumps and changes in porin channels can contribute to resistance. | |||
== Related Pages == | |||
== | |||
* [[Beta-lactam antibiotic]] | * [[Beta-lactam antibiotic]] | ||
* [[Cephalosporin]] | * [[Cephalosporin]] | ||
* [[ | * [[Antibiotic resistance]] | ||
[[Category: | [[Category:Beta-lactam antibiotics]] | ||
[[Category:Cephalosporins]] | [[Category:Cephalosporins]] | ||
Latest revision as of 11:26, 15 February 2025
Cephamycin[edit]
Cephamycins are a group of beta-lactam antibiotics that are structurally and functionally related to cephalosporins. They are characterized by the presence of a methoxy group at the 7-alpha position of the beta-lactam ring, which confers resistance to certain beta-lactamases produced by bacteria. This makes cephamycins particularly useful in treating infections caused by beta-lactamase-producing organisms.
Structure and Mechanism of Action[edit]
Cephamycins share a core structure with cephalosporins, which includes a beta-lactam ring fused to a dihydrothiazine ring. The distinguishing feature of cephamycins is the methoxy group at the 7-alpha position. This structural modification enhances their stability against beta-lactamase enzymes.
The mechanism of action of cephamycins, like other beta-lactam antibiotics, involves the inhibition of bacterial cell wall synthesis. They achieve this by binding to and inactivating penicillin-binding proteins (PBPs), which are essential for the cross-linking of the peptidoglycan layer of the bacterial cell wall. This leads to cell lysis and death of the bacterium.
Clinical Uses[edit]
Cephamycins are used to treat a variety of bacterial infections, particularly those caused by anaerobic bacteria and Gram-negative organisms. They are effective against organisms such as Escherichia coli, Klebsiella pneumoniae, and Bacteroides fragilis.
Commonly used cephamycins include:
These antibiotics are often used in surgical prophylaxis and in the treatment of intra-abdominal and pelvic infections.
Resistance[edit]
While cephamycins are resistant to many beta-lactamases, resistance can still occur through other mechanisms. Bacteria may acquire resistance through the production of extended-spectrum beta-lactamases (ESBLs) or through alterations in penicillin-binding proteins. Additionally, efflux pumps and changes in porin channels can contribute to resistance.
